FlyBase Allele Report: Dmel\Sos[x122]

General Information

Symbol

Dmel\Sos^x122

Species

D. melanogaster

Name

FlyBase ID

FBal0030260

Feature type

allele

Associated gene

Dmel\Sos

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Rogge et al., 1991)

loss of function allele

(Lu et al., 1993)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | cell autonomous | somatic clone

(Firth and Baker, 2005)

lethal - all die during embryonic stage | recessive

(Rogge et al., 1991)

some die during embryonic stage | recessive

(Rogge et al., 1991)

visible | recessive

(Lu and Li, 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

Sos^x122 homozygous clones in the dorsal air sac primordium grow more slowly than wild-type clones and never contribute to the tip of the primordium.

(Cabernard and Affolter, 2005)

Additional cells enter the second mitotic wave in Sos^x122 clones.

(Firth and Baker, 2005)

Sos^x122/Sos^AM14 flies show loss of wing veins.

(Lu and Li, 1999)

Clonal analysis reveals phenotypes in the adult including loss of wing vein, ectopic wing vein, reduced cell size, extra bristles and cell lethality.

(Diaz-Benjumea and Hafen, 1994)

Defects in the developing central and peripheral nervous system, partial disruption of axon tracts in the commissures and in the longitudinal connectives and disorganisation of sense organ neurons. Heteroallelic combination Sos^x122/Sos^34Ea-7 displays an extreme rough eye phenotype, many R cells are missing and combination Sos^x122/Sos^ex63 displays a weak rough eye phenotype, R7 cells are missing.

(Rogge et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Sos^x122 has visible | recessive phenotype, suppressible by Src42A^Su(Raf)1-1

(Lu and Li, 1999)

Suppressor of

Statement

Reference

Sos^x122/Sos[+] is a suppressor of visible phenotype of Scer\GAL4^en-e16E, Socs44A^UAS.cRa

(Rawlings et al., 2004)

Other

Statement

Reference

Sos^x122, Su(H)^del47 has abnormal mitotic cell cycle | somatic clone | cell autonomous phenotype

(Firth and Baker, 2005)

Phenotype Manifest In

Suppressed by

Statement

Reference

Sos^x122 has eye phenotype, suppressible by Src42A^Su(Raf)1-1

(Lu and Li, 1999)

Sos^x122 has wing vein phenotype, suppressible by Src42A^7-4

(Lu and Li, 1999)

Suppressor of

Statement

Reference

Sos^x122/Sos[+] is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^en-e16E, Socs44A^UAS.cRa

(Rawlings et al., 2004)

Sos^x122/Sos[+] is a suppressor of phenotype of Src42A^Su(Raf)1-1

(Zhang et al., 1999)

Sos^x122 is a suppressor of photoreceptor cell R1 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Sos^x122 is a suppressor of photoreceptor cell R2 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Sos^x122 is a suppressor of photoreceptor cell R3 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Sos^x122 is a suppressor of photoreceptor cell R4 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Sos^x122 is a suppressor of photoreceptor cell R5 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Sos^x122 is a suppressor of photoreceptor cell R6 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Sos^x122 is a suppressor of phenotype of Src42A^KR.hs.2sev

(Takahashi et al., 1996)

NOT Suppressor of

Statement

Reference

Sos^x122 is a non-suppressor of photoreceptor cell R7 phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

Other

Statement

Reference

Sos^x122, Su(H)^del47 has eye disc | somatic clone | cell autonomous phenotype

(Firth and Baker, 2005)

S⁵⁴, Sos^x122 has ommatidium phenotype

(Kolodkin et al., 1994)

S⁵⁴, Sos^x122 has eye photoreceptor cell phenotype

(Kolodkin et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

No second mitotic wave is observed in Su(H)^del47, Sos^x122 clones.

(Firth and Baker, 2005)

The ectopic wing vein phenotype caused by expression of Socs44A^Scer\UAS.cRa under the control of Scer\GAL4^en-e16E is suppressed by Sos^x122/+.

(Rawlings et al., 2004)

Src42A^Su(phl)1-1 dominantly suppresses the rough eye phenotype of Sos^x122/Sos^AM14. The Sos^x122/Sos^AM14 wing vein phenotype is partially suppressed by one copy of Src42A^7-4.

(Lu and Li, 1999)

Dominantly suppresses the ability of Src42A^Su(phl)1-1 to suppress the lethality of phl¹/Y flies.

(Zhang et al., 1999)

Sos^x122 significantly suppresses the formation of extra outer photoreceptors caused by B-H1^sev.PH, although it does not affect the loss of R7 cell phenotype caused by B-H1^sev.PH.

(Hayashi et al., 1998)

Although Sos⁺/Sos^x122 shows no phenotype, S⁵⁴, Sos⁺/S⁺,Sos^x122 shows a significantly increased numbers of ommatidia with incomplete sets of R cells.

(Kolodkin et al., 1994)

Sos^x122 gene product is capable of suppressing the sev⁶ phenotype but the level of suppression is lower than that provided by the wild type Sos protein.

(Rogge et al., 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Sos^x122 is rescued by Sos^+t15.1

(Bonfini et al., 1992)

Comments

The Sos^x122 lethal phenotype is rescued by Sos^+t15.1.

(Bonfini et al., 1992)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

R. Rogge.

(Chou et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Sos^X122

(Firth and Baker, 2005, del Alamo et al., 2002, Li et al., 2000, Lu and Li, 1999, Hayashi et al., 1998, Diaz-Benjumea and Hafen, 1994)

Sos^x122

(Cabernard and Affolter, 2005, Rawlings et al., 2004)

X122

(Chou et al., 1993)

sos^X122

(Zhang et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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