FB2024_03 , released June 25, 2024
Allele: Dmel\Gfat1Z352
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General Information
Symbol
Dmel\Gfat1Z352
Species
D. melanogaster
Name
FlyBase ID
FBal0351520
Feature type
allele
Associated gene
Dmel\Gfat1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Honda, 2019.6.3)
Progenitor genotype
Cytology
Description

Molecular lesion given with respect to transcript model Gfat1-RN.

(Cotsworth et al., 2022)

Amino acid replacement: L556M.

(Cotsworth et al., 2022)

Amino acid replacement: I556M.

(Honda, 2019.6.3)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:4,137,371..4,137,371 [+]
Nucleotide change:

T4137371A

Amino acid change:

L588M | Gfat1-PA; L567M | Gfat1-PD; L328M | Gfat1-PF; L579M | Gfat1-PH; L537M | Gfat1-PJ; L387M | Gfat1-PK; L576M | Gfat1-PL; L559M | Gfat1-PM; L588M | Gfat1-PN

Reported amino acid change:

L588M

Comment:

Amino acid change reported relative to Gfat1-PN. Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change. The mutation was also been reported as L556M in Figure 4 and in personal communication FBrf0242880, which appear to be a typo.

(Cotsworth et al., 2022)
point_mutation
3R:4,137,371..4,137,371 [+]
Nucleotide change:

T4137371A

Amino acid change:

L588M | Gfat1-PA; L567M | Gfat1-PD; L328M | Gfat1-PF; L579M | Gfat1-PH; L537M | Gfat1-PJ; L387M | Gfat1-PK; L576M | Gfat1-PL; L559M | Gfat1-PM; L588M | Gfat1-PN

Reported amino acid change:

L588M

Comment:

Amino acid change reported relative to Gfat1-PN. Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change. The mutation was also been reported as L556M in Figure 4 and in personal communication FBrf0242880, which appear to be a typo.

(Cotsworth et al., 2022)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Originated in the Zuker screen (FBrf0179036).

      (Honda, 2019.6.3)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Gfat1Z352
      (Honda, 2019.6.3)
      zep3-52
      (Cotsworth et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)