FlyBase Allele Report: Dmel\bib[1]

Homozygous clones in adult flies have moderately increased numbers of macrochaetae and microchaetae. These bristles have normal sockets innervated by single neurons.

(Doherty et al., 1997)

Homozygous embryos have an increased number of cardiac precursor cells.

(Jagla et al., 1997)

Embryos exhibit fused muscles in patterned arrangements, particularly in the more dorsal regions of the embryo. The birefringent is clearly correlated with the expansion of the CNS and PNS, and the loss of epidermis and the degree to which myoblast fusion occurs. Where myoblast fusion fails conspicuous clusters of mesodermal cells are formed and if epidermal territories are expanded cells in these clusters may be recruited to fusion.

(Bate et al., 1993)

Sensory neurons, foregut, trachea, endoderm, and larval midgut are wild type.

(Hartenstein et al., 1992)

ac protein distribution in bib¹ embryos show ac expression is not restricted to a single cell of an ectodermal cell cluster, instead most cells of the cluster retain ac expression at a high level, enlarge, delaminate and become neuroblasts.

(Skeath and Carroll, 1992)

bib¹ expression was not modified by the presence of ASC loss-of-function mutations.

(Brand and Campos-Ortega, 1988)

Strong allele.

(Tearle and Nusslein-Volhard, 1987)

Homozygous clones induced in the eye and thoracic imaginal discs show epidermal development indistinguishable from wild-type.

(Dietrich and Campos-Ortega, 1984)

Intermediate embryonic neurogenic phenotype. CNS hypertrophy and epidermal defects are evident in all mutants.

(Lehmann et al., 1983)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

bib¹ is an enhancer of visible phenotype of Nsf2^EQ.UAS, Scer\GAL4^bbg-C96

(Stewart et al., 2001)

Phenotype Manifest In

Enhancer of

Statement

Reference

bib[+]/bib¹ is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, fru^NP0021

(Goto et al., 2011)

bib¹ is an enhancer of wing margin phenotype of Nsf2^EQ.UAS, Scer\GAL4^bbg-C96

(Stewart et al., 2001)

NOT Suppressor of

Statement

Reference

bib¹ is a non-suppressor of phenotype of sno^71e3

(Coyle-Thompson and Banerjee, 1993)

Additional Comments

Genetic Interactions

Statement

Reference

A bib¹ background enhances the rough eye phenotype related to fru isoform B, found upon expression of fru^NP0021 under the control of Scer\GAL4^GMR.PF.

(Goto et al., 2011)

No effect on the faf eye phenotype.

(Huang and Fischer-Vize, 1996)

No significant effect on the sca^MSKF mutant phenotype.

(Hu et al., 1995)

There is no detectable dominant interaction with sno^71e3.

(Coyle-Thompson and Banerjee, 1993)

Does not rescue the lethality conferred by N^Ax-E2/N^Ax-9 heterozygotes.

(Xu et al., 1990)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

1595

106405

Notes on Origin

Discoverer

Nusslein-Volhard and Wieschaus.

Separable from: Mon1^mut4.

(Yousefian et al., 2013)

The Mon1^mut4 allele is a background mutation present on some bib¹ chromosomes, and it accounts for the aberrant protein trafficking phenotype that was erroneously attributed to bib¹ in FBrf0204892.

(Yousefian et al., 2013)

Comments

Phenotype not modified by increasing the number of wild type alleles of amx, neur, N, Dl or E(spl).

(de la Concha et al., 1988)

Clonal analysis indicates that bib functions autonomously to inhibit neural development.

(Doherty et al., 1997)

The bib¹ mutant stock used in FBrf0204892 carries an unlinked mutation that accounts for some of the N-related findings originally attributed to bib in FBrf0204892. FBrf0204892 has thus been retracted. FlyBase curator comment: FBrf0221616 describes the characterisation of the unlinked mutation, showing that it is a mutation in Mon1.

(Kanwar and Fortini, 2010)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

bi^IDO5

(Skeath and Carroll, 1992)

bib¹

(Schwarz et al., 2018, Yamakawa et al., 2018, Yousefian et al., 2013, Goto et al., 2011, Kanwar and Fortini, 2010, Salzer et al., 2010, Christensen et al., 2008.12.28, Christensen and Cook, 2007.3.22, Christensen and Cook, 2006.8.30)

bib^ID05

(Grueber et al., 2003, Johannes and Preiss, 2002, Brewster et al., 2001, Doherty et al., 1997, Jagla et al., 1997, Leviten and Posakony, 1996, Schmid et al., 1996, Johnson et al., 1995, Lord et al., 1995, Lewis and Crews, 1994, Bate et al., 1993, Coyle-Thompson and Banerjee, 1993, Kooh et al., 1993, Hartenstein et al., 1992, Xu et al., 1990, Brand and Campos-Ortega, 1988, de la Concha et al., 1988, Dietrich and Campos-Ortega, 1984, Lehmann et al., 1983)

bib^ID105

(Li and Baker, 2001, Hu et al., 1995)

bib^ID5

(Jacobs et al., 1989, Tearle and Nusslein-Volhard, 1987)

bib^OD05

(Xu and Artavanis-Tsakonas, 1990)

Name Synonyms

Secondary FlyBase IDs

References (40)

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