jf23
basic leucine zipper transcription factor - an enhancer of dpp during the development of dorsal/ventral polarity in the early embryo - a clock gene: suppression of the normal cycle of vri expression generates long-period rhythms or arrhythmicity - involved in hair and cell growth and in tracheal development W
Please see the JBrowse view of Dmel\vri for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.51
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.56
3.8, 3.4 (northern blot)
6.2, 4.9, 3.8, 3.3, 1.9, 1.6 (northern blot)
729, 610 (aa)
Predicted from cDNA.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\vri using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: vri expression is significantly higher at ZT16 than ZT4.
Comment: cyclical, peak ZT13-16
Comment: reported as plasmatocytes anlage
Comment: reference states 0-8 hr AEL
Comment: reference states >=4 hr AEL
Comment: circadian oscillating expression
Expression oscillates with the circadian cycle and peaks at ZT16, with the peak becoming less pronounced as flies age. The relative amount of mRNA is less in bodies compared to heads.
Expressed cyclically in the adult fat body.
vri mRNA shows rhythmic cycling under dark conditions with a peak at ZT14 and a trough at ZT2.
vri protein is expressed in all of the clock neurons in the adult brain. It does not colocalise with GABAergic neurons labeled with ScerGAL4Gad1.PS.
JBrowse - Visual display of RNA-Seq signals
View Dmel\vri in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Identified as a candidate gene for hypoxia-specific selection (via an experimental evolution paradigm) that is also differentially expressed between control and hypoxia-adapted larvae.
Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; increased expression in per01, tim01 and decreased expression in ClkJrk background.
Identified as one of 10 highest fold cycling genes as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Identified in S2/cycloheximide assay as a direct target of Clk mediated transcriptional regulation.
vri RNA levels oscillate with a circadian rhythm. This cycling is required for a functional circadian clock.
Mutant alleles have embryonic ventralised phenotype.
Mutant embryos show defects occurring in preblastoderm stages.
