FlyBase Allele Report: Dmel\csw[Esev1A-eOP]

General Information

Symbol

Dmel\csw^Esev1A-eOP

Species

D. melanogaster

Name

FlyBase ID

FBal0029640

Feature type

allele

Associated gene

Dmel\csw

Associated Insertion(s)

Carried in Construct

Also Known As

E(sev)1A^e0P, csw^eOP, csw^e0P, csw^G547E

Key Links

Genomic Maps

JBrowse

Allele class

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Jarvis et al., 2006, Allard et al., 1996, Cooper et al., 1996, Carroll et al., 1995)

Mutagen

ethyl methanesulfonate

(Perkins et al., 1996)

Progenitor genotype

Cytology

Description

Mutation is within the csw PTP domain.

(Allard et al., 1996)

Nucleotide substitution: G?A.

(Allard et al., 1996)

Amino acid replacement: G547E.

(Allard et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:2,110,578..2,110,578 [+]

Nucleotide change:

G2110578A

Amino acid change:

G547E | csw-PA; G647E | csw-PB; G388E | csw-PC; G600E | csw-PD

(Allard et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | germline clone

(Tsuda et al., 1993)

lethal | recessive

(Allard et al., 1996, Cooper et al., 1996)

lethal - all die before end of pupal stage | recessive

(Perkins et al., 1996)

some die during pupal stage | recessive

(Perkins et al., 1996)

visible | dominant

(Allard et al., 1996, Cooper et al., 1996)

Phenotype Manifest In

eye

(Allard et al., 1996)

mesoderm | germline clone

(Wilson et al., 2005)

photoreceptor cell R7

(Cooper et al., 1996)

Detailed Description

Statement

Reference

The mesoderm of homozygous embryos derived from homozygous female germline clones is able to establish contact with the ectoderm, but the overall appearance of the invaginated mesodermal tube is abnormal.

(Wilson et al., 2005)

Mutation disrupts development of receptor cell R7.

(Cooper et al., 1996)

Removal of one copy of csw from sev::tor^{13D:Y2546F.hs.sev} individuals causes a very significant reduction in ommatidia with multiple R7 cells.

(Raabe et al., 1996)

Overexpression results in loss of photoreceptor cells.

(Allard and Simon, 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

csw^Esev1A-eOP has lethal | germline clone phenotype, suppressible by Dsor1^Su1

(Tsuda et al., 1993)

NOT Enhancer of

Statement

Reference

csw^Esev1A-eOP is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Suppressor of

Statement

Reference

csw^Esev1A-eOP/csw[+] is a suppressor of visible phenotype of Scer\GAL4^c684, if^m8.UAS

(Baker et al., 2002)

csw^Esev1A-eOP is a suppressor of visible phenotype of if^m8.αTub84B

(Baker et al., 2002)

csw^Esev1A-eOP/csw[+] is a suppressor of visible phenotype of Src64B^Δ540.hs.sev

(Cooper et al., 1996)

NOT Suppressor of

Statement

Reference

csw^Esev1A-eOP is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

csw^Esev1A-eOP is an enhancer of ganglionic tracheal branch primordium phenotype of bnl^unspecified

(Jarvis et al., 2006)

csw^Esev1A-eOP is an enhancer of phenotype of svp^hs.ro1

(Kramer et al., 1995)

NOT Enhancer of

Statement

Reference

csw^Esev1A-eOP is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Suppressor of

Statement

Reference

csw^Esev1A-eOP/csw[+] is a suppressor of wing phenotype of Scer\GAL4^c684, if^m8.UAS

(Baker et al., 2002)

csw^Esev1A-eOP is a suppressor of wing phenotype of if^m8.αTub84B

(Baker et al., 2002)

csw^Esev1A-eOP/csw[+] is a suppressor of eye phenotype of Src64B^Δ540.hs.sev

(Cooper et al., 1996)

csw^Esev1A-eOP is a suppressor of phenotype of Src42A^KR.hs.2sev

(Takahashi et al., 1996)

csw^Esev1A-eOP is a suppressor of phenotype of svp^2.sev

(Begemann et al., 1995, Kramer et al., 1995)

NOT Suppressor of

Statement

Reference

csw^Esev1A-eOP is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

csw^Esev1A-eOP enhances the ganglionic branch outgrowth phenotype of bnl^unspecified/+ embryos.

(Jarvis et al., 2006)

The wing blistering caused by expression of if^m8.αTub84B is suppressed by csw^Esev1A-eOP/+. The wing blistering caused by expression of if^m8.Scer\UAS under the control of Scer\GAL4^337Y is suppressed by csw^Esev1A-eOP/+.

(Baker et al., 2002)

Presence of the mutation in Src64B^Δ540.hs.sev flies alleviates the rough eye phenotype.

(Cooper et al., 1996)

Suppressor of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

(Begemann et al., 1995)

Suppression of the rough eye phenotype (formation of extra R7 cells) caused by P{sev-svp2} and enhancement of the P{ro-svp1} rough eye phenotype (loss of one or more outer photoreceptors from many of the ommatidia).

(Kramer et al., 1995)

Half of the embryos derived from homozygous germ line clones can be rescued by Dsor1^Su1, other fail to hatch despite the normal cuticle pattern.

(Tsuda et al., 1993)

Slightly enhances the sev^B4 phenotype: disrupts sev^B4 protein signalling.

(Simon et al., 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

csw^Esev1A-eOP is rescued by csw^hs.2sev

(Allard et al., 1996)

Comments

Lethality and eye phenotype is rescued by csw^hs.2sev.

(Allard et al., 1996)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Dominant mutation that attenuates signalling by a temperature sensitive sev allele.

(Carroll et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

Csw^G547E

(Feng, 1999)

E(sev)1A^e0P

(Allard et al., 1996, Allard et al., 1996, Takahashi et al., 1996, Begemann et al., 1995)

E(sev)1A^eOP

(Tsuda et al., 1993)

csw^E(sev)1A-eOP

(Wilson et al., 2005)

csw^E(sev)1A

(Raabe et al., 1996)

csw^Esev1A-eOP

csw^G547E

(Jarvis et al., 2006, Cooper et al., 1996)

csw^dn

(Carroll et al., 1995)

csw^e0P

(Hayashi et al., 1998, Kramer et al., 1995)

csw^eOP

(Baker et al., 2002, Perkins et al., 1996)

Name Synonyms

Secondary FlyBase IDs

References (18)

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