FlyBase Allele Report: Dmel\Egfr[f37]

General Information

Symbol

Dmel\Egfr^f37

Species

D. melanogaster

Name

FlyBase ID

FBal0003565

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

Also Known As

top^4A

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

hypomorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Price et al., 1989)

hypomorphic allele - genetic evidence

(Diaz-Benjumea and Garcia-Bellido, 1990)

Mutagen

gamma ray

(Clifford and Schupbach, 1994)

Progenitor genotype

Cytology

Description

Nucleotide substitution: T2469A. Amino acid replacement: C662S.

(Clifford and Schupbach, 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:21,556,932..21,556,932 [+]

Nucleotide change:

T21556932A

Reported nucleotide change:

T2469A

Amino acid change:

C662S | Egfr-PA; C711S | Egfr-PB

Reported amino acid change:

C662S

(Schupbach, 1999.9.20, Clifford and Schupbach, 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell size | somatic clone

(Diaz-Benjumea and Garcia-Bellido, 1990)

lethal - all die during embryonic stage

(Price et al., 1989)

lethal - all die during embryonic stage | recessive

(Clifford and Schupbach, 1994, Diaz-Benjumea and Garcia-Bellido, 1990)

some die during embryonic stage

(Price et al., 1989)

some die during embryonic stage | recessive

(Clifford and Schupbach, 1994, Diaz-Benjumea and Garcia-Bellido, 1990)

visible | recessive

(Baonza and Garcia-Bellido, 1999, Roch et al., 1998)

Phenotype Manifest In

bract | somatic clone

(del Alamo et al., 2002)

head & macrochaeta | somatic clone

(Diaz-Benjumea and Garcia-Bellido, 1990)

head | somatic clone

(Diaz-Benjumea and Garcia-Bellido, 1990)

leg & macrochaeta | somatic clone

(Diaz-Benjumea and Garcia-Bellido, 1990)

macrochaeta

(Diaz-Benjumea and Hafen, 1994)

macrochaeta | somatic clone

(Diaz-Benjumea and Garcia-Bellido, 1990)

mesothoracic tergum | somatic clone

(Diaz-Benjumea and Garcia-Bellido, 1990)

wing | cell non-autonomous | somatic clone

(Diaz-Benjumea and Garcia-Bellido, 1990)

wing vein

(Clifford and Schupbach, 1994, Diaz-Benjumea and Hafen, 1994)

wing vein | cell autonomous | somatic clone

(Diaz-Benjumea and Garcia-Bellido, 1990)

wing vein | ectopic

(Diaz-Benjumea and Hafen, 1994)

wing vein L4

(Baonza and Garcia-Bellido, 1999, Roch et al., 1998)

Detailed Description

Statement

Reference

Homozygous somatic clones in the legs and wings have bractless mechanosensory bristles.

(del Alamo et al., 2002)

Egfr^t1/Egfr^f37 flies show loss of wing vein L4.

(Baonza and Garcia-Bellido, 1999)

Egfr^f37/Egfr^t1 lack wing vein L4. Wing clones of Egfr^f37 mutant cells are smaller, narrower amd more elongated than controls and are incapable of differentiating vein histotype except in L1.

(Roch et al., 1998)

In trans to Egfr^t1, Egfr^f37 shows unexpectedly severe wing vein abnormalities.

(Clifford and Schupbach, 1994)

Clonal analysis reveals phenotypes in the adult including loss of wing vein, ectopic wing vein, reduced cell size, extra bristles, cell lethality and tergite bristle abnormalities. Phenotype is cell autonomous. rl¹/Df(2R)rl10a strongly enhances the wing phenotype of Egfr^t1/Egfr^f37.

(Diaz-Benjumea and Hafen, 1994)

Strong hypomorph. The viability of homozygous clones in the wing is reduced, but higher than the viability of homozygous Egfr^f24 or Egfr^f11 clones in the wing. Cells in the Egfr^f37 clone are 40-50% smaller than normal. A clone present on one wing surface causes the opposite wing surface to blister. Wing veins fail to differentiate where clones cross them, although the sensilla campaniformia of wing vein LIII are not removed by dorsal clones crossing this vein. The failure to differentiate wing vein is cell autonomous. Wild-type cells may differentiate into extra wing vein material abutting the clone border when the border is near the normal course of a vein. Homozygous clones in the notum contain small cells, with densely packed trichomes. Cell density is 40-50% higher than normal. Clones in the leg contain extra chaetae. Clones in the head contain small cells, with extra chaetae. Homozygous clones in the abdominal tergites are viable.

(Diaz-Benjumea and Garcia-Bellido, 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Egfr^f37/Egfr^t1 has visible phenotype, enhanceable by emc^D

(Baonza and Garcia-Bellido, 1999)

Suppressed by

Statement

Reference

Egfr^f37/Egfr^t1 has visible phenotype, suppressible by emc¹/emc¹¹

(Baonza and Garcia-Bellido, 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Egfr^f37/Egfr^t1 has wing vein phenotype, enhanceable by emc^D

(Baonza and Garcia-Bellido, 1999)

Suppressed by

Statement

Reference

Egfr^f37/Egfr^t1 has wing vein L4 phenotype, suppressible by emc¹/emc¹¹

(Baonza and Garcia-Bellido, 1999)

Egfr^f37 has phenotype, suppressible by bs⁰³²⁶⁷

(Roch et al., 1998)

Suppressor of

Statement

Reference

Egfr^f37 is a suppressor of chaeta | ectopic phenotype of ac^Hw-49c

(Diaz-Benjumea and Garcia-Bellido, 1990)

Other

Statement

Reference

Egfr^f37/Egfr^t1, vvl^sep has wing vein L2 phenotype

(de Celis et al., 1995)

Egfr^f37/Egfr^t1, vvl^sep has wing vein L3 phenotype

(de Celis et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

This loss of wing vein L4 seen in Egfr^t1/Egfr^f37 flies is suppressed by emc¹/emc¹¹. emc^D enhances the loss of wing veins seen in Egfr^t1/Egfr^f37 flies.

(Baonza and Garcia-Bellido, 1999)

Double mutant wing clones with Egfr^f37 occupy vein territories like those for bs⁰³²⁶⁷ but with a frequency and size similar to Egfr^f37 controls. Double mutant cells differentiate autonomously into pigmented, corrugated and compacted cells characteristic of the vein histotype.

(Roch et al., 1998)

The extra chaetae found over the wing veins in heterozygous ac^Hw-49c/+ females are removed or reduced in number from the dorsal veins LIII and LV, but not from the LII and LIV ventral veins, by homozygous Egfr^f37 clones in these regions.

(Diaz-Benjumea and Garcia-Bellido, 1990)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: Failure to complement the wing-vein defect of "Egfr^t" alleles.

Comments

Class IV allele.

(Clifford and Schupbach, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

DER^top4A

(Diaz-Benjumea and Hafen, 1994)

EGFr^4A

(del Alamo et al., 2002)

Egfr^f37

flb

top^4A

(del Alamo et al., 2002, Baonza and Garcia-Bellido, 1999, Roch et al., 1998, de Celis et al., 1995, Clifford and Schupbach, 1994, de Celis and Garcia-Bellido, 1994, Diaz-Benjumea and Garcia-Bellido, 1990, Price et al., 1989)

top^4a

(Galindo et al., 2005)

Name Synonyms

faint little ball

Secondary FlyBase IDs

References (11)

Report Sections

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