FB2024_03 , released June 25, 2024
Allele: Cint\AOXmut.UAS
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General Information
Symbol
Cint\AOXmut.UAS
Species
C. intestinalis
Name
FlyBase ID
FBal0350377
Feature type
allele
Associated gene
Cint\AOX
Associated Insertion(s)
Carried in Construct
P{UAS-Cint\AOX.mut}
Also Known As
UAS-mutAOX
Transgenic product class
missense_variant
(Andjelković et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Andjelković et al., 2015)
Mutagen
in vitro construct
(Andjelković et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-Cint\AOX.mut}
Cytology
Description

UASt regulates expression of Cint\AOX bearing 4 mutations at conserved residues at the predicted diiron centre (E239A, H242A, E344A, H347A). These mutations are predicted to destroy the binding of iron to the active site, whilst only minimally disturbing the overall structure of each subunit.

(Andjelković et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Cint\AOX
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Cint\AOXmut.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)