FlyBase Allele Report: Dmel\ox[1]

General Information

Symbol

Dmel\ox¹

Species

D. melanogaster

Name

FlyBase ID

FBal0028464

Feature type

allele

Associated gene

Dmel\ox

Associated Insertion(s)

P{PZ}ox¹

Carried in Construct

Also Known As

ms(2)00815

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Frolov et al., 2001, Frolov et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999, Castrillon et al., 1993)

Progenitor genotype

Associated Insertion(s)

P{PZ}ox¹

Cytology

Description

P{PZ} insertion 15bp upstream of the 5' end of ox.

(Frolov et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:12,757,512..12,757,519 [-]

(Frolov et al., 2001, Frolov et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999, Castrillon et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

male sterile

male sterile (with Df(2R)12-1)

(Frolov et al., 2000)

male sterile (with Df(2R)38-1)

(Frolov et al., 2000)

male sterile (with Df(2R)44-2)

(Frolov et al., 2000)

male sterile (with Df(2R)68-1)

(Frolov et al., 2000)

male sterile (with Df(2R)86-1)

(Frolov et al., 2000)

male sterile (with Df(2R)107-2)

(Frolov et al., 2000)

male sterile (with Df(2R)157-1)

(Frolov et al., 2000)

male sterile | recessive

(Frolov et al., 2000, Spradling et al., 1999)

partially lethal - majority die | recessive

(Frolov et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

Approximately 10% of homozygotes survive to the adult stage.

(Frolov et al., 2000)

sterile when heterozygous with Df(2R)vg135.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

ox[+]/ox¹ is a suppressor of abnormal eye color phenotype of w^crr

(Frolov et al., 2000)

ox[+]/ox¹ is a suppressor of abnormal eye color phenotype of w^a

(Frolov et al., 2000)

ox[+]/ox¹ is a suppressor of abnormal eye color phenotype of w^cf

(Frolov et al., 2000)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

ox¹ is a non-enhancer of phenotype of w^Adh.PB

(Frolov et al., 2000)

NOT Suppressor of

Statement

Reference

ox¹ is a non-suppressor of phenotype of w^Adh.PB

(Frolov et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Eye colour: ox¹ dominantly suppresses the w^a eye colour phenotype; w^a flies have darker eyes if they are also carrying ox¹.

(Frolov et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ox¹ is rescued by ox^hs.PF

(Frolov et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

11754

cn¹ P{PZ}ox¹ Dgkε^ox-1/CyO; ry⁵⁰⁶

Kyoto

101942

cn¹ P{PZ}ox¹ / CyO ; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Comments

Precise excision of the P{PZ} insertion reverts the interaction with w^a.

(Frolov et al., 2000)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AF017783

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

ms(2)00815

(Frolov et al., 2001, Frolov et al., 2000, Spradling et al., 1999)

ms(2)00815⁰⁰⁸¹⁵

ox⁰⁰⁸¹⁵

ox¹

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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