FlyBase Gene Report: Dmel\SNRPG

General Information

Symbol

Dmel\SNRPG

Species

D. melanogaster

Name

Small nuclear ribonucleoprotein G

Annotation Symbol

CG9742

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261791

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Small nuclear ribonucleoprotein G (SNRPG) encodes a Sm class protein and a common component of pre-mRNA processing U snRNPs. It forms the toroidal core of U snRNPs (Sm core domain) together with 6 related Sm proteins. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

SmG, snRNPG

Key Links

Genomic Location

Cytogenetic map

14F4-14F4

Sequence location

X:16,639,810..16,640,419 [-]

Recombination map

1-54

RefSeq locus

NC_004354 REGION:16639810..16640419

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (17 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

contributes_to RNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000058283

(GO Reference Genome Project, 2011-)

enables RNA binding

inferred from electronic annotation with InterPro:IPR047575

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with HGNC:11163

(Gene Ontology Curators, 2002-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in mRNA splicing, via spliceosome

inferred by curator from GO:0071011,GO:0071013

(Herold et al., 2009)

inferred from biological aspect of ancestor with PANTHER:PTN000058285

(GO Reference Genome Project, 2011-)

involved_in spliceosomal snRNP assembly

inferred from electronic annotation with InterPro:IPR034098

(InterPro Project Members, 2004-)

Cellular Component (14 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

located_in nucleus

inferred from direct assay

(Paterson et al., 1991)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

part_of small nuclear ribonucleoprotein complex

inferred from direct assay

(Paterson et al., 1991)

Terms Based on Predictions or Assertions (13 terms)

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from biological aspect of ancestor with PANTHER:PTN000058284

(GO Reference Genome Project, 2011-)

is_active_in P granule

inferred from biological aspect of ancestor with PANTHER:PTN000058285

(GO Reference Genome Project, 2011-)

part_of precatalytic spliceosome

inferred from biological aspect of ancestor with PANTHER:PTN000058285

(GO Reference Genome Project, 2011-)

part_of small nuclear ribonucleoprotein complex

inferred from sequence or structural similarity with SGD:S000002965

(Mount and Salz, 2000)

part_of SMN-Sm protein complex

inferred from biological aspect of ancestor with PANTHER:PTN000058285

(GO Reference Genome Project, 2011-)

part_of spliceosomal complex

inferred from sequence or structural similarity with SGD:S000002965

(Mount and Salz, 2000)

inferred from electronic annotation with InterPro:IPR034098

(InterPro Project Members, 2004-)

part_of spliceosomal tri-snRNP complex

inferred from biological aspect of ancestor with PANTHER:PTN000058285

(GO Reference Genome Project, 2011-)

part_of U1 snRNP

inferred from biological aspect of ancestor with PANTHER:PTN000058285

(GO Reference Genome Project, 2011-)

part_of U12-type spliceosomal complex

inferred from biological aspect of ancestor with PANTHER:PTN000058284

(GO Reference Genome Project, 2011-)

part_of U2 snRNP

inferred from biological aspect of ancestor with PANTHER:PTN000058285

(GO Reference Genome Project, 2011-)

part_of U2-type prespliceosome

inferred from biological aspect of ancestor with PANTHER:PTN000058284

(GO Reference Genome Project, 2011-)

part_of U4 snRNP

inferred from biological aspect of ancestor with PANTHER:PTN000058285

(GO Reference Genome Project, 2011-)

part_of U5 snRNP

inferred from biological aspect of ancestor with PANTHER:PTN000058285

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

U1 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE

U2 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE

U5 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE

U4-U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE

U4-U6-U5 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE

SPLICEOSOMAL SM PROTEINS

SPLICEOSOME COMPLEX A

SPLICEOSOME COMPLEX B

SPLICEOSOME COMPLEX C

SPLICEOSOME COMPLEX P

U7 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE

U7 SM PROTEINS

Protein Family (UniProt)

Belongs to the snRNP Sm proteins family. (Q9VXE0)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

U1 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -: The U1 small nuclear ribonucleoprotein particle (U1 snRNP) contains U1 snRNA and initiates spliceosome assembly by binding to the 5' splice site in pre-mRNA. (Adapted from PMID:11206553 and PMID:21441581).
U2 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -: The U2 small nuclear ribonucleoprotein particle (U2 snRNP) contains U2 snRNA. It is recruited to the spliceosome after U1 snRNP and forms a stable interaction with the branch site and 3' splice site in pre-mRNA. (Adapted from PMID:23829528 and PMID:21441581).
U5 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -: The U5 small nuclear ribonucleoprotein particle (U5 snRNP) contains U5 RNA and assembles with U4-U6 snRNP to form the U4-U6.U5 tri-snRNP. U5 snRNA interacts with the 5' and 3' exons. (Adapted from PMID:21441581).
U4-U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -: The U4/U6 small nuclear ribonucleoprotein particle (U4/U6 snRNP) is a complex that contains base-paired U4 and U6 snRNAs. U4/U6 snRNP assembles with U5 to form the U4/U6.U5 tri-snRNP. (Adapted from PMID:21441581).
U4-U6-U5 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -: U4/U6.U5 tri-snRNP is assembled from U5 and U4/U6 snRNPs. The complex contains U4 and U6 snRNAs base-paired with each other and U6 snRNA. This complex is recruited to the pre-catalytic splicing intermediate, complex B. (Adapted from PMID:21441581).
SPLICEOSOMAL SM PROTEINS -: The spliceosomal Sm proteins are common to all spliceosomal small nuclear ribonucleoproteins (snRNPs). Sm proteins assemble in a stepwise manner onto the Sm site element of the U1, U2, U4 and U5 spliceosomal snRNAs forming a ring-shaped core RNP structure. (Adapted from PMID:11226169).
SPLICEOSOME COMPLEX A -: Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex A, the pre-spliceosome, is composed of U1 and U2 snRNPs and proteins involved in recognition of the 5' splice site and branch point. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX B -: Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. After the assembly of complex A on pre-mRNA, the U4-U6 and U5 snRNPs are recruited as a preassembled tri-snRNP to form complex B. U5 snRNP binds exons at the 5' site. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX C -: Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex B undergoes a number of structural rearrangements and U4 and U1 snRNPs dissociate to generate complex C, the catalytic spliceosome. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX P -: Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex P, the post-spliceosomal complex, is formed after the catalytic removal of the intron by complex C. Complex P contains the lariat intron and spliced exons. (Adapted from PMID:24452469 and PMID:23118483).
U7 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -: The U7 snRNP involved in histone pre-mRNA 3' end processing consists of two core components: an U7 snRNA and an unusual heptameric Sm ring. (Adapted from FBrf0168021 and FBrf0208608).
U7 SM PROTEINS -: The U7 snRNP is involved in histone mRNA 3' end processing. Sm proteins are common to all small nuclear ribonucleoproteins (snRNPs), assembling in a stepwise manner onto snRNAs, forming a ring-shaped core RNP structure. (Adapted from FBrf0168021 and FBrf0208608).

Protein Function (UniProtKB)

Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:18621711). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome (By similarity).

(UniProt, Q9VXE0)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\SNRPG for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VXE0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0074377

483

FBtr0112993

432

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

SNRPG-PA

FBpp0074151

8.5

9.27

FBpp0111906

8.5

9.27

Q9VXE0

NP_001138209

ACL82939

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

76 aa isoforms: SNRPG-PA, SNRPG-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with the SMN complex (PubMed:18621711). Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. Component of the U4/U6-U5 tri-snRNP complex. Component of the U7 snRNP complex. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (By similarity).

(UniProt, Q9VXE0)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VXE0

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SNRPG using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

SmG_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.59

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

located_in nucleus

inferred from direct assay

(Paterson et al., 1991)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

part_of small nuclear ribonucleoprotein complex

inferred from direct assay

(Paterson et al., 1991)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SNRPG in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\SNRPG

View exonic expression by tissue for Dmel\SNRPG

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261791

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32636/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261791

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030765

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261791

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9742

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of SNRPG

Transgenic constructs containing regulatory region of SNRPG

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)YO17

(Manning et al., 2013)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

SNRPG^GD15460

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

SNRPG^GD15460

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

SNRPG^GD15460

viable, with Scer\GAL4^tin.CΔ4

SNRPG^GD15460

Other Phenotypes

Allele

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

SNRPG^GD15460

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

SNRPG^GD15460

Phenotype manifest in

Allele

retina, with Scer\GAL4^GMR.PU

SNRPG^HMS04502

sarcomere, with Scer\GAL4^Mef2.PR

SNRPG^GD15460

Z disc, with Scer\GAL4^Mef2.PR

SNRPG^GD15460

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (17)

Hsap\SNRPG

14 of 14

Yes

Hsap\SNRPGP15

9 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (21)

Rnor\LOC687679

13 of 14

Yes

Rnor\Snrpg

12 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Snrpn

1 of 14

Rnor\Zfp341

1 of 14

Yes

Mus musculus (laboratory mouse) (15)

Mmus\Snrpg

12 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (10)

Xtro\snrpg

11 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (13)

Drer\snrpg

13 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\snr-7

13 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (15)

Agam\AgaP_AGAP002706

12 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (22)

Atha\AT3G11500

12 of 13

Yes

Atha\SNRNP-G

12 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (14)

Scer\SMX2

11 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (14)

Spom\smg1

11 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:SNRPG. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (13)

4 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

SmB

1 of 13

SmD2

1 of 13

SmE

1 of 13

SmF

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SNRPG; small nuclear ribonucleoprotein polypeptide G

14 of 14

603542

SNRPGP15; small nuclear ribonucleoprotein polypeptide G pseudogene 15

9 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

SNRPG - Sf3b5

anti tag coimmunoprecipitation, peptide massfingerprinting

(Stegeman et al., 2016)

SNRPG - SmD2

experimental knowledge based

(Guruharsha et al., 2011)

SNRPG - SmE

molecular sieving, molecular weight estimation by staining

(Chari et al., 2008)

SNRPG - SmF

molecular sieving, molecular weight estimation by staining

(Chari et al., 2008)

SNRPG - Smn

molecular sieving, molecular weight estimation by staining

(Chari et al., 2008)

SNRPG - icln

molecular sieving, molecular weight estimation by staining

(Chari et al., 2008)

SNRPG - snf

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Stegeman et al., 2016, Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

(UniProt, Q9VXE0 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261791

MIST (protein-protein) - An integrated Molecular Interaction Database

32636

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Spliceosome

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-54

Cytogenetic map

14F4-14F4

Sequence location

X:16,639,810..16,640,419 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

14F4-14F4

Limits computationally determined from genome sequence between P{EP}EP1547^EP1547 and P{EP}CG4928^EP1341

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-54

(FlyBase, 2016)

1-55.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

26617

w^* P{EP}SNRPG^G1189/FM6, w^*

FlyORF

F001307

M{UAS-SNRPG.ORF}ZH-86Fb

F001160

M{UAS-SNRPG.ORF.3xHA}ZH-86Fb

VDRC

v39255

w¹¹¹⁸; P{GD15460}v39255

v39256

w¹¹¹⁸; P{GD15460}v39256

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (80)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_RE61341

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261791

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

GM18092

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261791

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

RNAi screen using dsRNA made from templates generated with primers directed against this gene results in a long metaphase spindle with misaligned chromosomes when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

(Goshima et al., 2007)

Identified as a protein which is common to all small nuclear ribonucleoprotein particles (snRNPs).

(Paterson et al., 1991)

Relationship to Other Genes

Source for database merge of

Source for merge of: SmG snRNPG

(Labourier and Rio, 2001)

Source for merge of: CG9742 BcDNA:RH35475

(FlyBase, 1996-)

Source for merge of: CG9742 BcDNA:RE61341

(FlyBase, 1996-)

Additional comments

Source for merge of CG9742 BcDNA:RH35475 was TrEMBL update ( date:020807 ).

(FlyBase, 1996-)

Source for merge of CG9742 BcDNA:RE61341 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: SmG CG9742

(Goshima et al., 2007)

Source for identity of: SNRPG SmG

(FlyBase, 2009-)

Nomenclature comments

The gene symbol "SmG" has been changed to "SNRPG" (a synonym, and the HGNC symbol of the human ortholog) in order to reduce confusion with the "smg" (smaug) gene symbol, from which it differed only by case.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

BcDNA:RE61341

BcDNA:RH35475

CG9742

(Matera et al., 2019, Çiçek et al., 2016, Stegeman et al., 2016, Horan et al., 2015, Lu et al., 2014, Schertel et al., 2013, Metta and Schlötterer, 2010, Ni et al., 2010.12.1, Herold et al., 2009, Kroiss et al., 2008, Goshima et al., 2007, Stuart et al., 2007, Staudt et al., 2005)

(Paterson et al., 1991)

G-Sm

(Chari et al., 2008)

HD10913

(Staudt et al., 2005)

SNRPG

(Hung et al., 2020, Solis et al., 2017)

SmG

(Hsieh et al., 2019, Matera et al., 2019, Stegeman et al., 2016, Kroiss et al., 2008)

(Labourier and Rio, 2001)

snRNPG

Name Synonyms

CG9742

Small nuclear ribonucleoprotein G

Small ribonucleoprotein G

Small ribonucleoprotein particle protein SmG

snRNPG

Secondary FlyBase IDs

FBgn0030765
FBgn0047022
FBgn0062985
FBgn0022964

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32636

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VXE0

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VXE0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VXE0

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261791

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32636/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261791

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261791

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9742

MARRVEL_MODEL - MARRVEL (model organism gene)

32636

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261791

DroID - A comprehensive database of gene and protein interactions.

FBgn0261791

DRSC - Results frm RNAi screens

FBgn0261791

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

SmG_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030765

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261791

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9742

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261791

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010648

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Spliceosome

MIST (protein-protein) - An integrated Molecular Interaction Database

32636

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (50)

The following external sites may use different assemblies or annotations than FlyBase.

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