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Citation
Kanwar, R., Fortini, M.E. (2008). The big brain aquaporin is required for endosome maturation and notch receptor trafficking.  Cell 133(5): 852--863.
FlyBase ID
FBrf0204892
Publication Type
Research paper
Abstract
Activity of the big brain (bib) gene influences Notch signaling during Drosophila nervous system development. We demonstrate that Bib, which belongs to the aquaporin family of channel proteins, is required for endosome maturation in Drosophila epithelial cells. In the absence of Bib, early endosomes arrest and form abnormal clusters, and cells exhibit reduced acidification of endocytic trafficking organelles. Bib acts downstream of Hrs in early endosome morphogenesis and regulates biogenesis of endocytic compartments prior to the formation of Rab7-containing late endosomes. Abnormal endosome morphology caused by loss of Bib is accompanied by overaccumulation of Notch, Delta, and other signaling molecules as well as reduced intracellular trafficking of Notch to nuclei. Analysis of several endosomal trafficking mutants reveals a correlation between endosomal acidification and levels of Notch signaling. Our findings reveal an unprecedented role for an aquaporin in endosome maturation, trafficking, and acidification.
PubMed ID
18510929
PubMed Central ID
PMC2488160 (PMC) (EuropePMC)
DOI
10.1016/j.cell.2008.04.038
Related Publication(s)
Retraction

Retraction Notice to: The big brain aquaporin is required for endosome maturation and notch receptor trafficking.
Kanwar and Fortini, 2010, Cell 142(1): 170 [FBrf0221812]

Associated Information
Comments

THIS PAPER HAS BEEN RETRACTED, because phenotypes attributed to bib1 in the paper have since been shown to be due to a second-site mutation, shown in FBrf0221616 to be a mutation in Mon1 (see the associated retraction, FBrf0221812). The original description of the P{UAS-N.V5} transgenic construct in this retracted paper remains valid and is associated with the original paper in FlyBase, all other data has been removed.

Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Alleles (1)
    Genes (1)
    Experimental Tools (3)
    Transgenic Constructs (1)