FlyBase Allele Report: Dmel\Scr[C1]

General Information

Symbol

Dmel\Scr^C1

Species

D. melanogaster

Name

FlyBase ID

FBal0030204

Feature type

allele

Associated gene

Dmel\Scr

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Bachiller et al., 1994, Gonzalez-Reyes and Morata, 1991)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

antenna | ectopic | somatic clone

(Struhl, 1982)

haltere | somatic clone

(Struhl, 1982)

labellum | somatic clone

(Struhl, 1982)

maxillary palp | ectopic | somatic clone

(Struhl, 1982)

mesothoracic leg | somatic clone

(Struhl, 1982)

metathoracic laterotergite | somatic clone

(Struhl, 1982)

metathoracic leg | somatic clone

(Struhl, 1982)

prothoracic leg | somatic clone

(Struhl, 1982)

scutum | ectopic | somatic clone

(Struhl, 1982)

wing | ectopic | somatic clone

(Struhl, 1982)

Detailed Description

Statement

Reference

In Ubx^hs.PG embryos that are homozygous for Scr^C1 the labial sense organ is missing, and there is a duplication of the maxillary sense organ.

(Gonzalez-Reyes and Morata, 1991)

The phenotype of triply mutant clones Antp^Ns-rvC3 Scr^C1 Ubx¹ induced at the blastoderm stage or larval stage is the additive phenotype of Antp^Ns-rvC3 and Scr^13A Ubx¹ clones, portions of all three legs are transformed to antennae, clones in the haltere and metanotum form wing and mesonotum structures and transformation of labial palps of the proboscis into maxillary palps. The phenotype of Antp^Ns-rvC3 Scr^C1 clones induced in the head, pro- and mesothorax during embryonic and larval development are indistinguishable from Antp^Ns-rvC3 Scr^C1 Ubx¹ clones.

(Struhl, 1982)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has abnormal neuroanatomy | somatic clone phenotype

(Parrish et al., 2007)

Antp^Ns-rvC3, Scr^C1, hth^Meis1-P2 has visible | somatic clone phenotype

(Casares and Mann, 2001)

Phenotype Manifest In

Suppressed by

Statement

Reference

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has motor neuron | somatic clone | third instar larval stage phenotype, suppressible by Scer\GAL4^VGlut-OK371/Scer\GAL4^Tub.PU/BacA\p35^UAS.cHa

(Baek et al., 2013)

Abd-B^M8, Antp^Ns-rvC3, Scr^C1, Ubx^MX2, abd-A^M1 has embryonic epidermis phenotype, suppressible by Dfd^hs.PK

(Macias and Morata, 1996)

Abd-B^M8, Antp^Ns-rvC3, Scr^C1, Ubx^MX2, abd-A^M1 has embryonic epidermis phenotype, suppressible by lab^hs.PH

(Macias and Morata, 1996)

Abd-B^M8, Antp^Ns-rvC3, Scr^C1, Ubx^MX2, abd-A^M1 has embryonic epidermis phenotype, suppressible by Ubx^hs.PG

(Macias and Morata, 1996)

NOT suppressed by

Statement

Reference

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has glial cell | third instar larval stage phenotype, non-suppressible by Scer\GAL4^VGlut-OK371/Scer\GAL4^Tub.PU/BacA\p35^UAS.cHa

(Baek et al., 2013)

Other

Statement

Reference

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has motor neuron | somatic clone | third instar larval stage phenotype

(Baek et al., 2013)

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has glial cell | third instar larval stage phenotype

(Baek et al., 2013)

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has motor neuron | somatic clone | adult stage phenotype

(Baek et al., 2013)

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has dendrite & dorsal multidendritic neuron ddaC | somatic clone phenotype

(Parrish et al., 2007)

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has dendrite & dendritic arborising neuron | somatic clone phenotype

(Parrish et al., 2007)

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has axon & dendritic arborising neuron | somatic clone phenotype

(Parrish et al., 2007)

Antp^Ns-rvC3, Scr^C1 has embryonic epidermis phenotype

(Mace et al., 2005)

Antp^Ns-rvC3, Scr^C1, hth^Meis1-P2 has prothoracic leg | somatic clone phenotype

(Casares and Mann, 2001)

Antp^Ns-rvC3, Scr^C1, hth^Meis1-P2 has mesothoracic leg | somatic clone phenotype

(Casares and Mann, 2001)

Abd-B^M8, Antp^Ns-rvC3, Scr^C1, abd-A^M1, hth^C1 has embryonic abdominal segment phenotype

(Rieckhof et al., 1997)

Abd-B^M8, Antp^Ns-rvC3, Scr^C1, abd-A^M1 has embryonic abdominal segment phenotype

(Rieckhof et al., 1997)

Abd-B^M8, Antp^Ns-rvC3, Scr^C1, Ubx^MX2, abd-A^M1 has embryonic epidermis phenotype

(Macias and Morata, 1996)

Additional Comments

Genetic Interactions

Statement

Reference

The number of LinA-derived neurons is dramatically reduced compared to wild type in Scr^C1 Antp^Ns-rvC3 Ubx^MX12 triple mutant clones examined at the late third instar larval stage. This phenotype is seen in all three thoracic segments. The number of glia derived from the triple mutant LinA neuroblast clones is also reduced compared to wild type.

Adult motor neurons derived from Scr^C1 Antp^Ns-rvC3 Ubx^MX12 triple mutant LinA neuroblast clones target the same region of the leg as do wild-type LinA-derived neurons. However, fewer branches are observed compared with wild-type clones, with the distal region of the tibia being most highly affected.

(Baek et al., 2013)

Single cell class IV dendrite arborisation (da) neuron clones that are triply mutant for Scr^C1, Antp^Ns-rvC3, Ubx^MX12 show severe defects in dendrite growth, branching and coverage in segment T3 as well as axon fasciculation defects. Analysis of Scr^C1, Antp^Ns-rvC3, Ubx^MX12 triple mutant ddaC neuron clones indicates that although the major dendrites of the mutant neurons grow to a similar extent as wild-type controls in the interval between 80 and 96 hours after egg laying, the mutant clones have an increased number of terminal dendrites compared to controls. The mutant clones also show increased dynamic behaviour over this time period compared to controls, due to increased dendrite branch initiation/growth. The number of dendrite retractions is not altered in the mutant neurons.

(Parrish et al., 2007)

Scr^C1 Antp^Ns-rvC3 double mutant embryos develop ectopic sclerites, which often look like the cuticular scar tissue that often surrounds the healed wound generated by a sterile needle in late-stage wild-type embryos.

Scr^C1 Antp^Ns-rvC3 double mutant stage 17 embryos have failures in epidermal integrity; dye injected into the perivitelline space penetrates the body cavity in the mutant embryos.

(Mace et al., 2005)

Antp^Ns-rvC3 hth^Meis1-P2 Scr^C1 triple mutant clones result in two-segment appendages in T1 and T2.

(Casares and Mann, 2001)

Antp^Ns-rvC3 Scr^C1 abd-A^M1 Abd-B^M8 quadruple mutant embryos secrete cuticle which has a reiteration of the A1 segment throughout the abdomen. If these embryos are also mutant for hth^C1 the abdominal segments all resemble the third abdominal segment.

(Rieckhof et al., 1997)

Quintuple Scr^C1, Antp^Ns-rvC3, Ubx^MX2, abd-A^M1, Abd-B^M8 homozygous larvae (deficient for activity of thoracic and abdominal homeotic genes) exhibit sclerotic plates (sp) anterior to each denticle belt. Expression of Dfd^hs.PK, lab^hs.PH or Ubx^hs.PG suppresses the differentiation of the sp.

(Macias and Morata, 1996)

Xenogenetic Interactions

Statement

Reference

Expression of BacA\p35^Scer\UAS.cHa under the simultaneous control of both Scer\GAL4^VGlut-OK371 and Scer\GAL4^tub.PU rescues the reduced number of LinA-derived neurons seen in Scr^C1 Antp^Ns-rvC3 Ubx^MX12 triple mutant clones examined at the late third instar larval stage. The reduction in number of glia derived from the triple mutant LinA neuroblast clones is not rescued.

Expression of BacA\p35^Scer\UAS.cHa under the simultaneous control of both Scer\GAL4^VGlut-OK371 and Scer\GAL4^tub.PU partially rescues the defects seen in adult motor neurons of the leg derived from Scr^C1 Antp^Ns-rvC3 Ubx^MX12 triple mutant LinA neuroblast clones.

(Baek et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Scr^C1

(Sánchez-Higueras et al., 2019, Banreti et al., 2014, Baek et al., 2013, Parrish et al., 2007, Mace et al., 2005)

Scr^c1

(Chan and Mann, 1993)

Name Synonyms

Secondary FlyBase IDs

References (21)

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