FB2024_03 , released June 25, 2024
Allele: Dmel\Mmp2218
Open Close
General Information
Symbol
Dmel\Mmp2218
Species
D. melanogaster
Name
FlyBase ID
FBal0150753
Feature type
allele
Associated gene
Dmel\Mmp2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Page-McCaw et al., 2003)
Progenitor genotype
Cytology
Description

A 3' splice site mutation: the invariant AG dinucleotide at the 3' splice site before exon 5 is mutated to AA, abolishing the reading frame from the middle of the catalytic domain.

(Page-McCaw et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:9,614,973..9,614,973 [-]
Nucleotide change:

G9614973A

Reported nucleotide change:

G?A

Comment:

G to A nucleotide change in the splice acceptor site.

(Page-McCaw et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mmp2W307stop/Mmp2218 transheterozygotes exhibit a decrease in lifespan compared to controls.

      (Wang and Page-McCaw, 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The larval lethality due to Mmp1Q112stop/Mmp12 is enhanced by Mmp2218/Mmp2W307stop from 84% survival to 3rd instar and 7% pupariating to 54% survival to 3rd instar and 4% pupariating.

      (Page-McCaw et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Mmp2W307stop/Mmp2218 is partially rescued by Mmp2GPI.EGFP

      (Wang and Page-McCaw, 2014)
      Comments

      Mmp2GPI.T:Avic\GFP-EGFP completely rescues the pupal lethality of Mmp2 mutants. It does not rescue the lifespan, fertility and follicle cell defects of Mmp2W307stop/Mmp2218 flies.

      (Wang and Page-McCaw, 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Mmp2218
      Mmp2218ss
      (Wang and Page-McCaw, 2014)
      mmp2ss218
      (Dear et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)