FlyBase Gene Report: Dmel\SmE

General Information

Symbol

Dmel\SmE

Species

D. melanogaster

Name

Small ribonucleoprotein particle protein SmE

Annotation Symbol

CG18591

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261790

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Small ribonucleoprotein particle protein SmE (SmE) encodes an RNA binding protein that functions as part of a heteroheptameric ring structure called the Sm core. This complex binds to spliceosomal small nuclear RNAs (e.g. U1, U2, U4 and U5) and helps to carry out pre-mRNA splicing. It also forms a heterotrimeric sub-complex with the products of SmF and SNRPG. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

snRNPE

Key Links

Genomic Location

Cytogenetic map

28D2-28D2

Sequence location

2L:7,884,930..7,885,450 [-]

Recombination map

2-29

RefSeq locus

NT_033779 REGION:7884930..7885450

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables RNA binding

inferred from electronic annotation with InterPro:IPR047575

(InterPro Project Members, 2004-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in mRNA splicing, via spliceosome

inferred from sequence or structural similarity with SGD:S000005685

(Mount and Salz, 2000)

inferred from electronic annotation with InterPro:IPR027078

(InterPro Project Members, 2004-)

inferred by curator from GO:0071011,GO:0071013

(Herold et al., 2009)

involved_in spliceosomal snRNP assembly

inferred from biological aspect of ancestor with PANTHER:PTN000127555

(GO Reference Genome Project, 2011-)

Cellular Component (11 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

located_in nucleus

inferred from direct assay

(Paterson et al., 1991)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

part_of small nuclear ribonucleoprotein complex

inferred from direct assay

(Paterson et al., 1991)

Terms Based on Predictions or Assertions (8 terms)

CV Term

Evidence

References

part_of pICln-Sm protein complex

inferred from biological aspect of ancestor with PANTHER:PTN000127555

(GO Reference Genome Project, 2011-)

part_of precatalytic spliceosome

inferred from biological aspect of ancestor with PANTHER:PTN000127555

(GO Reference Genome Project, 2011-)

part_of spliceosomal complex

inferred from sequence or structural similarity with SGD:S000005685

(Mount and Salz, 2000)

inferred from electronic annotation with InterPro:IPR027078

(InterPro Project Members, 2004-)

part_of U1 snRNP

inferred from biological aspect of ancestor with PANTHER:PTN000127555

(GO Reference Genome Project, 2011-)

part_of U2 snRNP

inferred from biological aspect of ancestor with PANTHER:PTN000127555

(GO Reference Genome Project, 2011-)

part_of U4 snRNP

inferred from biological aspect of ancestor with PANTHER:PTN000127555

(GO Reference Genome Project, 2011-)

part_of U4/U6 x U5 tri-snRNP complex

inferred from biological aspect of ancestor with PANTHER:PTN000127555

(GO Reference Genome Project, 2011-)

part_of U5 snRNP

inferred from biological aspect of ancestor with PANTHER:PTN000127555

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

U1 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE

U2 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE

U5 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE

U4-U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE

U4-U6-U5 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE

SPLICEOSOMAL SM PROTEINS

SPLICEOSOME COMPLEX A

SPLICEOSOME COMPLEX B

SPLICEOSOME COMPLEX C

SPLICEOSOME COMPLEX P

U7 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE

U7 SM PROTEINS

Protein Family (UniProt)

Belongs to the snRNP Sm proteins family. (Q9VLV5)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

U1 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -: The U1 small nuclear ribonucleoprotein particle (U1 snRNP) contains U1 snRNA and initiates spliceosome assembly by binding to the 5' splice site in pre-mRNA. (Adapted from PMID:11206553 and PMID:21441581).
U2 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -: The U2 small nuclear ribonucleoprotein particle (U2 snRNP) contains U2 snRNA. It is recruited to the spliceosome after U1 snRNP and forms a stable interaction with the branch site and 3' splice site in pre-mRNA. (Adapted from PMID:23829528 and PMID:21441581).
U5 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -: The U5 small nuclear ribonucleoprotein particle (U5 snRNP) contains U5 RNA and assembles with U4-U6 snRNP to form the U4-U6.U5 tri-snRNP. U5 snRNA interacts with the 5' and 3' exons. (Adapted from PMID:21441581).
U4-U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -: The U4/U6 small nuclear ribonucleoprotein particle (U4/U6 snRNP) is a complex that contains base-paired U4 and U6 snRNAs. U4/U6 snRNP assembles with U5 to form the U4/U6.U5 tri-snRNP. (Adapted from PMID:21441581).
U4-U6-U5 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -: U4/U6.U5 tri-snRNP is assembled from U5 and U4/U6 snRNPs. The complex contains U4 and U6 snRNAs base-paired with each other and U6 snRNA. This complex is recruited to the pre-catalytic splicing intermediate, complex B. (Adapted from PMID:21441581).
SPLICEOSOMAL SM PROTEINS -: The spliceosomal Sm proteins are common to all spliceosomal small nuclear ribonucleoproteins (snRNPs). Sm proteins assemble in a stepwise manner onto the Sm site element of the U1, U2, U4 and U5 spliceosomal snRNAs forming a ring-shaped core RNP structure. (Adapted from PMID:11226169).
SPLICEOSOME COMPLEX A -: Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex A, the pre-spliceosome, is composed of U1 and U2 snRNPs and proteins involved in recognition of the 5' splice site and branch point. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX B -: Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. After the assembly of complex A on pre-mRNA, the U4-U6 and U5 snRNPs are recruited as a preassembled tri-snRNP to form complex B. U5 snRNP binds exons at the 5' site. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX C -: Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex B undergoes a number of structural rearrangements and U4 and U1 snRNPs dissociate to generate complex C, the catalytic spliceosome. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX P -: Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex P, the post-spliceosomal complex, is formed after the catalytic removal of the intron by complex C. Complex P contains the lariat intron and spliced exons. (Adapted from PMID:24452469 and PMID:23118483).
U7 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE -: The U7 snRNP involved in histone pre-mRNA 3' end processing consists of two core components: an U7 snRNA and an unusual heptameric Sm ring. (Adapted from FBrf0168021 and FBrf0208608).
U7 SM PROTEINS -: The U7 snRNP is involved in histone mRNA 3' end processing. Sm proteins are common to all small nuclear ribonucleoproteins (snRNPs), assembling in a stepwise manner onto snRNAs, forming a ring-shaped core RNP structure. (Adapted from FBrf0168021 and FBrf0208608).

Protein Function (UniProtKB)

Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.

(UniProt, Q9VLV5)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\SmE for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VLV5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

SmE-RA

FBtr0079560

NM_135318

521

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

SmE-PA

FBpp0079182

11.1

10.10

Q9VLV5

NP_609162

AAF52576

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Interacts with the SMN complex (PubMed:18621711).

(UniProt, Q9VLV5)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VLV5

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SmE using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

SmE_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.16

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

located_in nucleus

inferred from direct assay

(Paterson et al., 1991)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

part_of small nuclear ribonucleoprotein complex

inferred from direct assay

(Paterson et al., 1991)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SmE in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\SmE

View exonic expression by tissue for Dmel\SmE

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34080/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261790

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031962

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261790

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18591

Flygut - An atlas of the Drosophila adult midgut

FBgn0261790

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of SmE

Transgenic constructs containing regulatory region of SmE

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)Exel7032

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^nub-AC-62

SmE^HMS00074

lethal, with Scer\GAL4^pnr-MD237

SmE^GD13663

lethal | female limited, with Scer\GAL4^dome-PG14

SmE^HMS00074

lethal | pupal stage, with Scer\GAL4^pnr-MD237

SmE^GD13663

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

SmE^GD13663

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

SmE^GD13663

partially lethal, with Scer\GAL4^tin.CΔ4

SmE^GD13663

Sterility

Allele

female sterile, with Scer\GAL4^VP16.otu

SmE^HMS00074

Other Phenotypes

Allele

some die during pupal stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

SmE^GD13663

Phenotype manifest in

Allele

retina, with Scer\GAL4^GMR.PU

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (19)

Hsap\SNRPE

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (21)

Rnor\Snrpe

12 of 14

Yes

Rnor\Snrpep2

11 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Snrpf

1 of 14

Rnor\Snrpg

1 of 14

Rnor\Zfp341

1 of 14

Yes

Mus musculus (laboratory mouse) (16)

Mmus\Snrpe

13 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (8)

Xtro\snrpe

11 of 13

Yes

Xtro\barhl2

1 of 13

Xtro\gimd1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (13)

Drer\snrpe

14 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\snr-6

14 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (16)

Agam\AgaP_AGAP010440

12 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (25)

Atha\AT2G18740

13 of 13

Yes

Atha\AT4G30330

13 of 13

Yes

Atha\AT3G30823

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (15)

Scer\SME1

13 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (13)

Spom\sme1

12 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:SmE. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (15)

CG6610

2 of 13

CG9344

2 of 13

SmB

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

SmF

1 of 13

SNRPG

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

SNRPE; small nuclear ribonucleoprotein polypeptide E

model of hypotrichosis 11

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

SmE^HMS00074

exacerbates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Hsieh et al., 2019)

SmE^GD13663

exacerbates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Hsieh et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SNRPE; small nuclear ribonucleoprotein polypeptide E

13 of 14

128260

HYPOTRICHOSIS 11; HYPT11

hypotrichosis 11

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

SmE - SNRPG

molecular sieving, molecular weight estimation by staining

(Chari et al., 2008)

SmE - Sf3b5

anti tag coimmunoprecipitation, peptide massfingerprinting

(Stegeman et al., 2016)

SmE - SmF

molecular sieving, molecular weight estimation by staining

(Chari et al., 2008)

SmE - Smn

molecular sieving, molecular weight estimation by staining

(Chari et al., 2008)

SmE - Spt3

anti tag coimmunoprecipitation, peptide massfingerprinting

(Stegeman et al., 2016)

SmE - icln

molecular sieving, molecular weight estimation by staining

(Chari et al., 2008)

SmE - orb2

anti tag coimmunoprecipitation, western blot

(Khan et al., 2015)

SmE - snf

anti tag coimmunoprecipitation, peptide massfingerprinting

(Stegeman et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

(UniProt, Q9VLV5 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261790

MIST (protein-protein) - An integrated Molecular Interaction Database

34080

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Spliceosome

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-29

Cytogenetic map

28D2-28D2

Sequence location

2L:7,884,930..7,885,450 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

28D2-28D2

Limits computationally determined from genome sequence between P{PZ}mts⁰²⁴⁹⁶ and P{EP}CG7231^EP2510

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-29

(FlyBase, 2016)

2-25.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

33664

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00074}attP2

13685

y¹; P{SUPor-P}SmE^KG00625 CG7102^KG00625/CyO; ry⁵⁰⁶

Kyoto

111557

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{SUPor-P}SmE^KG00625 P{neoFRT}40A/CyO y⁺

NIG-Fly

M2L-1480

y¹ w¹¹¹⁸; SmE^SK1 P{neoFRT}40A/CyO-Tb

M2L-1481

y¹ w¹¹¹⁸; SmE^SK3 P{neoFRT}40A/CyO-Tb

HMS00074

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00074}attP2

2LG-1187

y² VhaAC39-1^cho-1 v¹; P{U6-SmE.NIG.sgRNA}attP40/CyO

VDRC

v108126

P{KK101450}VIE-260B

v23569

w¹¹¹⁸; P{GD13663}v23569

Genomic Clones (8)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (22)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GM19936

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261790

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261790

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells.

(Nybakken et al., 2005)

Identified as a protein which is common to all small nuclear ribonucleoprotein particles (snRNPs).

(Paterson et al., 1991)

Relationship to Other Genes

Source for database merge of

Source for merge of: snRNPE CG18591

(Labourier and Rio, 2001)

Source for merge of: CG18591 BcDNA:GM19936

(FlyBase, 1996-)

Additional comments

Source for merge of CG18591 BcDNA:GM19936 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

BcDNA:GM19936

CG18591

(National Institute of Genetics Fly Stocks, 2022-, Matera et al., 2019, Çiçek et al., 2016, Stegeman et al., 2016, Cammarato et al., 2011, White et al., 2011, Ni et al., 2010.12.1, Herold et al., 2009, Keleman et al., 2009.8.5, Farny et al., 2008, Kroiss et al., 2008, Zhou et al., 2008, Gandhi et al., 2007, Liebl and Featherstone, 2005, Nybakken et al., 2005)

(Paterson et al., 1991)

E-Sm

(Chari et al., 2008)

SmE

(National Institute of Genetics Fly Stocks, 2022-, Hung et al., 2020, Sapiro et al., 2020, Chen et al., 2019, Foley et al., 2019, Matera et al., 2019, Yu et al., 2019, Stegeman et al., 2016, Völker-Albert et al., 2016, Khan et al., 2015, Kwon et al., 2013, Xiong et al., 2013, White et al., 2011, Gonsalvez et al., 2010, Kroiss et al., 2008)

(Labourier and Rio, 2001)

snRNPE

Name Synonyms

Small ribonucleoprotein particle protein SmE

snRNPE

Secondary FlyBase IDs

FBgn0031962
FBgn0064937
FBgn0022966

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34080

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VLV5

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VLV5

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VLV5

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34080/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261790

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261790

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG18591

MARRVEL_MODEL - MARRVEL (model organism gene)

34080

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261790

DroID - A comprehensive database of gene and protein interactions.

FBgn0261790

DRSC - Results frm RNAi screens

FBgn0261790

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

SmE_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031962

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261790

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18591

Flygut - An atlas of the Drosophila adult midgut

FBgn0261790

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261790

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010648

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Spliceosome

MIST (protein-protein) - An integrated Molecular Interaction Database

34080

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (65)

The following external sites may use different assemblies or annotations than FlyBase.

0.16

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