FB2024_03 , released June 25, 2024
Allele: Dmel\dshw
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General Information
Symbol
Dmel\dshw
Species
D. melanogaster
Name
FlyBase ID
FBal0034440
Feature type
allele
Associated gene
Dmel\dsh
Associated Insertion(s)
Carried in Construct
P{dsh.w}
Key Links
Transgenic product class
genomic_DNA
(Theisen et al., 1994)
wild_type
(Theisen et al., 1994)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Theisen et al., 1994)
wild_type
(Theisen et al., 1994)
Mutagen
in vitro construct
(Theisen et al., 1994)
Progenitor genotype
Carried in construct
P{dsh.w}
Cytology
Description

EcoRI-BglII fragment including dsh transcription unit, 184bp of 5' flanking and 240bp flanking DNA.

(Theisen et al., 1994)
Allele components
Component
Use(s)
Regulatory region(s)
dsh
Encoded product / tool
dsh
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      5% of dsh4/Y flies carrying one copy of dshw have defects in adult structures. The defects consist primarily of deleted or duplicated antennae and/or deleted wings with a concurrent duplication of notal structures.

      (Haerry et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      dsh4, dshw has visible phenotype, enhanceable by wg[+]/wgen11

      (Haerry et al., 1997)

      dsh4, dshw has visible phenotype, enhanceable by sgl[+]/sglSG9

      (Haerry et al., 1997)

      dsh4, dshw has visible phenotype, enhanceable by sgl[+]/sgl08310

      (Haerry et al., 1997)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      dsh4, dshw has adult phenotype, enhanceable by wg[+]/wgen11

      (Haerry et al., 1997)

      dsh4, dshw has adult phenotype, enhanceable by sgl[+]/sglSG9

      (Haerry et al., 1997)

      dsh4, dshw has adult phenotype, enhanceable by sgl[+]/sgl08310

      (Haerry et al., 1997)

      dshunspecified, dshw has wing phenotype, enhanceable by wgunspecified

      (Theisen et al., 1994)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The dsh4 phenotype is dominantly enhanced by wgen11, sglSG9 and sgl08310; dsh4/Y flies that are also heterozygous for wgen11, sglSG9 or sgl08310 show defects in adult structures in 62%, 19% and 41% of cases respectively.

      (Haerry et al., 1997)

      If dshw,dshunspecified flies are also made heterozygous for a wg allele, the frequency of wg-like defects increases to 100%, including missing/reduced wings, duplicated nota, head defects and leg abnormalities.

      (Theisen et al., 1994)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      dshw partially rescues dsh1

      (Theisen et al., 1994)

      dshw partially rescues dshunspecified

      (Theisen et al., 1994)
      Comments

      Partly rescues the polarity defects of dsh1 and partially rescues the lethality of lethal dsh alleles. Flies carrying lethal alleles of dsh and dshw survive to adulthood but exhibit cell polarity defects. 8% have missing wings and duplicated nota as seen in wg mutants.

      (Theisen et al., 1994)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dshw
      Name Synonyms
      Secondary FlyBase IDs
        References (2)