FlyBase Allele Report: Dmel\sno[71e3]

General Information

Symbol

Dmel\sno^71e3

Species

D. melanogaster

Name

FlyBase ID

FBal0032749

Feature type

allele

Associated gene

Dmel\sno

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Coyle-Thompson and Banerjee, 1993)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive | heat sensitive

(Coyle-Thompson and Banerjee, 1993)

visible

(Thumm and Kadowaki, 2001)

visible | recessive | heat sensitive

(Coyle-Thompson and Banerjee, 1993)

Phenotype Manifest In

cystoblast | heat sensitive

(Coyle-Thompson and Banerjee, 1993)

eye | heat sensitive

(Coyle-Thompson and Banerjee, 1993)

eye photoreceptor cell | heat sensitive

(Coyle-Thompson and Banerjee, 1993)

leg | heat sensitive

(Coyle-Thompson and Banerjee, 1993)

mesothoracic tarsal segment 4 | heat sensitive

(Coyle-Thompson and Banerjee, 1993)

mesothoracic tarsal segment 5 | heat sensitive

(Coyle-Thompson and Banerjee, 1993)

metathoracic tarsal segment 4 | heat sensitive

(Coyle-Thompson and Banerjee, 1993)

metathoracic tarsal segment 5 | heat sensitive

(Coyle-Thompson and Banerjee, 1993)

ommatidium

(Thumm and Kadowaki, 2001)

ovariole | heat sensitive

(Coyle-Thompson and Banerjee, 1993)

prothoracic tarsal segment 4 | heat sensitive

(Coyle-Thompson and Banerjee, 1993)

prothoracic tarsal segment 5 | heat sensitive

(Coyle-Thompson and Banerjee, 1993)

wing

(Thumm and Kadowaki, 2001)

wing | heat sensitive

(Coyle-Thompson and Banerjee, 1993)

wing margin

(Tsuda et al., 2002, Majumdar et al., 1997)

wing vein

(Thumm and Kadowaki, 2001, Majumdar et al., 1997)

wing vein | heat sensitive

(Coyle-Thompson and Banerjee, 1993)

Detailed Description

Statement

Reference

sno^71e3/Y males show slight notching of the wing and wing vein thickening. The flies also have a rough eye phenotype.

(Thumm and Kadowaki, 2001)

At 23^oC flies exhibit a modest loss of wing margin tissue and thickening of wing veins. Flies heat pulsed during pupariation do not exhibit a hypertrophic bristle phenotype on the notum and photoreceptor organisation behind the morphogenetic furrow is regular.

(Majumdar et al., 1997)

At 23^oC adults have rough eyes: bristles misplaced and sometimes duplicated. 30% of ommatidia have lost one or more R cells, and 30% contained an extra R cell. At 19^oC eyes are more normal. At 23^oC wings are notched and veins are thickened, and this phenotype is more severe at 27^oC and absent at 19^oC. Fourth and fifth tarsal segments are fused with 80% penetrance at 23^oC, and wild type at 19^oC. Females are poorly fertile at 23^oC and completely sterile at 27^oC. At 25^oC the number of ovarioles per female is reduced by 25%, and defects in cystoblast survival and polarity are evident. Temperature sensitive period is in the prepupal and pupal stages. Phenotypes of sno^71e3 are similar to those of N^l1N-ts1.

(Coyle-Thompson and Banerjee, 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

sno^71e3 has visible phenotype, enhanceable by Atg4b^P0997/Atg4b^P0997

(Thumm and Kadowaki, 2001)

Other

Statement

Reference

Su(H)², sno^71e3 has lethal | pupal stage phenotype

(Majumdar et al., 1997)

Su(H)[+]/Su(H)², sno^71e3 has lethal | pupal stage phenotype

(Majumdar et al., 1997)

gro^E73, sno^71e3 has lethal phenotype

(Coyle-Thompson and Banerjee, 1993)

Phenotype Manifest In

Enhanced by

Statement

Reference

sno^71e3 has wing margin phenotype, enhanceable by ebi^k16213

(Tsuda et al., 2002)

sno^71e3 has ommatidium phenotype, enhanceable by Atg4b^P0997/Atg4b^P0997

(Thumm and Kadowaki, 2001)

sno^71e3 has wing vein phenotype, enhanceable by Atg4b^P0997/Atg4b^P0997

(Thumm and Kadowaki, 2001)

sno^71e3 has wing phenotype, enhanceable by Atg4b^P0997/Atg4b^P0997

(Thumm and Kadowaki, 2001)

sno^71e3 has wing margin phenotype, enhanceable by vg[+]/vg¹

(Majumdar et al., 1997)

sno^71e3 has wing margin phenotype, enhanceable by wg^l-12/wg[+]

(Majumdar et al., 1997)

sno^71e3 has wing margin phenotype, enhanceable by ct^53d/ct[+]

(Majumdar et al., 1997)

sno^71e3 has phenotype, enhanceable by N^nd-1

(Coyle-Thompson and Banerjee, 1993)

sno^71e3 has phenotype, enhanceable by N^nd-2

(Coyle-Thompson and Banerjee, 1993)

Suppressed by

Statement

Reference

sno^71e3 has wing margin phenotype, suppressible by H[+]/H^E31

(Majumdar et al., 1997)

sno^71e3 has phenotype, suppressible by H⁹⁹

(Coyle-Thompson and Banerjee, 1993)

NOT suppressed by

Statement

Reference

sno^71e3 has phenotype, non-suppressible by mam¹⁰

(Coyle-Thompson and Banerjee, 1993)

sno^71e3 has phenotype, non-suppressible by bib¹

(Coyle-Thompson and Banerjee, 1993)

sno^71e3 has phenotype, non-suppressible by neur¹¹

(Coyle-Thompson and Banerjee, 1993)

Enhancer of

Statement

Reference

sno^71e3 is an enhancer of phenotype of N^nd-1

(Coyle-Thompson and Banerjee, 1993)

sno^71e3 is an enhancer of phenotype of N^nd-2

(Coyle-Thompson and Banerjee, 1993)

Suppressor of

Statement

Reference

sno^71e3 is a suppressor of wing vein phenotype of Delta³

(Coyle-Thompson and Banerjee, 1993)

sno^71e3 is a suppressor of phenotype of H⁹⁹

(Coyle-Thompson and Banerjee, 1993)

sno^71e3 is a suppressor of phenotype of N^Ax-9

(Coyle-Thompson and Banerjee, 1993)

sno^71e3 is a suppressor of phenotype of N^Ax-E2

(Coyle-Thompson and Banerjee, 1993)

Other

Statement

Reference

gro^E73, sno^71e3 has eye phenotype

(Coyle-Thompson and Banerjee, 1993)

Additional Comments

Genetic Interactions

Statement

Reference

The notching of the wing and wing vein thickening seen in sno^71e3/Y males is enhanced by CG6194^P0997/CG6194^P0997. The sno^71e3/Y rough eye phenotype is also enhanced.

(Thumm and Kadowaki, 2001)

Loss of a single copy of wg (wg^l-12), ct (ct^53d) or vg (vg¹) in sno^71e3 flies causes extensive loss of wing margin tissue. Single copy loss of H (H^E31) is able to suppress the wing margin defects of sno^71e3 flies. Loss of a single copy of Su(H) (Su(H)²) causes pupal lethality at 23^oC and at 20^oC some pupae eclose and exhibit severe wing margin defects.

(Majumdar et al., 1997)

A duplication of N rescues many of the defects of sno mutants. There is a synergistic interaction with 'nd' alleles of N, and a suppressive interaction with alleles of the 'Ax' class of N. H⁹⁹ and sno^71e3 show a mutually suppressive interaction. The confluens phenotype of Dl³ is suppressed by sno^71e3. Flies hemizygous for sno^71e3 and heterozygous for gro^E73 suffer lethality with a few escapers that show an eye roughening phenotype.

(Coyle-Thompson and Banerjee, 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Lefevre and Green.

(Coyle-Thompson and Banerjee, 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

sno^71E3

(Thumm and Kadowaki, 2001, Majumdar et al., 1997)

sno^71e3

(Popodi et al., 2010-)

sno^E3

(Tsuda et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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