FlyBase Allele Report: Dmel\abd-A[M1]

Postembryonic neuroblast clones in the anterior and posterior thorax which are mutant for abd-A^M1 are normal in size. Postembryonic neuroblasts (pNBs) in the central abdomen which are mutant for abd-A^M1 produce abnormally large clones in larvae. The pNB in the clone survives past 72 hours after larval hatching and can often be seen expressing phosphorylated His3 protein at 96 hours after larval hatching. No more than two phosphorylated His3-positive cells per clone are found at any one time, corresponding to the pNB and one ganglion mother cell.

(Bello et al., 2003)

Late homozygous embryos have abnormal oenocyte clusters.

(Brodu et al., 2002)

No gross morphological defects are seen in the central nervous system of homozygous embryos.

(Hirth et al., 1998)

Dissected guts from freshly hatched larvae do not have any copper cells. P{HS-wg} function without heat induction is sufficient to allow some copper cell formation, mild heat induction produces large numbers of cells. As expected after severe heat treatment no copper cells could be discerned, or interstitial cells but large numbers of large flat cells could be seen.

(Hoppler and Bienz, 1995)

Ubx^MX12 abd-A^M1 Abd-B^M8 triple mutant embryos exhibit a normal head and anterior thorax, but the third thoracic segment and all the abdominal segments are transformed into the second thoracic segment. Embryos also develop a pair of sclerotic plates in the posterior part of the A8 segment. Heat activation of abd-A^hs.PS transforms the cephalic, thoracic and first abdominal segment into A2-A6 identity. The posterior abdomen exhibits transformation of A8 to the A2-A6 identity and presence of an extra belt in A9.

(Sanchez-Herrero et al., 1994)

Antibody staining revealed that abd-A^M1 is required for lch5 in A1-A7 and contributes to es and ch organs in A2-A7.

(Heuer and Kaufman, 1992)

First instar larvae exhibit lateral dots (a paired structure found in A1 segment of wild type) in abdominal segment A2 and rarely in A3 to A5.

(Jijakli and Ghysen, 1992)

lab expression in midgut (as indicated by lab-lacZ fusion genes) extended posteriorly.

(Tremml and Bienz, 1992)

The second thoracic to the seventh abdominal segment develop as a composite of compartments from two segments. The identity of the eighth abdominal segment is complex: the anterior has characteristics of prothoracic and mesothoracic segments and the posterior may be cephalic. abd-A^- embryos have an abnormal pattern of Dll expression at the extended germ band stage: Keilin's organs develop in the abdominal segments due to ectopic expression of Dll.

(Simcox et al., 1991)

Hemizygous embryonic phenotype displays complete transformation of abdominal parasegments 7, 8 and 9 into parasegment 6 and partial transformation of abdominal parasegments 10 to 13 into parasegment 6 (FBrf0043314).

(Busturia et al., 1989)

Only the first of the three midgut constrictions forms properly in mutant embryos.

(Bienz and Tremml, 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Ubx^MX6, abd-A^M1 has abnormal neuroanatomy | first instar larval stage phenotype

(Estacio-Gómez et al., 2013)

Phenotype Manifest In

Suppressed by

Statement

Reference

abd-A^M1 has embryonic/larval oenocyte phenotype, suppressible by Scer\GAL4^salm-459.2/btl::Egfr^λ.UAS

(Brodu et al., 2002)

abd-A^M1 has embryonic/larval oenocyte phenotype, suppressible by spi^s.UAS/Scer\GAL4^ato.3.6

(Brodu et al., 2002)

abd-A^M1 has embryonic/larval oenocyte phenotype, suppressible by Scer\GAL4^en-e16E/spi^s.UAS

(Brodu et al., 2002)

Abd-B^M8, Antp^Ns-rvC3, Scr^C1, Ubx^MX2, abd-A^M1 has embryonic epidermis phenotype, suppressible by Dfd^hs.PK

(Macias and Morata, 1996)

Abd-B^M8, Antp^Ns-rvC3, Scr^C1, Ubx^MX2, abd-A^M1 has embryonic epidermis phenotype, suppressible by lab^hs.PH

(Macias and Morata, 1996)

Abd-B^M8, Antp^Ns-rvC3, Scr^C1, Ubx^MX2, abd-A^M1 has embryonic epidermis phenotype, suppressible by Ubx^hs.PG

(Macias and Morata, 1996)

Suppressor of

Statement

Reference

abd-A^M1/abd-A^M1 is a suppressor | partially of embryonic/larval oenocyte | increased number phenotype of Egfr^act.B.UAS, Scer\GAL4^en-e16E

(Brodu et al., 2004)

Other

Statement

Reference

Ubx^MX6, abd-A^M1 has larval ventral nerve cord | first instar larval stage phenotype

(Estacio-Gómez et al., 2013)

Ubx^MX6, abd-A^M1 has larval abdominal ganglion Leucokinin neuron | first instar larval stage | absent phenotype

(Estacio-Gómez et al., 2013)

Abd-B^M8, Antp^Ns-rvC3, Scr^C1, abd-A^M1, hth^C1 has embryonic abdominal segment phenotype

(Rieckhof et al., 1997)

Abd-B^M8, Antp^Ns-rvC3, Scr^C1, abd-A^M1 has embryonic abdominal segment phenotype

(Rieckhof et al., 1997)

Abd-B^M8, Antp^Ns-rvC3, Scr^C1, Ubx^MX2, abd-A^M1 has embryonic epidermis phenotype

(Macias and Morata, 1996)

Abd-B^S10, abd-A^M1 has abdominal segment 7 phenotype

(Hendrickson and Sakonju, 1995)

Abd-B^S10, abd-A^M1 has abdominal segment 5 phenotype

(Hendrickson and Sakonju, 1995)

Abd-B^S10, abd-A^M1 has abdominal segment 6 phenotype

(Hendrickson and Sakonju, 1995)

Additional Comments

Genetic Interactions

Statement

Reference

In stage 16 Egfr^{act.B.Scer\UAS}; Scer\GAL4^en-e16E embryos, there are increased numbers of oenocytes per cluster. The number of oenocytes per cluster follows a multi-modal distribution, with peaks corresponding to multiples of 3 (12, 15, 18 and 21) suggesting that additional rounds of delamination, generally of 3 oeoncytes per round as in wild-type, are occurring. This multi-modal distribution and increased numbers of per cluster are partially suppressed by abd-A^M1/abd-A^M1.

(Brodu et al., 2004)

Postembryonic neuroblast clones in the anterior or posterior thorax which are mutant for both abd-A^M1 Ubx^MX6 are normal in size.

(Bello et al., 2003)

Expression of spi^s.Scer\UAS under the control of Scer\GAL4^en-e16E or Scer\GAL4^ato.3.6 rescues the formation of oenocytes in abd-A^M1 mutant embryos. Expression of btl::Egfr^{Scer\UAS.T:λ\cI-DD} under the control of Scer\GAL4^salm-459.2 completely rescues the formation of oenocytes in abd-A^M1 mutant embryos.

(Brodu et al., 2002)

Antp^Ns-rvC3 Scr^C1 abd-A^M1 Abd-B^M8 quadruple mutant embryos secrete cuticle which has a reiteration of the A1 segment throughout the abdomen. If these embryos are also mutant for hth^C1 the abdominal segments all resemble the third abdominal segment.

(Rieckhof et al., 1997)

Quintuple Scr^C1, Antp^Ns-rvC3, Ubx^MX2, abd-A^M1, Abd-B^M8 homozygous larvae (deficient for activity of thoracic and abdominal homeotic genes) exhibit sclerotic plates (sp) anterior to each denticle belt. Expression of Dfd^hs.PK, lab^hs.PH or Ubx^hs.PG suppresses the differentiation of the sp.

(Macias and Morata, 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Morata.

Comments

wg expression is absent in abd-A^M1 homozygotes.

(Immergluck et al., 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Abd-A^M1

(Uhl et al., 2016)

AbdAM1

(Zmojdzian et al., 2018)

abd-A^M1

(Requena et al., 2017, Moris-Sanz et al., 2015, Pinto et al., 2015, Garaulet et al., 2014, Li-Kroeger et al., 2012, Li-Kroeger et al., 2008, Scuderi et al., 2006, Brodu et al., 2004)

abd-A^m1

(Mukai et al., 1999)

abdA^M1

(Roumengous et al., 2017, Banreti et al., 2014, Estacio-Gómez et al., 2013, Witt et al., 2010, Perrin et al., 2004, Riede, 2004, Bello et al., 2003, Brodu et al., 2002, Azpiazu and Morata, 1998, Fuss and Hoch, 1998, Chan and Mann, 1993)

abdA^m1

(Grieder et al., 1997)

abda^m1

(Zandvakili et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (70)

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