FB2024_03 , released June 25, 2024
Allele: Zzzz\CAGSu3.UAS.Tag:MYC
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General Information
Symbol
Zzzz\CAGSu3.UAS.Tag:MYC
Species
a. artificial
Name
FlyBase ID
FBal0319633
Feature type
allele
Associated gene
Zzzz\CAG
Associated Insertion(s)
Carried in Construct
P{UAS-Su3.myc}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Kazantsev et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-Su3.myc}
Cytology
Description

UAS regulatory sequences drive expression of a 'suppressor' protein that has been shown to disrupt aggregation of expanded-polyQ repeat proteins in vitro. The suppressor sequence consists of the first 17 amino acids residues of Hsap\HTT, a 25Q polyQ-repeat, a spacer region derived from helical regions from the C-terminal region of TBP, a second 25Q polyQ-repeat and a Tag:MYC tag.

(Kazantsev et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Zzzz\CAG
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Hsap\HDSu3.Scer\UAS.T:Zzzz\CAG,T:Hsap\MYC significantly suppresses the loss of photoreceptor neurons seen in flies expressing Zzzz\CAGQ108.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG under the control of Scer\GAL4elav.PLu. Co-expression of Hsap\HDSu3.Scer\UAS.T:Zzzz\CAG,T:Hsap\MYC significantly suppresses the loss of photoreceptor neurons seen in flies expressing Zzzz\CAGQ48.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG under the control of Scer\GAL4elav.PLu.

      (Kazantsev et al., 2002)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Hsap\HDSu3.Scer\UAS.T:Zzzz\CAG,T:Hsap\MYC
      Hsap\HTTSu3.Scer\UAS.T:Zzzz\CAG,T:Hsap\MYC
      Zzzz\CAGSu3.Scer\UAS.T:Hsap\MYC
      Zzzz\CAGSu3.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0319578
      • FBal0137486
      References (2)