FB2024_03 , released June 25, 2024
Allele: Dmel\Su(z)121
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General Information
Symbol
Dmel\Su(z)121
Species
D. melanogaster
Name
FlyBase ID
FBal0063038
Feature type
allele
Associated gene
Dmel\Su(z)12
Associated Insertion(s)
P{}Su(z)121
Carried in Construct
Key Links
Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Birve and Rasmuson-Lestander, 1994)
Mutagen
P-element activity
(Birve and Rasmuson-Lestander, 1994)
Progenitor genotype
Associated Insertion(s)
P{}Su(z)121
Cytology
Description

P-element insertion into codon 564 of the open reading frame.

(Birve et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      dendrite & dendritic arborising neuron | somatic clone

      (Parrish et al., 2007)

      egg | germline clone

      (Birve et al., 2001)

      neuroblast | somatic clone

      (Bello et al., 2007)
      Detailed Description
      Statement
      Reference

      Homozygous neuroblast clones in the third larval instar central brain and ventral ganglion are dramatically reduced in size compared to control clones and show a dramatic reduction in mitotic activity.

      (Bello et al., 2007)

      Single cell class IV dendrite arborisation (da) neuron clones that are homozygous for Su(z)121 show dendritic defects.

      (Parrish et al., 2007)

      Eggs derived from females carrying homozygous germ-line clones are highly abnormal.

      (Birve et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The repression of wis and wzm by z1 is suppressed by Su(z)121. The transformation seen in Asxunspecified, Scmunspecified, Pcunspecified and Pclunspecified heterozygotes is dominantly enhanced by Su(z)121, giving additional sex comb teeth on the second and third legs in male double heterozygous flies.

      (Birve and Rasmuson-Lestander, 1994)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P-element can revert the lethal phenotype.

      (Birve et al., 2001)

      Isolated in a screen for mutations that modify the repression of w alleles by z1.

      (Birve and Rasmuson-Lestander, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Su(z)12
      (Birve and Rasmuson-Lestander, 1994)
      Su(z)121
      (Vasanthi et al., 2013, Bello et al., 2007, Parrish et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)