FlyBase Allele Report: Dmel\w[Adh.PB]

General Information

Symbol

Dmel\w^Adh.PB

Species

D. melanogaster

Name

Alcohol dehydrogenase promoter construct of Birchler

FlyBase ID

FBal0033127

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

Carried in Construct

P{Adh-w.B}

Also Known As

Adh-w#2

Key Links

Transgenic product class

Mutagen

Nature of the Allele

Transgenic product class

Mutagen

P-element activity

(Birchler, 1992)

in vitro construct

(Bhadra et al., 1997, Pal-Bhadra et al., 1995, Birchler et al., 1990)

Progenitor genotype

Carried in construct

P{Adh-w.B}

Cytology

Description

1.8kb promoter region of Adh drives expression of a 6.5kb w structural gene.

(Pal-Bhadra et al., 1999)

Adh promoter region, including distal and proximal promoters, fused to the w coding region.

(Birchler et al., 1990)

Allele components

Component

Use(s)

Regulatory region(s)

Adh

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

pigment cell

(Hiebert and Birchler, 1994)

Detailed Description

Statement

Reference

Eye colour: intermediate between wild type and w¹. w^Adh.PB males that are also mutant for mle⁴ show paler eye pigmentation with respect their mle⁴/+ sibs.

(Hiebert and Birchler, 1994)

Homozygous males are darker than homozygous females. Triple X metafemale individuals homozygous for w^Adh.PB exhibit a lighter eye colour than w^Adh.PB homozygous XX females.

(Birchler, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

w^Adh.PB has abnormal eye color | recessive phenotype, suppressible by Low¹

(Bhadra et al., 1997)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

w^Adh.PB has phenotype, non-enhanceable by ox¹

(Frolov et al., 2000)

w^Adh.PB has phenotype, non-enhanceable by Wow^γb

(Birchler et al., 1994)

w^Adh.PB has phenotype, non-enhanceable by Wow^γe

(Birchler et al., 1994)

w^Adh.PB has phenotype, non-enhanceable by Wow^ems1

(Birchler et al., 1994)

w^Adh.PB has phenotype, non-enhanceable by Wow^hd1

(Birchler et al., 1994)

w^Adh.PB has phenotype, non-enhanceable by In(3)Msu¹

(Csink et al., 1994)

w^Adh.PB has phenotype, non-enhanceable by In(3)Msu²

(Csink et al., 1994)

w^Adh.PB has phenotype, non-enhanceable by Rm62^F

(Csink et al., 1994)

w^Adh.PB has phenotype, non-enhanceable by Rm62^H

(Csink et al., 1994)

w^Adh.PB has phenotype, non-enhanceable by Rm62^K

(Csink et al., 1994)

w^Adh.PB has phenotype, non-enhanceable by Rm62^D

(Csink et al., 1994)

w^Adh.PB has phenotype, non-enhanceable by Rm62^Dem

(Csink et al., 1994)

w^Adh.PB has phenotype, non-enhanceable by Rm62^E

(Csink et al., 1994)

Suppressed by

Statement

Reference

w^Adh.PB has pigment cell phenotype, suppressible by Low¹

(Bhadra et al., 1997)

NOT suppressed by

Statement

Reference

w^Adh.PB has phenotype, non-suppressible by ox¹

(Frolov et al., 2000)

w^Adh.PB has phenotype, non-suppressible by Wow^γb

(Birchler et al., 1994)

w^Adh.PB has phenotype, non-suppressible by Wow^γe

(Birchler et al., 1994)

w^Adh.PB has phenotype, non-suppressible by Wow^ems1

(Birchler et al., 1994)

w^Adh.PB has phenotype, non-suppressible by Wow^hd1

(Birchler et al., 1994)

w^Adh.PB has phenotype, non-suppressible by In(3)Msu¹

(Csink et al., 1994)

w^Adh.PB has phenotype, non-suppressible by In(3)Msu²

(Csink et al., 1994)

w^Adh.PB has phenotype, non-suppressible by Rm62^F

(Csink et al., 1994)

w^Adh.PB has phenotype, non-suppressible by Rm62^H

(Csink et al., 1994)

w^Adh.PB has phenotype, non-suppressible by Rm62^K

(Csink et al., 1994)

w^Adh.PB has phenotype, non-suppressible by Rm62^D

(Csink et al., 1994)

w^Adh.PB has phenotype, non-suppressible by Rm62^Dem

(Csink et al., 1994)

w^Adh.PB has phenotype, non-suppressible by Rm62^E

(Csink et al., 1994)

Other

Statement

Reference

Adh^w.PR, w^Adh.PB has pigment cell phenotype

(Pal-Bhadra et al., 1999)

Adh^D-5000, w^Adh.PB has pigment cell phenotype

(Pal-Bhadra et al., 1999)

Adh^D+53:+328, w^Adh.PB has pigment cell phenotype

(Pal-Bhadra et al., 1999)

Adh^hs.PC, w^Adh.PB has pigment cell phenotype

(Pal-Bhadra et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The eye colour of flies carrying w^Adh.PB on either the X or 3rd chromosome is darkened by a single copy of Low¹.

(Bhadra et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Adh-w#2

(Benevolenskaya et al., 1998, Frolov and Birchler, 1998, Birchler et al., 1994)

w^Adh.PB

Name Synonyms

Alcohol dehydrogenase promoter construct of Birchler

Secondary FlyBase IDs

References (13)

Report Sections

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