FB2024_03 , released June 25, 2024
Allele: Dmel\fzGL31
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General Information
Symbol
Dmel\fzGL31
Species
D. melanogaster
Name
FlyBase ID
FBal0049585
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Amino acid replacement: P429L. Amino acid replacement: V454F.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

C14366820T

Amino acid change:

P429L | fz-PA; P429L | fz-PC

Reported amino acid change:

P429L

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. One of two amino acid substitutions in mutant.

Nucleotide change:

G14366894T

Amino acid change:

V454F | fz-PA; V454F | fz-PC

Reported amino acid change:

V454F

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. One of two amino acid substitutions in mutant.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Wing margin bristles made by fzGL31 mutant clones are abnormally rotated away from the margin.

fzGL31 has a moderate multiple wing hair phenotype in combination with fz30.

Non-autonomous phenotype in wing clones.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Embryos derived from fzGL31, fz2e2 female germline clones that are also zygotically mutant for fzGL31 and fz2e2 exhibit defects in the specification of naked cuticle. Expression of one copy of the fzαTub84B.PP transgene restores normal patterning to the cuticle of fzGL31; fz2e2 embryos from germline clones and allows 11% of these mutants to eclose. In fz57.αTub84B, fz81.αTub84B and fzΔCRD1.αTub84B rescue crosses, denticles are present in regions that should be entirely naked and some denticle belts are fused; these transgenes are incapable of restoring viability to fzGL31, fz2e2 embryos. fzGL31, fz2e2 clones in the wing often fail to generate bristles. Expression of fzαTub84B.PP in fzGL31, fz2e2 clones in the wing fully restores bristle patterning. fzGL31, fz2e2 clones in the wing are partially rescued by expression of fz57.αTub84B, but still show subtle defects in the spacing of the margin bristles. Clones rescued by fz81.αTub84B show more severe bristle spacing problems. Clones rescued by fzΔCRD1.αTub84B have ectopic margin bristles, but these appear to be derived from neighbouring cells as the bristles are dark, while the clones lack y. Clones rescued by fzWIFCRD.αTub84B still show observable defects in the patterning of the margin, with some places where a bristle socket has formed in the place of an apparently missing bristle.

Embryos that lack zygotic fz and fz2 function which are derived from fzGL31/fzGL31 fz2e2 females mated to fzGL31 fz2e2/+ males are dramatically shortened and lack naked cuticle.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
fzGL31
Name Synonyms
Secondary FlyBase IDs
    References (3)