FB2024_03 , released June 25, 2024
Allele: Dmel\chinmoM33
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General Information
Symbol
Dmel\chinmoM33
Species
D. melanogaster
Name
FlyBase ID
FBal0103704
Feature type
allele
Associated gene
Dmel\chinmo
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Welte, 2000.2.23)
Progenitor genotype
Cytology
Description

chinmoM33 encodes a missense mutation (F88I) in the BTB domain.

(Zhu et al., 2006)

Amino acid replacement: F88I.

(Zhu et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:1,694,367..1,694,367 [+]
Nucleotide change:

T1694367A

Amino acid change:

F88I | chinmo-PA; F88I | chinmo-PD; F88I | chinmo-PE; F88I | chinmo-PF; F88I | chinmo-PG; F88I | chinmo-PH

Reported amino acid change:

F88I

Comment:

Site of nucleotide substitution inferred by FlyBase based on reported amino acid change.

(Zhu et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      chinmoM33/chinmo1, chinmoM33/Df(2L)S2, chinmoM33/Df(2L)ast2, chinmoM33/Df(2L)dp-79b, chinmoM33/Df(2L)Exel6005, chinmoM33/Df(2L)ED7762, chinmoM33/Df(2L)BSC480, or chinmoM33/Df(2L)BSC521 mutants are lethal.

      chinmoM33/chinmoM33 mutant somatic cyst stem cell clones are lost from the adult testis stem cell niche and testes do not exhibit any signs of sex transformation.

      chinmoST/chinmoM33 or chinmoKG05386/chinmoM33 mutant males exhibit somatic cells with a follicle cell-like phenotype.

      (Ma et al., 2014)

      Few escapers with eye-antennal disc chinmoM33 clones (in the Minute background) exhibit excess head cuticle, reduction of the eye field, partial or complete loss of antennal segments when compared to controls.

      At 2 days post-clone induction (pci), chinmoM33 germline stem cell (GSC, Vasa staining) clones are in contact with the Hub (a group of somatic cells in testis) and cyst stem cell (CySC, Zfh1 or Tj staining) clones envelope germ line cells; at 7 days pci there are numerous GSC clones still in contact with the Hub while there are not any CySc clones but there are Tj+ somatic clones outside of the Hub when compared to control flip-out clones.

      (Flaherty et al., 2010)

      There appear to be far more projections of the pioneer α/β type in chinmoM33 mutant neuroblast clones, with qualitatively fewer γ type neurons.

      (Zhu et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      M. Postner

      (Welte, 2000.2.23)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      chinmoM33
      (Ma et al., 2014, Kuzin et al., 2011, Flaherty et al., 2010, Zhu et al., 2006)
      l(2)04111M33
      (Zhu et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)