FB2024_03 , released June 25, 2024
Allele: Dmel\Mmp2GPI.EGFP
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General Information
Symbol
Dmel\Mmp2GPI.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0299613
Feature type
allele
Associated gene
Dmel\Mmp2
Associated Insertion(s)
Carried in Construct
PBac{Mmp2-EGFP-GPI}
Key Links
Transgenic product class
genomic_DNA
(Wang and Page-McCaw, 2014)
wild_type
(Wang and Page-McCaw, 2014)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Wang and Page-McCaw, 2014)
wild_type
(Wang and Page-McCaw, 2014)
Mutagen
in vitro construct
(Wang and Page-McCaw, 2014)
Progenitor genotype
Carried in construct
PBac{Mmp2-EGFP-GPI}
Cytology
Description

Genomic fragment corresponding to BAC clone CH321-81G18, containing the entire 73kb Mmp2 gene region plus approximately 17kb 5' and 4kb 3' sequence (coordinates 2R:9607564..9701338 , release 6 sequence). A EGFP tag has been inserted (after residue S710) before the Mmp2 GPI attachment sequence.

(Wang and Page-McCaw, 2014)
Allele components
Component
Use(s)
Regulatory region(s)
Mmp2
Encoded product / tool
Mmp2
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Mmp2GPI.EGFP rescues Df(2R)BSC132/Mmp2Y53N

      (Wang and Page-McCaw, 2014)
      Partially rescues

      Mmp2GPI.EGFP partially rescues Mmp2W307stop/Mmp2218

      (Wang and Page-McCaw, 2014)
      Comments

      Mmp2GPI.T:Avic\GFP-EGFP completely rescues the pupal lethality of Mmp2 mutants. It rescues the lifespan, fertility and follicle cell defects of Mmp2Y53N/Df(2R)BSC132 flies, but not of Mmp2W307stop/Mmp2218 flies.

      (Wang and Page-McCaw, 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mmp2GPI.EGFP
      Mmp2GPI.T:Avic\GFP-EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)