FB2024_03 , released June 25, 2024
Allele: Dmel\sloth2KO
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General Information
Symbol
Dmel\sloth2KO
Species
D. melanogaster
Name
FlyBase ID
FBal0386638
Feature type
allele
Associated gene
Dmel\sloth2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Bosch et al., 2022)
Mutagen
CRISPR/Cas9
(Bosch, 2023.8.3, Bosch et al., 2022)
Progenitor genotype
Cytology
Description

Indel (24bp deletion, 1bp insertion) in sloth2 that results in a frameshift.

(Bosch, 2023.8.3)

A frame-shift indel within the sloth2 coding region.

(Bosch et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
X:7,011,920..7,011,943 [+]
Comment:

24bp deletion and insertion of an A in the sloth2 coding region leads to a frameshift.

Inserted_sequence:

A

(Bosch, 2023.8.3, Bosch et al., 2022)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      sloth2KO has lethal | male phenotype, suppressible by Scer\GAL4da.PU/Hsap\UQCC6UAS.cBa

      (Bosch et al., 2022)
      NOT suppressed by
      Statement
      Reference

      sloth2KO has lethal | male phenotype, non-suppressible by Scer\GAL4da.PU/Hsap\UQCC5UAS.cBa

      (Bosch et al., 2022)

      sloth2KO has lethal | male phenotype, non-suppressible by sloth1+tBa

      (Bosch et al., 2022)

      sloth2KO has lethal | male phenotype, non-suppressible by Scer\GAL4da.PU/sloth1UAS.cBa

      (Bosch et al., 2022)
      Other
      Statement
      Reference

      sloth1KO, sloth2KO has viable | female phenotype

      (Bosch et al., 2022)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG423083
      (Bosch, 2023.8.3)
      sloth2-KO
      (Bosch et al., 2022)
      sloth2KO
      Name Synonyms
      Secondary FlyBase IDs
        References (2)