FB2024_03 , released June 25, 2024
Allele: Dmel\Cap-G49Ff-1
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General Information
Symbol
Dmel\Cap-G49Ff-1
Species
D. melanogaster
Name
FlyBase ID
FBal0009067
Feature type
allele
Associated gene
Dmel\Cap-G
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)49Ff1
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lasko and Pardue, 1988)
Progenitor genotype
Cytology
Description

Amino acid replacement: R343term.

(Jager et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:13,134,486..13,134,486 [+]
Nucleotide change:

A13134486T

Amino acid change:

R343term | Cap-G-PF; R343term | Cap-G-PG

Reported amino acid change:

R343term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Jager et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      One copy of Cap-G49Ff-1 is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)wm4.

      One copy of Cap-G49Ff-1 is unable to suppress the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

      (Doheny et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      l(2)49Ff[+]/Cap-G49Ff-1 is an enhancer of visible phenotype of Scer\GAL4GMR.PF, cidUAS.cJa

      (Jager et al., 2005)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      l(2)49Ff[+]/Cap-G49Ff-1 is an enhancer of eye phenotype of Scer\GAL4GMR.PF, cidUAS.cJa

      (Jager et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Su(z)25

      (Doheny et al., 2008)
      Rescued by

      Cap-G49Ff-1/Cap-G49Ff-6 is rescued by Cap-GUAS.FL.EGFP/Scer\GAL4da.G32

      (Herzog et al., 2013)

      Cap-G49Ff-1/Cap-G49Ff-6 is rescued by Scer\GAL4da.G32/Cap-GNM.UAS.EGFP

      (Herzog et al., 2013)

      Cap-G49Ff-1/Cap-G49Ff-6 is rescued by Cap-GNM.UASp.EGFP/Scer\GAL4da.G32

      (Herzog et al., 2013)
      Partially rescued by

      Cap-G49Ff-1/Cap-G49Ff-6 is partially rescued by Cap-GUASp.cJa/Scer\GAL4da.G32

      (Jager et al., 2005)
      Comments

      Expression of Cap-GNM.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4da.G32 rescues the lethality of Cap-G49Ff-1/Cap-G49Ff-6 animals, with adult flies being obtained with high efficiency.

      Expression of Cap-GNM.Scer\UAS.P\T.T:Avic\GFP-EGFP under the control of Scer\GAL4da.G32 rescues the lethality of Cap-G49Ff-1/Cap-G49Ff-6 animals and fertility is restored in both sexes.

      (Herzog et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Lasko.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Cap-G1
      (Herzog et al., 2013)
      Cap-G49Ff-1
      l(2)11
      l(2)49Ff1
      (Doheny et al., 2008, Jager et al., 2005)
      vr9-11
      (Renn et al., 1998)
      vr911
      (Wu and Howe, 1995)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)