FlyBase Allele Report: Dmel\Ge-1[Δ5]

General Information

Symbol

Dmel\Ge-1^Δ5

Species

D. melanogaster

Name

FlyBase ID

FBal0266002

Feature type

allele

Associated gene

Dmel\Ge-1

Associated Insertion(s)

?{}Ge-1^Δ5

Carried in Construct

Also Known As

dGe-1^Δ5

Key Links

Allele class

hypomorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Fan et al., 2011)

Mutagen

P-element activity

(Fan et al., 2011)

Progenitor genotype

P{GSV2}Ge-1^GS5005

(Fan et al., 2011)

Associated Insertion(s)

?{}Ge-1^Δ5

Caused by aberration

Df(2L)Ge-1^Δ5

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a 681bp deletion covering most of the Ge-1 5'UTR and extending into the 3'UTR of the neighbouring upstream gene (Reps). 30bp of unknown origin have also been inserted into this region.

(Fan et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Fan et al., 2011)

Phenotype Manifest In

dorsal appendage | germline clone

(Fan et al., 2011)

embryonic/larval cuticle | germline clone

(Fan et al., 2011)

ventral denticle belt | germline clone

(Fan et al., 2011)

Detailed Description

Statement

Reference

Approximately 17% of eggs derived from homozygous female germline clones develop dorsal appendages. Approximately 55% of eggs derived from homozygous female germline clones develop into embryos and hatch. Of the remaining 45%, half show a normal cuticle. Around 3.2% develop into embryos displaying a weak posterior phenotype (embryo lacks at least on abdominal denticle belt) and 0.8% develop a strong posterior phenotype (embryo lacks all abdominal denticle belts).

(Fan et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Ge-1^Δ5 has ventral denticle belt | germline clone phenotype, enhanceable by Dcp1[+]/DCP1^b53

(Fan et al., 2011)

Ge-1^Δ5 has ventral denticle belt | germline clone phenotype, enhanceable by btz[+]/btz²

(Fan et al., 2011)

Ge-1^Δ5 has ventral denticle belt | germline clone phenotype, enhanceable by stau²/stau[+]

(Fan et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The posterior patterning defects of embryos derived from Ge-1^Δ5 female germline clones are not enhanced by Khc²⁷/+.

Dcp1^b53/+, btz²/+ and stau²/+ increase the penetrance of the posterior patterning phenotype of embryos derived from Ge-1^Δ5 female germline clones from 4% to 12.4%, 28.8% and 32.8% respectively.

(Fan et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Ge-1^Δ5 is rescued by Ge-1^{+tCH322-120M19}

(Cao et al., 2016)

Ge-1^Δ5 is rescued by Ge-1^{Δ78.CH322-120M19}

(Cao et al., 2016)

Ge-1^Δ5 is rescued by Ge-1^tub.B

(Fan et al., 2011)

Comments

Ge-1^{+tCH322-120M19} and Ge-1^{Δ78.CH322-120M19} each rescue the lethality of Ge-1^Δ5 homozygotes.

(Cao et al., 2016)

The posterior patterning defects of embryos derived from Ge-1^Δ5 female germline clones are rescued by Ge-1^tub.B.

(Fan et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ge-1^Δ5

(Trovisco et al., 2016)

dGe-1^Δ5

(Cao et al., 2016, Fan et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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