FlyBase Allele Report: Dmel\Frl[59]

FB2024_03 , released June 25, 2024

FB2024_03 , released June 25, 2024

Allele: Dmel\Frl⁵⁹

General Information

Symbol

Dmel\Frl⁵⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0362208

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Tóth et al., 2022)

Mutagen

(Dehapiot et al., 2020)

Progenitor genotype

Cytology

Description

Deletion of approximately 8640bp that removes part of Frl.

(Dehapiot et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell size | embryonic stage

(Tóth et al., 2022)

(Gazsó-Gerhát et al., 2023, Földi et al., 2022)

Phenotype Manifest In

(Tóth et al., 2022)

embryonic dorsal epidermis

(Tóth et al., 2022)

Detailed Description

Statement

Reference

Amnioserosa cells of Frl⁵⁹ mutant embryos are bigger and show larger perimeter compare to controls.

Frl⁵⁹ embryos exhibit dorsal closure phenotypes, such as decreased zipping speed, puckering of the dorsal epidermis, a malformed canthus, disintegration of the Amnioserosa, and increased ration of dorsal hole length/width; some embryos also arrests at this stage.

(Tóth et al., 2022)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

DAAM^Ex4, Frl⁵⁹ has abnormal neuroanatomy | P-stage phenotype, enhanceable by Frl^I773A.UAS/Scer\GAL4^54C

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has abnormal neuroanatomy | P-stage phenotype, enhanceable by Frl^I773A.UAS/Scer\GAL4^GMR.PU

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has abnormal neuroanatomy | P-stage phenotype, enhanceable by DAAM^{I732A.UAS.Tag:FLAG}/Scer\GAL4^GMR.PU

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has abnormal neuroanatomy | P-stage phenotype, enhanceable by DAAM^{I732A.UAS.Tag:FLAG}/Scer\GAL4^54C

(Gazsó-Gerhát et al., 2023)

Suppressed by

Statement

Reference

DAAM^Ex4, Frl⁵⁹ has abnormal neuroanatomy | P-stage phenotype, suppressible | partially by Scer\GAL4^54C/Frl^UAS.cGGa

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has abnormal neuroanatomy | P-stage phenotype, suppressible by Frl^UAS.cGGa/Scer\GAL4^GMR.PU

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has abnormal neuroanatomy | P-stage phenotype, suppressible by DAAM^UAS.PB/Scer\GAL4^GMR.PU

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has abnormal neuroanatomy | P-stage phenotype, suppressible | partially by DAAM^UAS.PB/Scer\GAL4^54C

(Gazsó-Gerhát et al., 2023)

Enhancer of

Statement

Reference

Frl⁵⁹ is an enhancer of abnormal neuroanatomy | P-stage phenotype of Cdc42²

(Gazsó-Gerhát et al., 2023)

Other

Statement

Reference

DAAM^Ex4, Frl⁵⁹ has abnormal cell shape | P-stage phenotype

(Gazsó-Gerhát et al., 2023)

DAAM^HMS01978, Frl⁵⁹, Scer\GAL4^GMR.PU has abnormal neuroanatomy | P-stage phenotype

(Gazsó-Gerhát et al., 2023)

Frl⁵⁹, zip² has abnormal neuroanatomy | P-stage phenotype

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has visible | adult stage phenotype

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has lethal - all die during pharate adult stage phenotype

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, DAAM^RNAi.PD.UAS, Frl⁵⁹, Scer\GAL4^GMR.PU has abnormal neuroanatomy | P-stage phenotype

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has abnormal neuroanatomy | P-stage phenotype

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has partially lethal - majority die phenotype

(Földi et al., 2022)

DAAM^Ex4, Frl⁵⁹ has abnormal neuroanatomy | embryonic stage phenotype

(Földi et al., 2022)

DAAM^Ex4, Frl⁵⁹ has some die during P-stage phenotype

(Földi et al., 2022)

DAAM^Ex4, Frl⁵⁹ has some die during larval stage phenotype

(Földi et al., 2022)

Phenotype Manifest In

Enhanced by

Statement

Reference

DAAM^Ex4, Frl⁵⁹ has ommatidium | P-stage phenotype, enhanceable by Frl^I773A.UAS/Scer\GAL4^54C

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has ommatidium | P-stage phenotype, enhanceable by Frl^I773A.UAS/Scer\GAL4^GMR.PU

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has ommatidium | P-stage phenotype, enhanceable by DAAM^{I732A.UAS.Tag:FLAG}/Scer\GAL4^GMR.PU

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has ommatidium | P-stage phenotype, enhanceable by DAAM^{I732A.UAS.Tag:FLAG}/Scer\GAL4^54C

(Gazsó-Gerhát et al., 2023)

Suppressed by

Statement

Reference

DAAM^Ex4, Frl⁵⁹ has ommatidium | P-stage phenotype, suppressible by Frl^UAS.cGGa/Scer\GAL4^GMR.PU

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has ommatidium | P-stage phenotype, suppressible | partially by Scer\GAL4^54C/Frl^UAS.cGGa

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has ommatidium | P-stage phenotype, suppressible by DAAM^UAS.PB/Scer\GAL4^GMR.PU

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has ommatidium | P-stage phenotype, suppressible | partially by DAAM^UAS.PB/Scer\GAL4^54C

(Gazsó-Gerhát et al., 2023)

Enhancer of

Statement

Reference

Frl⁵⁹ is an enhancer of ommatidium | P-stage phenotype of Cdc42²

(Gazsó-Gerhát et al., 2023)

Other

Statement

Reference

DAAM^Ex4, Frl⁵⁹ has interommatidial cell | P-stage phenotype

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has rhabdomere of eye photoreceptor cell | P-stage phenotype

(Gazsó-Gerhát et al., 2023)

DAAM^HMS01978, Frl⁵⁹, Scer\GAL4^GMR.PU has ommatidium | P-stage phenotype

(Gazsó-Gerhát et al., 2023)

Frl⁵⁹, zip² has ommatidium | P-stage phenotype

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has eye phenotype

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, DAAM^RNAi.PD.UAS, Frl⁵⁹, Scer\GAL4^GMR.PU has ommatidium | P-stage phenotype

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has ommatidium | P-stage phenotype

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has secondary pigment cell | P-stage phenotype

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has tertiary pigment cell | P-stage phenotype

(Gazsó-Gerhát et al., 2023)

DAAM^Ex4, Frl⁵⁹ has axon microtubule bundle | embryonic stage phenotype

(Földi et al., 2022)

DAAM^Ex4, Frl⁵⁹ has axonal growth cone | embryonic stage phenotype

(Földi et al., 2022)

DAAM^Ex4, Frl⁵⁹ has larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype

(Földi et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Frl⁵⁹

frl⁵⁹

(Gazsó-Gerhát et al., 2023, Földi et al., 2022, Tóth et al., 2022, Dehapiot et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections