mtv, bks, brakeless, master of thickveins, l(2)04440
novel protein with a single zinc finger - multifunctional protein that regulates foraging activity and shapes the activity gradient of Dpp through regulation of thickveins - regulates transcription by interacting with Mediator complex subunit Med19
Please see the JBrowse view of Dmel\sbb for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.39
Stop-codon suppression (UGA) postulated; FBrf0216884
Gene model reviewed during 5.44
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.50
10.5, 7.8, 3.6, 1.6 (northern blot)
929 (aa); 80 (kD observed); 88 (kD predicted)
2302, 929 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sbb using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
sbb transcripts are ubiquitously distributed in early embryos. After gastrulation, transcripts are observed in the developing central nervous system. Both major transcript types are observed in early embryose by RT-PCR.
JBrowse - Visual display of RNA-Seq signals
View Dmel\sbb in JBrowse2-85
2-89.4
2-83
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
DNA-protein interactions: genome-wide binding profile assayed for sbb protein in 0-12 hr embryos; see mE1_TFBS_sbb collection report.
Mutant clones cause pattern defects in the adult wing, such as ectopic venation and transformation of bristle types.
sbb is essential for R1-R6 growth cone targeting.
sbb is required in the developing eye specifically for the lamina targeting of R1-R6 photoreceptor cell axons.
Larvae with mutations in sbb show abnormally high amounts of turning behaviour in the absence of food.
Mutant males court females and generate courtship songs with the normal pattern and yet are unsuccessful in copulation.
Source for merge of: sbb mtv
Source for merge of: sbb brakeless
Source for merge of: sbb plt
Source for merge of sbb brakeless was sequence comparison ( date:000519 ).
Source for merge of sbb mtv was sequence comparison ( date:010111 ).
Source for identity of brakeless CG5580 was sequence comparison ( date:000504 ).
Source for identity of: brakeless CG5580
Source for identity of: sbb bks
Source for identity of: sbb bks mtv
Mutant R1-R6 photoreceptor axons fail to stop in the lamina, which inspired the name "brakeless" (Y. Rao and S.L. Zipursky, personal communication).
Name reflects pattern of larval trail on agar plate.
