FlyBase Allele Report: Dmel\w[cf]

General Information

Symbol

Dmel\w^cf

Species

D. melanogaster

Name

coffee

FlyBase ID

FBal0018222

Feature type

allele

Associated gene

Dmel\w

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Zachar and Bingham, 1982)

Progenitor genotype

Cytology

Description

Amino acid replacement: L49R. Amino acid replacement: G589E. Mutation near the amino terminus, and at the C-terminal end of putative transmembrane spanning α-helix 5.

(Mackenzie et al., 1999)

Point mutation.

(Bhadra et al., 1997, Bhadra and Birchler, 1996, Csink et al., 1994, Birchler and Hiebert, 1989, Rabinow and Birchler, 1989)

Point mutation in the structural portion of w.

(Rabinow et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Frolov et al., 2000, Mackenzie et al., 1999, Bhadra et al., 1997)

abnormal eye color | recessive

(Frolov et al., 1998)

decreased rate of copulation

(Xiao et al., 2017)

visible | recessive

Phenotype Manifest In

Malpighian tubule

pigment cell

(Mackenzie et al., 1999, Benevolenskaya et al., 1998, Frolov et al., 1998, Zachar and Bingham, 1982)

Detailed Description

Statement

Reference

Drosopterin (red pigment) levels are 29% of wild-type levels, xanthommatin levels (brown pigments) are 64% of wild-type levels.

(Mackenzie et al., 1999)

Increase in wild type eye pigment in the presence of Mow^gamma.

(Bhadra and Birchler, 1996)

Phenotype is not affected by Doa mutations.

(Rabinow and Birchler, 1989)

Eye colour: reddish brown.

(Zachar and Bingham, 1982)

Eye colour: deep ruby, later sepia-like. Eye colour: like w^cf when heterozygous with w¹. Eye colour: like w^cf when heterozygous with w^a. Eye colour: like w^cf when heterozygous with w^bl. Eye colour: like w^cf when heterozygous with w^co. Eye colour: like w^cf when heterozygous with w^col. Eye colour: like w^cf when heterozygous with w^sat. Malpighian tubule colour: bright yellow.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

w^cf has abnormal eye color phenotype, suppressible by ox[+]/ox¹

(Frolov et al., 2000)

w^cf has abnormal eye color | recessive phenotype, suppressible by Rga[+]/Rga⁰³⁸³⁴

(Frolov et al., 1998)

w^cf has abnormal eye color | recessive phenotype, suppressible by Low¹

(Bhadra et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

w^cf has phenotype, enhanceable by Ufo¹

(Bhadra et al., 1997)

w^cf has phenotype, enhanceable by Wow^γb

(Birchler et al., 1994)

w^cf has phenotype, enhanceable by Wow^γe

(Birchler et al., 1994)

w^cf has phenotype, enhanceable by Wow^ems1

(Birchler et al., 1994)

w^cf has phenotype, enhanceable by Wow^hd1

(Birchler et al., 1994)

NOT Enhanced by

Statement

Reference

w^cf has phenotype, non-enhanceable by In(3)Msu¹

(Csink et al., 1994)

w^cf has phenotype, non-enhanceable by In(3)Msu²

(Csink et al., 1994)

w^cf has phenotype, non-enhanceable by Rm62^D

(Csink et al., 1994)

w^cf has phenotype, non-enhanceable by Rm62^Dem

(Csink et al., 1994)

w^cf has phenotype, non-enhanceable by Rm62^E

(Csink et al., 1994)

w^cf has phenotype, non-enhanceable by Rm62^F

(Csink et al., 1994)

w^cf has phenotype, non-enhanceable by Rm62^H

(Csink et al., 1994)

w^cf has phenotype, non-enhanceable by Rm62^K

(Csink et al., 1994)

w^cf has phenotype, non-enhanceable by E(w^a)¹

(Birchler and Hiebert, 1989)

Suppressed by

Statement

Reference

w^cf has pigment cell phenotype, suppressible by RpLP0⁰¹⁵⁴⁴

(Frolov and Birchler, 1998)

w^cf has pigment cell phenotype, suppressible by Rga[+]/Rga⁰³⁸³⁴

(Frolov et al., 1998)

w^cf has pigment cell phenotype, suppressible by Low¹

(Bhadra et al., 1997)

w^cf has phenotype, suppressible by Pcf11^γb

(Rabinow et al., 1991)

w^cf has phenotype, suppressible by Pcf11^γc

(Rabinow et al., 1991)

w^cf has phenotype, suppressible by Pcf11^γd

(Rabinow et al., 1991)

w^cf has phenotype, suppressible by Pcf11^EMS3

(Rabinow et al., 1991)

w^cf has phenotype, suppressible by Pcf11^EMS4

(Rabinow et al., 1991)

w^cf has phenotype, suppressible by Pcf11^EMS5

(Rabinow et al., 1991)

w^cf has phenotype, suppressible by Pcf11^hd1

(Rabinow et al., 1991)

NOT suppressed by

Statement

Reference

w^cf has phenotype, non-suppressible by In(3)Msu¹

(Csink et al., 1994)

w^cf has phenotype, non-suppressible by In(3)Msu²

(Csink et al., 1994)

w^cf has phenotype, non-suppressible by Rm62^D

(Csink et al., 1994)

w^cf has phenotype, non-suppressible by Rm62^Dem

(Csink et al., 1994)

w^cf has phenotype, non-suppressible by Rm62^E

(Csink et al., 1994)

w^cf has phenotype, non-suppressible by Rm62^F

(Csink et al., 1994)

w^cf has phenotype, non-suppressible by Rm62^H

(Csink et al., 1994)

w^cf has phenotype, non-suppressible by Rm62^K

(Csink et al., 1994)

Other

Statement

Reference

sgl⁰⁵⁰⁰⁷, w^cf has pigment cell phenotype

(Benevolenskaya et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The eye colour of w^cf flies is darkened by a single copy of Low¹.

(Bhadra et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (2)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (1)

Bloomington

4450

w^cf

Notes on Origin

Discoverer

Nicoletti, 1960.

Comments

Located near w^Bwx and just distal to w^a.

(Welshons and Nicoletti, 1963)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

w^cf

(Xiao et al., 2017)

Name Synonyms

coffee

Secondary FlyBase IDs

References (18)

Report Sections

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