FB2024_03 , released June 25, 2024
Allele: Dmel\Ge-1Δ78.CH322-120M19
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General Information
Symbol
Dmel\Ge-1Δ78.CH322-120M19
Species
D. melanogaster
Name
FlyBase ID
FBal0318705
Feature type
allele
Associated gene
Dmel\Ge-1
Associated Insertion(s)
Carried in Construct
M{CH322-120M19.Ge-1Δ78}
Key Links
Transgenic product class
inframe_deletion
(Cao et al., 2016)
polymorphic_sequence_variant
(Cao et al., 2016)
Mutagen
    Nature of the Allele
    Transgenic product class
    inframe_deletion
    (Cao et al., 2016)
    polymorphic_sequence_variant
    (Cao et al., 2016)
    Mutagen
    Progenitor genotype
    Carried in construct
    M{CH322-120M19.Ge-1Δ78}
    Cytology
    Description

    BAC clone CH322-120M19, which includes Ge-1. The naturally occurring polymorphism found in Ge-1EME (78bp indel in the fifth exon, which reduces the length of the serine-rich linker region by 26 amino acid residues) has been introduced into the Ge-1 coding region.

    (Cao et al., 2016)
    Allele components
    Component
    Use(s)
    Regulatory region(s)
    Ge-1
    Encoded product / tool
    Ge-1
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Flies carrying Ge-1Δ78.CH322-120M19 are highly resistant to to Sigma virus; when assayed 10-16 days after infection, only 1.6% of flies carrying Ge-1Δ78.CH322-120M19 show symptoms of infection compared to 69.6% of control flies carrying Ge-1+tCH322-120M19.

        (Cao et al., 2016)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescues

        Ge-1Δ78.CH322-120M19 rescues Ge-1Δ5

        (Cao et al., 2016)
        Comments

        Ge-1Δ78.CH322-120M19 rescues the lethality of Ge-1Δ5 homozygotes.

        (Cao et al., 2016)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Ge-1Δ78.CH322-120M19
        Name Synonyms
        Secondary FlyBase IDs
          References (1)