FB2024_03 , released June 25, 2024
Allele: Dmel\nito1
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General Information
Symbol
Dmel\nito1
Species
D. melanogaster
Name
FlyBase ID
FBal0316512
Feature type
allele
Associated gene
Dmel\nito
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Yan and Perrimon, 2015)
Mutagen
P-element activity
(Yan and Perrimon, 2015)
Progenitor genotype
P{EPg}nitoHP25329
(Yan and Perrimon, 2015)
Cytology
Description

Imprecise excision of P{EPg}nitoHP25329.

(Yan and Perrimon, 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:7,962,495..7,963,851 [+]
(Yan, 2016.1.15)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      nito1 homozygous animals die during larval stages. The mutation causes lethality in both females and males.

      (Yan and Perrimon, 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      FlaccC, nito[+], nito1, Flacc[+] is a suppressor of lethal | female phenotype of vir2f

      (Knuckles et al., 2018)
      NOT Suppressor of
      Statement
      Reference

      nito[+]/nito1 is a non-suppressor of lethal | female phenotype of vir2f

      (Knuckles et al., 2018)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Df(2L)BSC209/+;nito1/+ double heterozygous females show significantly reduced viability compared to Df(2L)BSC209 single heterozygotes.

      The complete lethality of vir2f homozygous females cannot be suppressed by combination with a single copy of nito1 or FlaccC individually but heterozygosity for both does partially restore viability of the vir2f/vir2f females.

      (Knuckles et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      nito1
      (Kan et al., 2017, Yan, 2016.1.15, Yan and Perrimon, 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)