FB2024_03 , released June 25, 2024
Allele: Dmel\Su(z)25
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General Information
Symbol
Dmel\Su(z)25
Species
D. melanogaster
Name
FlyBase ID
FBal0028573
Feature type
allele
Associated gene
Dmel\Su(z)2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Cheng et al., 1994)
Mutagen
gamma ray
(Wu and Howe, 1995)
Progenitor genotype
Caused by aberration
Df(2R)Su(z)25
Cytology
Description

Deletion extends from 3' flanking sequences of the vg locus.

(Silber et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      One copy of Su(z)25 is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)wm4.

      One copy of Su(z)25 strongly suppresses the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

      (Doheny et al., 2008)

      Su(z)25/+ suppresses the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5, P{hsp26-pt-T}39C-27, P{hsp26-pt-T}39C-31 and P{wA}4-4.

      (Boivin et al., 2003)

      Has little effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males, but acts as a meiotic drive suppressor, suppressing drive against the X and Y chromosomes in these flies.

      (McKee et al., 2000)

      Su(z)25 can show a strong dominant suppression on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w+mW.hs allele at the telomeres of the second and third chromosome. Has no effect on pericentric and fourth chromosome insertions. Su(z)25 suppresses the telomeric Position effect variegation (PEV) of P{hsp26-pt-T}39C-50, P{hsp26-pt-T}39C-58, P{hsp26-pt-T}39C-31, P{hsp26-pt-T}39C-51, P{hsp26-pt-T}39C-62, P{hsp26-pt-T}118E-16, P{hsp26-pt-T}118E-26, P{hsp26-pt-T}118E-21, P{hsp26-pt-T}39C-27 and P{hsp26-pt-T}39C-5.

      (Cryderman et al., 1999)

      No homeotic phenotype. Cannot enhance the homeotic phenotypes of Pc group mutants (FBrf0049524).

      (Cheng et al., 1994)

      In z1 wzm strain mutation causes reduction of eye pigmentation. Slightly suppress w phenotype in a e(y) background.

      (Georgiev, 1994)

      Sensitive to aminopterin.

      (Silber et al., 1993)

      zeste-->yellow-orange eyes

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Su(z)25 is an enhancer of visible phenotype of ctpN2s

      (Melnikova et al., 1996)

      Su(z)25 is an enhancer of visible phenotype of ctn2s

      (Melnikova et al., 1996)
      Suppressor of
      Statement
      Reference

      Su(z)25 is a suppressor of abnormal eye color phenotype of z1

      (Wu et al., 1989)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Su(z)25 is an enhancer of wing phenotype of ctpN2s

      (Melnikova et al., 1996)

      Su(z)25 is an enhancer of wing phenotype of ctn2s

      (Melnikova et al., 1996)
      Suppressor of
      Statement
      Reference

      Su(z)25 is a suppressor of phenotype of z1

      (Wu and Howe, 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of Su(z)25 suppresses the Pairing sensitive silencing effect seen inwMcp.y.scs'.1 and strongly suppresses the eye colour phenotype of double insertion combinations of wMcp.scs'.21/ywe.Mcp.1 (P{Mcp-w#21}124/+, P{Mcp-wy#1}183/+) and wMcp.y.scs'.1/ywe.Mcp.2 (P{Mcp-yw#1}103/+, P{Mcp-wy#2}50/+). The addition of Su(z)25 has no effect on the Pairing sensitive silencing effect seen in wMcp.scs'.21.

      (Muller et al., 1999)

      Has no effect on the phenotypes of ct2s, ct4s and ct6, where the wing margin enhancer is completely blocked.

      (Melnikova et al., 1996)

      Dominant suppressor of z1 eye color: eye color is more wild type. Eye color of heterozygous females which are also z1/z1 : orange (with speckling). Eye color of heterozygous males which are also z1, wis/Y: maroon (with subtle speckling).

      (Wu and Howe, 1995)

      Heterozygous flies modify the yellow eyes of z1 to yellow orange: dominant suppressors of z1 eye colour.

      (Wu et al., 1989)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Wu.

      Comments
      Comments

      Lethal when heterozygous with Psc1.

      (Wu and Howe, 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Su(z)25
      (Doheny et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0013985
      References (19)