FlyBase Allele Report: Dmel\kni[ri-1]

General Information

Symbol

Dmel\kni^ri-1

Species

D. melanogaster

Name

FlyBase ID

FBal0014568

Feature type

allele

Associated gene

Dmel\kni

Associated Insertion(s)

Carried in Construct

Also Known As

ri¹, kni^ri

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

252bp deletion (coordinates 3L:20707101..20707352 , release 6 sequence).

(Miller et al., 2016)

252bp deletion within fragment "E" of the kni putative upstream regulatory sequences.

(Lunde et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:20,707,101..20,707,352 [-]

Comment:

252bp deletion in the putative regulatory region for wing vein L2 expression.

(Lunde et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Rendina et al., 2010, Lunde et al., 2003)

visible | recessive

(Lunde et al., 1998)

Phenotype Manifest In

wing

wing vein L2

(Angulo et al., 2004, Lunde et al., 2003, Lunde et al., 1998)

wing vein L2 | distal

(Rendina et al., 2010)

Detailed Description

Statement

Reference

Homozygous flies lack the distal part of wing vein L2.

(Rendina et al., 2010)

The wings of kni^ri-1/kni^ri-1 flies lack most of L2.

(Angulo et al., 2004)

Homozygous adults have a severely truncated L2 wing vein.

(Lunde et al., 2003)

Homozygous flies show loss of wing vein L2. The L2 wing vein truncation phenotype is rescued with high penetrance by kni^Scer\UAS.cLa expressed under the control of Scer\GAL4^Bx-MS1096 or by kni^EP, but the rescued vein is consistently displaced anteriorly relative to the normal position of the L2 vein. kni^ri-1/In(3L)ri^XT101 flies have a strong "ri" phenotype.

(Lunde et al., 1998)

RK1. Vein L2 interrupted. Wings slightly warped and blunt.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

kni^ri-1 has visible phenotype, suppressible by Bap170^hfl1/Bap170[+]

(Rendina et al., 2010)

kni^ri-1 has visible phenotype, suppressible by eg^UAS.cDa/Scer\GAL4^kni.L2

(Lunde et al., 2003)

kni^ri-1 has visible phenotype, suppressible by rho^UAS.cBa/Scer\GAL4^kni.L2

(Lunde et al., 2003)

kni^ri-1 has visible phenotype, suppressible by knrl^UAS.cLa/Scer\GAL4^kni.L2

(Lunde et al., 2003)

Suppressor of

Statement

Reference

kni^ri-1 is a suppressor of visible | recessive phenotype of salm¹

(Lunde et al., 1998)

Phenotype Manifest In

Suppressed by

Statement

Reference

kni^ri-1 has wing vein L2 | distal phenotype, suppressible by Bap170^hfl1/Bap170[+]

(Rendina et al., 2010)

kni^ri-1 has wing vein L2 phenotype, suppressible by ash2^S112411/ash2^S112411

(Angulo et al., 2004)

kni^ri-1 has wing vein L2 phenotype, suppressible by eg^UAS.cDa/Scer\GAL4^kni.L2

(Lunde et al., 2003)

kni^ri-1 has wing vein L2 phenotype, suppressible by knrl^UAS.cLa/Scer\GAL4^kni.L2

(Lunde et al., 2003)

kni^ri-1 has wing vein L2 phenotype, suppressible by rho^UAS.cBa/Scer\GAL4^kni.L2

(Lunde et al., 2003)

NOT Enhancer of

Statement

Reference

kni[+]/kni^ri-1 is a non-enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

Suppressor of

Statement

Reference

kni^ri-1 is a suppressor of wing vein L2 | ectopic phenotype of salm¹

(Lunde et al., 1998)

NOT Suppressor of

Statement

Reference

kni[+]/kni^ri-1 is a non-suppressor of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

kni^ri-1 is a non-suppressor of dorsal row of triple row of wing sensilla | ectopic phenotype of salm¹

(Lunde et al., 1998)

kni^ri-1 is a non-suppressor of medial row of triple row of wing sensilla | ectopic phenotype of salm¹

(Lunde et al., 1998)

kni^ri-1 is a non-suppressor of ventral row of triple row of wing sensilla | ectopic phenotype of salm¹

(Lunde et al., 1998)

Other

Statement

Reference

Bant\lef^UAS.cGa, Scer\GAL4^Bx-MS1096, kni^ri-1 has wing vein phenotype

(Guichard et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The loss of the distal part of wing vein L2 which is seen in kni^ri-1 homozygotes is almost completely suppressed by Bap170^hfl1/+ in 95% of cases.

(Rendina et al., 2010)

ash2^S112411/ash2^S112411 suppresses the loss of L2 seen in kni^ri-1/kni^ri-1 flies.

(Angulo et al., 2004)

Expression of knrl^Scer\UAS.cLa under the control of Scer\GAL4^kni.L2 rescues the L2 wing vein phenotype of kni^ri-1 flies. Expression of rho^Scer\UAS.cBa under the control of Scer\GAL4^kni.L2 rescues the L2 wing vein phenotype of kni^ri-1 flies. Expression of eg^Scer\UAS.cDa under the control of Scer\GAL4^kni.L2 restores wing vein L2 formation in kni^ri-1 flies. The restored L2 vein is decorated with a line of ectopic sensory bristles (these ectopic bristles are also seen when eg^Scer\UAS.cDa is expressed under the control of Scer\GAL4^kni.L2 in a wild-type background).

(Lunde et al., 2003)

Homozygous salm¹ clones between veins L2 and L3 have an ectopic vein L2 fork running within and along the clone boundary. These ectopic L2 forks are not induced by homozygous salm¹ clones in a kni^ri-1 background. Homozygous salm¹ clones which intersect the wing margin are associated with ectopic islands of triple row bristles. This phenotype is induced by salm¹ clones in a kni^ri-1 background.

(Lunde et al., 1998)

Xenogenetic Interactions

Statement

Reference

Moderate expression of Zzzz\lef^Scer\UAS.cGa under the control of Scer\GAL4^Bx-MS1096 in kni^ri-1 heterozygotes results in wing vein loss, while moderate Zzzz\lef^Scer\UAS.cGa expression (with Scer\GAL4^Bx-MS1096) alone doesn't have this phenotype.

(Guichard et al., 2006)

Complementation and Rescue Data

Fails to complement

kni^ri-XT2

(Lunde et al., 1998)

Rescued by

kni^ri-1 is rescued by kni^UAS.cLa/Scer\GAL4^kni.L2

(Lunde et al., 2003)

Partially rescued by

kni^ri-1 is partially rescued by kni^UAS.cLa/Scer\GAL4^Bx-MS1096

(Lunde et al., 1998)

Comments

kni¹, kni³, kni⁸ and kni⁹ fail to complement kni^ri-1 when it is carried on a chromosome such as TM3 or In(3LR)LD6 that is rearranged with respect to the kni¹, kni³, kni⁸ or kni⁹ mutant chromosome. kni¹, kni³, kni⁸ and kni⁹ fully complement kni^ri-1 when the kni^ri-1 and kni¹, kni³, kni⁸ or kni⁹ alleles are carried on non-rearranged chromosomes.

(Lunde et al., 1998)

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (327)

Bloomington

566

kni^ri-1

738

kni^ri-1 e¹

718

C(3L)RM-P3, kni^ri-1; C(3R)RM-P3

704

Df(3R)M35, kni^ri-1/TM3, Sb¹

6178

k^D e^s/TM2, kni^ri-1

907

Df(3R)M312, kni^ri-1/TM3, Sb¹

1048

DNase2ⁿ¹ kni^ri-1 p^p

5743

Dp(3;3)Cam31, kni^ri-1 p^p/TM1

Kyoto

101731

kni^ri-1 ss¹

106041

Df(3R)M35, kni^ri-1/TM3, Sb¹

106114

Df(3R)M312, kni^ri-1/TM3, Sb¹

101642

gl¹ k^D / TM2, kni^ri-1

More stocks available...

Notes on Origin

Discoverer

Tshetverikov, 1926.

Comments

kni^ri-1, kni^ri-92f and kni^riM have the same lesion.

(Lunde et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

kni^ri-1

(Miller et al., 2016, Harumoto et al., 2014, Kuert et al., 2014, Pilgram et al., 2011, Rendina et al., 2010, Christensen et al., 2009.5.6, Christensen et al., 2009.5.6, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Cook et al., 2008.9.3, Angulo et al., 2004)

kni^ri1

(Matakatsu et al., 1999)

kni^ri

(Rendina et al., 2010, Guichard et al., 2006)

kni^ri[1]

(Lunde et al., 2003)

ri¹

(Lunde et al., 2003, Biehs et al., 1998, Lunde et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (26)

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