FB2024_03 , released June 25, 2024
Allele: Dmel\wgunspecified
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General Information
Symbol
Dmel\wgunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0055798
Feature type
allele
Associated gene
Dmel\wg
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        wgunspecified embryos lack smooth cuticle.

        (Peterson-Nedry et al., 2008)

        Mutant embryos have a "lawn of denticles" phenotype.

        (Thompson et al., 2002)

        NB4-2 is present in 18% of hemisegments in mutant embryos.

        (Bhat et al., 2000)

        wg mutant embryos differentiate row 5 denticles, alternating in mirror image with small, row 2 - 4 type denticles.

        (Gritzan et al., 1999)

        Mutant embryos show an increase in the number of midline glial cells. Commissures are reduced.

        (Hummel et al., 1999)

        The developing stomatogastric nervous system is fused to one invagination (instead of the normal three) in mutant embryos.

        (The et al., 1999)

        Homozygous embryos have a broad array of central nervous system defects, including gaps in the longitudinals and poorly formed commissures.

        (Loureiro and Peifer, 1998)

        The anteriormost part of the protocerebrum is absent from stage 13 onwards in homozygous embryos. The posterior part of the protocerebrum appears normal in homozygous embryos, and the deutocerebrum and tritocerebrum differentiate normally. All major brain commissures and descending pathways are present. The frontal connective innervates the brain more posteriorly than in wild-type flies.

        (Richter et al., 1998)

        Only one invagination in the dorsal epithelium of the foregut (which will give rise to the stomatogastric nervous system) forms in wgunspecified embryos, in contrast to wild-type, where three invaginations are formed.

        (Hacker et al., 1997)

        Denticle bands are duplicated at the expense of naked cuticle in wgunspecified mutant embryos.

        (Tearle and Nusslein-Volhard, 1987)

        The notum may be reduced, deleted or duplicated. The pleura may be reduced. Mutant mesothoracic discs are smaller than normal and show increased cell death.

        (Sharma and Shekaran, 1983)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        wg[+]/wgunspecified is an enhancer of visible phenotype of Scer\GAL4sd-SG29.1, groNterm.UAS

        (Lawrence et al., 2000)
        Phenotype Manifest In
        Enhancer of
        NOT Enhancer of
        Statement
        Reference

        wgunspecified is a non-enhancer of interneuron phenotype of Scer\GAL4eg-Mz360, drlUAS.cCa

        (Yoshikawa et al., 2003)
        Suppressor of
        NOT Suppressor of
        Statement
        Reference

        wgunspecified is a non-suppressor of interneuron phenotype of Scer\GAL4eg-Mz360, drlUAS.cCa

        (Yoshikawa et al., 2003)

        wgunspecified is a non-suppressor of phenotype of arm3

        (Cox et al., 2000)
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The addition of wgunspecified has no effect on the interneuron phenotype seen in drlScer\UAS.cCa, Scer\GAL4eg-Mz360 animals.

        (Yoshikawa et al., 2003)

        wgunspecified/+ enhances the wing defects caused by expression of groNterm.Scer\UAS under the control of Scer\GAL4sd-SG29.1.

        (Lawrence et al., 2000)

        Embryos null for both wg and en have no smooth cuticle, and the remaining denticles are row 5 like.

        (Gritzan et al., 1999)

        The segment polarity phenotype seen in embryos derived from dally06464 germline clones is enhanced in combination with wgunspecified. Penetrance is increased from 8% to 16%.

        (Lin and Perrimon, 1999)

        Dominantly enhances the penetrance of the RP2/sib lineage phenotype produced by fz2ECD.GPI.Scer\UAS.T:Hsap\MYC expressed under the control of Scer\GAL4da.G32.

        (Bhat, 1998)

        The production of extra eve-positive mesodermal cells caused by expression of Ras85DG13Q.Scer\UAS under the control of Scer\GAL4unspecified is suppressed if the embryos are also carrying wgunspecified. No eve-positive mesodermal cells develop in wgunspecified; Dlunspecified double mutants, as in wgunspecified single mutants.

        (Carmena et al., 1998)

        When discs expressing Dl::NΔECN.Scer\UAS under the control of Scer\GAL4C96 are also mutant for wg, no ZNC forms at all.

        (Johnston and Edgar, 1998)

        If dshw,dshunspecified flies are also made heterozygous for a wg allele, the frequency of wg-like defects increases to 100%, including missing/reduced wings, duplicated nota, head defects and leg abnormalities.

        (Theisen et al., 1994)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        unspecified
        (Sharma and Shekaran, 1983)
        wgunspecified
        Name Synonyms
        winglessnull
        (Peterson-Nedry et al., 2008)
        Secondary FlyBase IDs
          References (22)