FlyBase Allele Report: Dmel\pll[7]

General Information

Symbol

Dmel\pll⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0013861

Feature type

allele

Associated gene

Dmel\pll

Associated Insertion(s)

Carried in Construct

Also Known As

pll³⁸⁵

Key Links

Genomic Maps

JBrowse

Allele class

antimorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Hecht and Anderson, 1993)

loss of function allele

(Shelton and Wasserman, 1993)

Mutagen

ethyl methanesulfonate

(Hecht and Anderson, 1993, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Amino acid replacement: I362F.

(Towb et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:27,251,753..27,251,753 [-]

Nucleotide change:

A27251753T

Amino acid change:

I362F | pll-PA; I362F | pll-PB

Reported amino acid change:

I362F

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Towb et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with pll²)

(Minidorff et al., 2007)

abnormal neuroanatomy (with pll²⁵)

(Minidorff et al., 2007)

abnormal size | embryonic stage

(Irish and Gelbart, 1987)

lethal | maternal effect | recessive

(Hecht and Anderson, 1993)

Phenotype Manifest In

axon & eye photoreceptor cell (with pll²)

(Minidorff et al., 2007)

axon & eye photoreceptor cell (with pll²⁵)

(Minidorff et al., 2007)

embryonic/larval somatic muscle cell

(Halfon and Keshishian, 1998)

embryonic ventral epidermis

(Galindo et al., 1995)

filzkorper

(Irish and Gelbart, 1987)

lamina (with pll²)

(Minidorff et al., 2007)

lamina (with pll²⁵)

(Minidorff et al., 2007)

macrochaeta

(Irish and Gelbart, 1987)

medulla (with pll²)

(Minidorff et al., 2007)

medulla (with pll²⁵)

(Minidorff et al., 2007)

posterior spiracle primordium

(Irish and Gelbart, 1987)

Detailed Description

Statement

Reference

pll⁷/pll² and pll⁷/pll²⁵ larvae show show mistargeting of the R2-R5 photoreceptor axons in the developing visual system; thickened bundles of axons along the entire length of the lamina are observed to penetrate into the medulla, while the lamina is not smooth and is somewhat irregular.

(Minidorff et al., 2007)

The ability of pll⁷/pll² larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.

(Sorrentino et al., 2004)

Homozygous and pll⁷/pll²⁵ larvae have significantly higher levels of muscle defects than wild-type larvae.

(Halfon and Keshishian, 1998)

Embryos from mutant mothers develop only dorsal epidermis.

(Galindo et al., 1995)

Homozygotes and heterozygotes with Df(3R)R38.3 have a completely dorsalised phenotype and a stronger dorsalised phenotype when heterozygous with pll¹⁶.

(Hecht and Anderson, 1993)

Embryos derived from homozygous females are dorsalised.

(Carroll et al., 1987)

dpp^Hin embryos derived from pll⁷ mothers have a dorsalizing phenotype: dorsal setae covering the entire body, rudimentary posterior spiracles lacking Filzkorper and numerous ventral like setae. Individuals have an elongated and convoluted appearance.

(Irish and Gelbart, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

pll⁷ has embryo | ventral phenotype, non-suppressible by tor::tub^t4021t

(Galindo et al., 1995)

Enhancer of

Statement

Reference

pll⁷/pll[+] is an enhancer of embryonic ventral epidermis | non-rescuable maternal effect | germline clone phenotype of wek^EX14

(Chen et al., 2006)

pll⁷/pll[+] is an enhancer of embryonic/first instar larval cuticle | ventral | non-rescuable maternal effect | germline clone phenotype of wek^EX14

(Chen et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The variable dorsalized embryonic phenotype of wek^EX14 mutants is enhanced by pll⁷. While 51% of wek^EX14 embryos show an extreme dorsalized phenotype, this penetrance is increased to 92% in wek^EX14; pll⁷/+ embryos.

(Chen et al., 2006)

Double mutant combinations with ea^D1 are strongly dorsalized.

(Chasan et al., 1992)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

3112

106853

Notes on Origin

Discoverer

Comments

Strong pll allele.

(Hecht and Anderson, 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

385

(Riede, 2001)

pelle⁷

(Chen et al., 2006)

pll^385-13

(Irish and Gelbart, 1987)

pll³⁸⁵

(Sorrentino et al., 2004, Towb et al., 2001, Halfon and Keshishian, 1998, Misra et al., 1998, Yip et al., 1997, Galindo et al., 1995, Gillespie and Wasserman, 1994, Morisato and Anderson, 1994, Hecht and Anderson, 1993, Shelton and Wasserman, 1993, Whalen and Steward, 1993, Chasan et al., 1992, Carroll et al., 1987, Tearle and Nusslein-Volhard, 1987)

pll⁷

(Louradour et al., 2017, Minidorff et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (23)

Report Sections

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