FB2024_03 , released June 25, 2024
Allele: Dmel\chinmoST
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General Information
Symbol
Dmel\chinmoST
Species
D. melanogaster
Name
Sex Transformation
FlyBase ID
FBal0320047
Feature type
allele
Associated gene
Dmel\chinmo
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Ma et al., 2014)
Mutagen
spontaneous
(Ma et al., 2014)
Progenitor genotype
Cytology
Description

10bp deletion in the 5'UTR.

(Ma et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      chinmoST/chinmoST mutant males are fertile and exhibit normal testis morphology at 0-1 days old, but display a progressive change in testis morphology, wherein they start to exhibit somatic cells with a follicle cell-like phenotype. At 2-3 days, aggregates of epithelial somatic cells appear adjacent to the hub. Over time, somatic cell aggregates acquire additional cells and extend away from the testis apex; older differentiating germ cells and cyst cells are displaced toward the basal end of testis. In 7-9-day old males, somatic cell aggregates adjacent to the hub remain and a monolayer of columnar epithelial cells lines the testis periphery, resembling ovarian follicle cells; germ cells are restricted to the lumen of the tissue and are arrested at the spermatogonial stage. The arrangement of somatic cells resembles somatic follicle cells within the Drosophila ovary. By 2-3 weeks, arrested germ cells are observed to degenerate. Somatic cells resembling stalk cells become apparent in older chinmoST/chinmoST testes.

      chinmoST/chinmoKG05386, chinmoST/chinmoM33, chinmoST/chinmo1, chinmoST/Df(2L)S2, chinmoST/Df(2L)ast2, chinmoST/Df(2L)dp-79b, chinmoST/Df(2L)Exel6005, chinmoST/Df(2L)ED7762, chinmoST/Df(2L)BSC480, or chinmoST/Df(2L)BSC521 mutant males exhibit somatic cells with a follicle cell-like phenotype.

      (Ma et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      chinmoST is rescued by chinmoUAS.fl

      (Ma et al., 2014)
      Comments

      Expression of chinmoScer\UAS.fl under the control of Scer\GAL4C587 rescues the somatic cell defects of chinmoST/chinmoST mutant testes.

      (Ma et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      chinmoST
      (Grmai et al., 2018, Ma et al., 2014)
      Name Synonyms
      Sex Transformation
      Secondary FlyBase IDs
        References (2)