FlyBase Allele Report: Hsap\MYC[UAS.S]

General Information

Symbol

Hsap\MYC^UAS.S

Species

H. sapiens

Name

FlyBase ID

FBal0281058

Feature type

allele

Associated gene

Hsap\MYC

Associated Insertion(s)

Carried in Construct

P{UAS-hMYC.S}

Also Known As

UAS-c-MycS

Key Links

Transgenic product class

wild_type

(Benassayag et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Benassayag et al., 2005)

Mutagen

in vitro construct

(Benassayag et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-hMYC.S}

Cytology

Description

UASt regulatory sequences drive expression of the Hsap\MYC S isoform.

(Benassayag et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\MYC

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | somatic clone, with Scer\GAL4^Act5C.PP

(Benassayag et al., 2005)

decreased cell number | adult stage, with Scer\GAL4^en-e16E

(Wang et al., 2008)

increased cell size | adult stage, with Scer\GAL4^en-e16E

(Wang et al., 2008)

increased cell size | somatic clone, with Scer\GAL4^Act5C.PP

(Benassayag et al., 2005)

viable, with Scer\GAL4^Myc-PG45

(Benassayag et al., 2005)

Phenotype Manifest In

wing | posterior, with Scer\GAL4^en-e16E

(Wang et al., 2008)

wing disc | somatic clone, with Scer\GAL4^Act5C.PP

(Benassayag et al., 2005)

Detailed Description

Statement

Reference

Expression of Hsap\MYC^Scer\UAS.S under the control of Scer\GAL4^en-e16E has no effect on the overall size of the posterior wing compartment, but cell number is reduced and the size of the cells is increased.

(Wang et al., 2008)

Females expressing Hsap\MYC^Scer\UAS.S under the control of Scer\GAL4^dm-PG45 are viable.

Clones in the wing disc expressing two copies of Hsap\MYC^Scer\UAS.S under the control of Scer\GAL4^Act5C.PP show an increase in cell size and a reduction in the fraction of cells in G[[1]] with a concomitant increase in cells in S or G[[2]] phase compared to controls. The clones do not show detectable levels of apoptosis.

Expression of Hsap\MYC^Scer\UAS.S under the control of Scer\GAL4^ap-md544 does not induce apoptosis in the wing disc.

(Benassayag et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\MYC^UAS.S, Scer\GAL4^sca-537.4 is a suppressor | partially of visible phenotype of Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^sca-537.4

(Wang et al., 2008)

Hsap\MYC^UAS.S, Scer\GAL4^en-e16E is a suppressor of visible phenotype of Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\MYC^UAS.S, Scer\GAL4^en-e16E is a suppressor of abnormal size phenotype of Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\MYC^UAS.S, Scer\GAL4^en-e16E is a suppressor of decreased cell size | adult stage phenotype of Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\MYC^UAS.S, Scer\GAL4^en-e16E is a suppressor of decreased cell number | adult stage phenotype of Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E

(Wang et al., 2008)

Scer\GAL4^Myc-PG45/Hsap\MYC^UAS.S is a suppressor | partially of lethal phenotype of Myc^PG45

(Benassayag et al., 2005)

Scer\GAL4^Myc-PG45/Hsap\MYC^UAS.S is a suppressor | cell autonomous | partially | somatic clone of decreased cell growth rate | somatic clone phenotype of Myc^PG45

(Benassayag et al., 2005)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\MYC^UAS.S, Scer\GAL4^sca-537.4 is a suppressor | partially of scutellar bristle phenotype of Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^sca-537.4

(Wang et al., 2008)

Hsap\MYC^UAS.S, Scer\GAL4^en-e16E is a suppressor of wing | posterior phenotype of Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E

(Wang et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\MYC^Scer\UAS.S partially suppresses the growth phenotypes seen in the wings and bristles of flies expressing Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E or Scer\GAL4^sca-537.4 respectively.

(Wang et al., 2008)

Expression of Hsap\MYC^Scer\UAS.S under the control of Scer\GAL4^dm-PG45 partially rescues the lethality of dm^PG45 males. Surviving adult males are fertile, but have thin bristles. The size of the wings and of the wing cells is reduced approximately 15% compared to wild type.

The reduced size of homozygous dm^PG45 clones in the imaginal disc is partially suppressed if the clones are expressing Hsap\MYC^Scer\UAS.S under the control of Scer\GAL4^dm-PG45 (the double mutant clones are approximately 70% the size of the wild-type twin spots).

(Benassayag et al., 2005)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\MYC^Scer\UAS.S

Hsap\MYC^UAS.S

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close