Liu, X., Yu, Q.A., Huang, Z.S., Zwiebel, L.J., Hall, J.C., Rosbash, M. (1991). The strength and periodicity of Drosophila melanogaster circadian rhythms are differentially affected by alterations in period gene expression.  Neuron 6(): 753--766.

FBrf0054815

Research paper

The per gene of D. melanogaster influences or participates in the generation of biological rhythms. Previous experiments have identified the head as the location from which per exerts its effect on circadian rhythms. To localize further this region and to examine the effects of altered levels and altered spatial expression patterns of the per gene on circadian rhythms of locomotor activity, we have characterized transformed lines containing per gene constructs missing substantial cis-acting regulatory information. The data suggest that wild-type levels of per gene expression are necessary in only a small fraction of the nervous system for near wild-type periods, whereas a larger fraction of per-expressing cells in the brain contributes to the strength of the circadian rhythms.