FlyBase Allele Report: Dmel\ac[Hw-49c]

General Information

Symbol

Dmel\ac^Hw-49c

Species

D. melanogaster

Name

FlyBase ID

FBal0000172

Feature type

allele

Associated gene

Dmel\ac

Associated Insertion(s)

Carried in Construct

Also Known As

Hw^49c

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

32P

Progenitor genotype

Caused by aberration

In(1)Hw^49c

Cytology

Description

One breakpoint between 14.8 kb and 13.5 kb in the walk of Campuzano et al. (FBrf0042024) and the other between 111 kb and 122 kb in the walk of Chao and Guild.

(Balcells et al., 1988)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

male fertile

viable

(Mazina et al., 1991)

visible | dominant

visible | recessive

(Held, 1990)

Phenotype Manifest In

acrostichal bristle

(Gottlieb, 1964)

anterior sternopleural bristle

(Klein and Campos-Ortega, 1997)

chaeta | ectopic

(Diaz-Benjumea and Garcia-Bellido, 1990)

dorsocentral bristle

macrochaeta

mesothoracic metatarsus

(Held, 1990)

mesothoracic tarsal bristle

(Held, 1990)

microchaeta & mesothoracic tergum | supernumerary

(Renaud and Simpson, 2002)

microchaeta & wing

neuron

(Sturtevant and Bier, 1995)

(Stoddard, 1972)

(Stoddard, 1972)

(Skeath and Carroll, 1991, Gottlieb, 1964)

sensory mother cell & dorsal mesothoracic disc

(Cubas and Modolell, 1992)

sensory mother cell | ectopic

(Cubas and Modolell, 1992)

wing

(Skeath and Carroll, 1991)

wing margin bristle | ectopic

(Badenhorst et al., 2002)

wing vein

(Diaz-Benjumea and Garcia-Bellido, 1990)

wing vein | precursor

(Biehs et al., 1998)

Detailed Description

Statement

Reference

ac^Hw-49c/+ animals exhibit about 60 extra bristles per wing.

(Badenhorst et al., 2002)

ac^Hw-49c animals have a higher density of notal microchaetae, however these bristles still approximately align into rows as seen in wild-type.

(Renaud and Simpson, 2002)

Ectopic neural precursors form along the longitudinal vein primordia.

(Biehs et al., 1998)

Multiple bristles develop instead of a single anterior sternopleural bristle in ac^Hw-49c flies. In ac^Hw-49c; klu^P212 double mutants, no bristles develop in the anterior sternopleural position.

(Klein and Campos-Ortega, 1997)

Grooming behavior normal.

(Phillis et al., 1993)

Two rows of ectopic sensory organ mother cells (SMCs) are seen on the presumptive posterior wing margin in ac^Hw-49c wing imaginal discs. A few extra SMCs also emerge in the dorsocentral notum region during the third larval instar period.

(Cubas and Modolell, 1992)

Ectopic sense organs appear on the notum and wing.

(Skeath and Carroll, 1991)

The total number of bristles on the basitarsi of the second legs is increased. An enlarged bracted bristle is seen near position 5d1 in 22% of cases.

(Held, 1990)

Often lack one or more ocellar or postvertical macrochaetae.

(Stoddard, 1972)

Width of mesonotum in region between dorsocentral bristles increased leading to increased numbers of acrostichal rows as well as extraneous extra microchaetae. Low degree of nonautonomy reported at junction between ac^Hw-49c/ac^Hw-49c and +/+ twin spots.

(Gottlieb, 1964)

Homozygous female has doubling and tripling of many bristles, three or four extra dorsocentral bristles per side, extra wing veins, gap in posterior crossvein and extra hairs on vein L2 and in wing cells. Heterozygous female has normal bristles, extra hairs on L2 and L3 and in wing cells and often an extra free vein from posterior crossvein; also extra acrostichal rows. ac^Hw-49c male much like homozygous female but bristle duplication less extreme. RK1. Not suppressed by su(Hw).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Df(3L)iro-2, ac^Hw-49c, ara¹, caup¹ has visible | recessive phenotype

(Grillenzoni et al., 1998)

Df(3L)iro-2, ac^Hw-49c, ara¹, caup¹ has visible phenotype

(Grillenzoni et al., 1998)

ac^Hw-49c, su(sc)r¹ has visible phenotype

(Georgiev and Gerasimova, 1992)

ac^Hw-49c, su(sc)r¹ has sterile phenotype

(Georgiev and Gerasimova, 1992)

ac^Hw-49c, hry^unspecified, pyd^unspecified has visible | recessive phenotype

(Held, 1990)

Oce^unspecified, ac^Hw-49c has visible phenotype

(Stoddard, 1972)

Phenotype Manifest In

Enhanced by

Statement

Reference

ac^Hw-49c has wing margin bristle | ectopic phenotype, enhanceable by Df(3R)awd-KRB/+

(Badenhorst et al., 2002)

ac^Hw-49c has wing margin bristle | ectopic phenotype, enhanceable by ttk[+]/ttk⁰⁰²¹⁹

(Badenhorst et al., 2002)

ac^Hw-49c has wing margin bristle | ectopic phenotype, enhanceable by ttk[+]/ttk^rM730

(Badenhorst et al., 2002)

Suppressed by

Statement

Reference

ac^Hw-49c has wing margin bristle | ectopic phenotype, suppressible by ttk^69.hs

(Badenhorst et al., 2002)

ac^Hw-49c has phenotype, suppressible by su(sc)r^u1

(Georgiev and Gerasimova, 1992)

ac^Hw-49c has chaeta | ectopic phenotype, suppressible by Egfr^f37

(Diaz-Benjumea and Garcia-Bellido, 1990)

Other

Statement

Reference

Df(3L)iro-2, ac^Hw-49c, ara¹, caup¹ has mesothoracic bristle | lateral phenotype

(Grillenzoni et al., 1998)

ac^Hw-49c, emc¹¹ has dorsal mesothoracic disc & sensory mother cell | ectopic phenotype

(Cubas and Modolell, 1992)

emc¹¹/Df(3L)emc-E12, ac^Hw-49c has dorsal mesothoracic disc & sensory mother cell | ectopic phenotype

(Cubas and Modolell, 1992)

ac^Hw-49c, su(sc)r¹ has wing phenotype

(Georgiev and Gerasimova, 1992)

ac^Hw-49c, hry^unspecified, pyd^unspecified has mesothoracic tarsal bristle phenotype

(Held, 1990)

ac^Hw-49c, hry^unspecified, pyd^unspecified has mesothoracic metatarsus phenotype

(Held, 1990)

Oce^unspecified, ac^Hw-49c has macrochaeta & thorax phenotype

(Stoddard, 1972)

Oce^unspecified, ac^Hw-49c has macrochaeta & head phenotype

(Stoddard, 1972)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of ttk^rM730/+ to ac^Hw-49c/+ animals leads to an 1.35 enhancement of the ectopic wing margin bristle phenotype. The addition of ttk⁰⁰²¹⁹/+ to ac^Hw-49c/+ animals leads to an 1.2 enhancement of the ectopic wing margin bristle phenotype. The addition of Df(3R)awd-KRB/+ to ac^Hw-49c/+ animals leads to an 1.5 enhancement of the ectopic wing margin bristle phenotype. The addition of ttk^69.hs/+ to ac^Hw-49c/+ animals leads slight suppression of the ectopic wing margin bristle phenotype (80% of the bristles seen in ttk^69.hs/+ alone are seen in double mutants..

(Badenhorst et al., 2002)

Bristles of variable size are formed in the otherwise naked lateral region of the notum of ara¹ caup¹/Df(3L)iro-2 flies that are also carrying ac^Hw-49c, at a position corresponding to that of the posterior supraalar bristle. This bristle has a contralateral axon branch in about 70% of cases.

(Grillenzoni et al., 1998)

ac^Hw-49c/+ ; emc¹¹/Df(3L)emc-E12 wing discs have many ectopic SMCs, mostly in the presumptive notum and dorsal wing blade and base.

(Cubas and Modolell, 1992)

Double mutants with su(sc)¹ are sterile and have crumpled wings.

(Georgiev and Gerasimova, 1992)

The extra chaetae found over the wing veins in heterozygous ac^Hw-49c/+ females are removed or reduced in number from the dorsal veins LIII and LV, but not from the LII and LIV ventral veins, by homozygous Egfr^f37 clones in these regions.

(Diaz-Benjumea and Garcia-Bellido, 1990)

h^unspecified pyd^unspecified ac^Hw-49c triple mutants show synergistic increases in the number of bristles on the basitarsi of the second legs.

(Held, 1990)

Acts synergistically with Oce in removing head bristles but cancel each other's effects on thorax in ac^Hw-49c/Oce^unspecified females.

(Stoddard, 1972)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

107676

Notes on Origin

Discoverer

King, 21st March 1949.

Induced with: sc^49c.

Comments

More extreme than ac^Hw-1.

Double mutant ac^Hw-49c, h¹ or ac^Hw-49c, emc^unspecified flies augments the derepression of the achaete-scute complex.

(del Prado and Garcia-Bellido, 1984)

Revertants of ac^Hw-49c lose their dominant phenotypes; however they remain sc and may exhibit a weak ac phenotype or be lethal in combination with Df(1)sc19.

(Garcia Alonso and Garcia-Bellido, 1986)

ac, sc and l(1)sc transcripts considerably more abundant than in wild type; also more generally expressed in wing discs than normal.

(Balcells et al., 1988)

The expression of l(1)sc protein is reduced in mutant embryos.

(Martin-Bermudo et al., 1991)

Overexpression of the ac and sc proteins. The global pattern of h is unchanged but the level of expression is increased.

(Skeath and Carroll, 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hw^49C

(Cubas and Modolell, 1992, Mazina et al., 1991)

Hw^49c

(Aigouy et al., 2004, Renaud and Simpson, 2002, Sato et al., 1999, Biehs et al., 1998, Grillenzoni et al., 1998, Klein and Campos-Ortega, 1997, Phillis et al., 1993, Blair et al., 1992, Martin-Bermudo et al., 1991, Diaz-Benjumea and Garcia-Bellido, 1990, Georgiev, 1990, Held, 1990, Mlodzik et al., 1990, del Prado and Garcia-Bellido, 1984)

ac^Hw-49c

(Levine et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (26)

Report Sections

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