FlyBase Allele Report: Dmel\Su(var)3-7[14]

General Information

Symbol

Dmel\Su(var)3-7¹⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0304387

Feature type

allele

Associated gene

Dmel\Su(var)3-7

Associated Insertion(s)

TI{TI}Su(var)3-7¹⁴

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

ends-in gene targeting

(Seum et al., 2002)

FLPase

(Seum et al., 2002)

I-SceI

(Seum et al., 2002)

Progenitor genotype

Associated Insertion(s)

TI{TI}Su(var)3-7¹⁴

Cytology

Description

Duplication at the Su(var)3-7 locus, with each copy of the gene separated by a y⁺²⁰⁸³ marker. The 5' copy is a fusion protein containing a wild-type copy of Su(var)3-7 fused at its C-terminus in frame with 157 amino acids of the y protein (this structure is due to the cloning procedure used to make the donor construct). The 3' copy contains a 3.7kb deletion which removes most of the Su(var)3-7 gene.

(Seum et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during second instar larval stage | maternal effect

(Seum et al., 2002)

suppressor of variegation, with In(1)w^m4h

(Seum et al., 2002)

suppressor of variegation, with In(2)Heidi-P{Winkelried}D

(Seum et al., 2002)

suppressor of variegation, with In(2R)bw^VDe2

(Seum et al., 2002)

viable

(Seum et al., 2002)

Phenotype Manifest In

polytene chromosome | male

(Spierer et al., 2005)

polytene chromosome chromocenter

(Spierer et al., 2005)

polytene chromosome chromocenter (with Su(var)3-7⁹)

(Spierer et al., 2005)

Detailed Description

Statement

Reference

Su(var)3-7¹⁴/+ does not significantly affect the size of the adult eye, as compared to wild type.

(Tsai et al., 2016)

The X chromosome is shorter than normal and bloated in polytene chromosome squashes from male homozygous Dp(3;3)Su(var)3-7¹⁴ third instar larvae.

The chromocenter has slightly loose morphology in polytene chromosome squashes from homozygous Dp(3;3)Su(var)3-7¹⁴ third instar larvae.

The chromocenter has loose morphology in polytene chromosome squashes from Dp(3;3)Su(var)3-7¹⁴/Dp(3;3)Su(var)3-7⁹ third instar larvae.

The X chromosome is shorter than normal and bloated in polytene chromosome squashes from male homozygous Su(var)3-7¹⁴ third instar larvae.

The chromocenter has slightly loose morphology in polytene chromosome squashes from homozygous Su(var)3-7¹⁴ third instar larvae.

The chromocenter has loose morphology in polytene chromosome squashes from Su(var)3-7¹⁴/Su(var)3-7⁹ third instar larvae.

(Spierer et al., 2005)

Loss of maternal and zygotic Su(var)3-7 is lethal.

(Seum et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Su(var)3-7¹⁴/Su(var)3-7[+] is a non-suppressor of abnormal size | adult stage phenotype of Scer\GAL4^ey.PU, Trl^519.UAS

(Tsai et al., 2016)

Other

Statement

Reference

P{P-Sal}Pak3^P-Sal, P{lacW}Dplac, Su(var)3-7¹⁴ has suppressor of variegation phenotype

(Bushey and Locke, 2004)

Phenotype Manifest In

Suppressed by

Statement

Reference

Su(var)3-7¹⁴ has polytene chromosome | male phenotype, suppressible by mle¹/mle¹

(Spierer et al., 2005)

NOT Suppressor of

Statement

Reference

Su(var)3-7¹⁴/Su(var)3-7[+] is a non-suppressor of eye | adult stage phenotype of Scer\GAL4^ey.PU, Trl^519.UAS

(Tsai et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Su(var)3-7¹⁴/+ fails to restore the eye size of flies expressing Trl^519.Scer\UAS under the control of Scer\GAL4^dpp.PU.

(Tsai et al., 2016)

Homozygosity for mle¹ suppresses the bloated X chromosome phenotype seen in polytene chromosome squashes from male homozygous Su(var)3-7¹⁴ third instar larvae.

Homozygosity for mle¹ suppresses the bloated X chromosome phenotype seen in polytene chromosome squashes from male homozygous Dp(3;3)Su(var)3-7¹⁴ third instar larvae.

(Spierer et al., 2005)

When P{P-Sal}Pak3^P-Sal is present, the w gene of the P{lacW}ci^Dplac insertion variegates, resulting (in a w[-] background) in an eye that is mostly white with a few patches of red ommatidia. This P-element-dependent silencing of P{lacW}ci^Dplac is dominantly suppressed by Su(var)3-7¹⁴.

When P{P-Sal}89D is present, the w gene of the P{lacW}ci^Dplac insertion variegates, resulting (in a w^- background) in an eye that is mostly white with a few patches of red ommatidia. This P-element-dependent silencing of P{lacW}ci^Dplac is dominantly suppressed by Dp(3;3)Su(var)3-7¹⁴.

(Bushey and Locke, 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Su(var)3-7¹⁴ is partially rescued by Su(var)3-7^FL.hs.Tag:HA

(Seum et al., 2002)

Su(var)3-7¹⁴ is partially rescued by Su(var)3-7^+t6.5

(Seum et al., 2002)

Comments

Loss of maternal and zygotic Su(var)3-7 is lethal.

(Seum et al., 2002)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dp(3;3)Su(var)3-7¹⁴

Su(var)3-7^14.3'

Su(var)3-7^14.5'

Su(var)3-7¹⁴

(Tsai et al., 2016, Jaquet et al., 2006, Spierer et al., 2005, Bushey and Locke, 2004, Seum et al., 2002)

Name Synonyms

Secondary FlyBase IDs

FBal0147399
FBal0147398
FBab0037617

References (5)

Report Sections

Open Close