FlyBase Allele Report: Dmel\heph[03429]

General Information

Symbol

Dmel\heph⁰³⁴²⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0009467

Feature type

allele

Associated gene

Dmel\heph

Associated Insertion(s)

P{PZ}heph⁰³⁴²⁹

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}heph⁰³⁴²⁹

Cytology

Description

P{PZ} insertion in a large intron of heph.

(Dansereau et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:31,930,546..31,930,546 [+]

(Besse et al., 2009, Sofola et al., 2007, Dansereau et al., 2002, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Dansereau et al., 2002, Spradling et al., 1999, BDGP Project Members, 1994-1999)

male sterile (with heph²)

(Cook, 2006.1.31, Dansereau et al., 2002)

visible | somatic clone

(Dansereau et al., 2002)

Phenotype Manifest In

embryonic head | germline clone

(Besse et al., 2009)

wing | somatic clone

(Dansereau et al., 2002)

wing margin | ectopic | somatic clone

(Dansereau et al., 2002)

wing margin | somatic clone

(Dansereau et al., 2002)

wing vein | cell autonomous | somatic clone

(Dansereau et al., 2002)

Detailed Description

Statement

Reference

57.4% of embryos derived from homozygous female germline clones stop developing before cuticle formation, and 27.7% show severe morphological defects that prevents analysis of the head. 12% of the analysable embryos lack head structures.

(Besse et al., 2009)

Homozygous clones result in autonomous loss of wing vein differentiation. Wing veins are only completely missing when dorsal and ventral clones coincide. Homozygous clones induce ectopic wing margin. Dorsal or ventral clones that apparently intersect the normal margin result in nicks in the wing margin. Occasionally, clones that induce ectopic wing margin also induce small outgrowths and overgrowth of adjacent wing tissue.

(Dansereau et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

heph⁰³⁴²⁹ is a non-enhancer of visible | somatic clone phenotype of Delta^RevF10

(Dansereau et al., 2002)

Suppressor of

Statement

Reference

heph[+]/heph⁰³⁴²⁹ is a suppressor of visible | dominant phenotype of fng^D4

(Dansereau et al., 2002)

NOT Suppressor of

Statement

Reference

heph⁰³⁴²⁹ is a non-suppressor of visible | somatic clone phenotype of Delta^RevF10

(Dansereau et al., 2002)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

heph⁰³⁴²⁹ is a non-enhancer of wing vein | somatic clone phenotype of Delta^RevF10

(Dansereau et al., 2002)

Suppressor of

Statement

Reference

heph[+]/heph⁰³⁴²⁹ is a suppressor of wing margin phenotype of fng^D4

(Dansereau et al., 2002)

heph[+]/heph⁰³⁴²⁹ is a suppressor of wing phenotype of fng^D4

(Dansereau et al., 2002)

NOT Suppressor of

Statement

Reference

heph⁰³⁴²⁹ is a non-suppressor of wing vein | somatic clone phenotype of Delta^RevF10

(Dansereau et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The loss of wing margin seen in fng^D4/+ flies is partially rescued by heph⁰³⁴²⁹. Clones mutant for both heph⁰³⁴²⁹ and Dl^RevF10 have an autonomous thick veins phenotype and are associated with non-autonomous vein differentiation in neighbouring tissue, as occurs in Dl^RevF10 single mutant clones.

(Dansereau et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

heph²

(Cook, 2006.1.31)

heph²

(Dansereau et al., 2002)

heph^s3441

(BDGP Project Members, 1994-1999)