FB2024_03 , released June 25, 2024
Allele: Dmel\Su(var)3-7FL.hs.Tag:HA
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General Information
Symbol
Dmel\Su(var)3-7FL.hs.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0141357
Feature type
allele
Associated gene
Dmel\Su(var)3-7
Associated Insertion(s)
Carried in Construct
P{hs-Su(var)3-7.FL}
Also Known As
HA:FL
Key Links
Transgenic product class
inframe_deletion
(Jaquet et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Jaquet et al., 2002)
Mutagen
in vitro construct
(Jaquet et al., 2002)
Progenitor genotype
Carried in construct
P{hs-Su(var)3-7.FL}
Cytology
Description

A heat shock promoter drives expression of a 3.4kb cDNA fragment encoding Su(var)3-7 amino acids 37 to 1169. The Su(var)3-7 protein is tagged at the N-terminal end with Tag:HA.

(Jaquet et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Su(var)3-7
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Su(var)3-7FL.hs.T:Ivir\HA1 enhances variegation of w (carried on the P{Winkelried}D insertion) in In(2)Heidi-P{Winkelried}D flies. Expression of Su(var)3-7FL.hs.T:Ivir\HA1 enhances variegation of w in In(1)wm4h.

      (Jaquet et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Su(var)3-7FL.hs.Tag:HA is a suppressor of lethal | third instar larval stage phenotype of mle1

      (Spierer et al., 2008)
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The expression of msl-2Hsp83.PK in females overexpressing Su(var)3-7FL.hs.T:Ivir\HA1 causes the X chromosomes to condense as typically seen only in males overexpressing Su(var)3-7FL.hs.T:Ivir\HA1.

      The presence of Su(var)3-7FL.hs.T:Ivir\HA1 suppresses the mle1 phenotype resulting in almost normal male X chromosome morphology.

      A Su(var)3-7R2a8 background kills males expressing msl-1Hsp83.PC-msl-2Hsp83.PK. Homozygous Su(var)3-7R2a8 females crossed with transgenic msl-1Hsp83.PC-msl-2Hsp83.PK males produce only 6% of male adult progeny harbouring the transgenes compared to 48% if the mothers are heterozygous for Su(var)3-7R2a8.

      (Spierer et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Su(var)3-7FL.hs.Tag:HA partially rescues Su(var)3-714

      (Seum et al., 2002)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Su(var)3-7FL.hs.T:Ivir\HA1
      Su(var)3-7FL.hs.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (4)