FlyBase Allele Report: Dmel\S[54]

General Information

Symbol

Dmel\S⁵⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0015111

Feature type

allele

Associated gene

Dmel\S

Associated Insertion(s)

Carried in Construct

Also Known As

S^l(2)54

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q387term.

(Tsruya et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:1,052,808..1,052,808 [-]

Nucleotide change:

C1052808T

Amino acid change:

Q387term | S-PA; Q387term | S-PB

Reported amino acid change:

Q387term

(Tsruya et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(Gonzalez-Gaitan and Jackle, 2000)

visible | dominant

(Kotarski et al., 1998)

Phenotype Manifest In

embryonic/larval stomatogastric nervous system

(Gonzalez-Gaitan and Jackle, 2000)

eye

(Kotarski et al., 1998, Kolodkin et al., 1994)

ommatidium

(Kotarski et al., 1998, Kolodkin et al., 1994)

stomodeal invagination

(Gonzalez-Gaitan and Jackle, 2000)

Detailed Description

Statement

Reference

The stomatogastric nervous system (SNS) anlage forms normally in mutant embryos. However, the stomodeal invaginations that are seen in wild-type stage 11 embryos are not seen in mutant embryos at this stage. Stage 17 mutant embryos lack SNS ganglia and nerves.

(Gonzalez-Gaitan and Jackle, 2000)

Heterozygotes have smaller eyes than normal and the regular arrangement of facets is disrupted.

(Kotarski et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

S⁵⁴ has visible | dominant phenotype, enhanceable by ast^K6/ast[+]

(Kotarski et al., 1998)

Enhancer of

Statement

Reference

S⁵⁴/S[+] is an enhancer of visible phenotype of rg^γ6

(Shamloula et al., 2002)

Suppressor of

Statement

Reference

S⁵⁴/S[+] is a suppressor of visible | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

S⁵⁴ has eye phenotype, enhanceable by ast^K6/ast[+]

(Kotarski et al., 1998)

S⁵⁴ has ommatidium phenotype, enhanceable by ast^K6/ast[+]

(Kotarski et al., 1998)

Enhancer of

Statement

Reference

S⁵⁴/S[+] is an enhancer of eye phenotype of rg^γ6

(Shamloula et al., 2002)

NOT Enhancer of

Statement

Reference

S⁵⁴ is a non-enhancer of eye phenotype of N^spl-1

(Nagel and Preiss, 1999)

Suppressor of

Statement

Reference

S⁵⁴/S[+] is a suppressor of wing vein | ectopic | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

S⁵⁴/S[+] is a suppressor of wing | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

Other

Statement

Reference

S⁵⁴, Sos^x122 has ommatidium phenotype

(Kolodkin et al., 1994)

S⁵⁴, Sos^x122 has eye photoreceptor cell phenotype

(Kolodkin et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Has no effect on the eye phenotype of N^spl-1.

(Nagel and Preiss, 1999)

The eye phenotype of S⁵⁴ heterozygotes is dominantly enhanced by ast^K6.

(Kotarski et al., 1998)

Although Sos⁺/Sos^x122 shows no phenotype, S⁵⁴, Sos⁺/S⁺, Sos^x122 shows a significantly increased numbers of ommatidia with incomplete sets of R cells.

(Kolodkin et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

S⁵⁴ is rescued by S^{UAS.TMC.Tag:HA}/Scer\GAL4^GMR.PF

(Tsruya et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

S⁵⁴

(Gonzalez-Gaitan and Jackle, 2000)

S^e(2)54

(Noll et al., 1994)

S^l(2)54

(Edgar et al., 1994, Noll et al., 1994)

Name Synonyms

Secondary FlyBase IDs

FBal0039008
FBal0039013

References (13)

Report Sections

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