FB2024_03 , released June 25, 2024
Allele: Dmel\Caf1-55short
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General Information
Symbol
Dmel\Caf1-55short
Species
D. melanogaster
Name
FlyBase ID
FBal0265622
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Caf1short
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: Q80term.

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    C15226181T

    Amino acid change:

    Q80term | Caf1-55-PA; Q79term | Caf1-55-PB

    Reported amino acid change:

    Q80term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous larvae appear grossly normal but mature slowly and die as first or second instars.

    Homozygous clones induced using hs-FLP do not survive in adults. Homozygous clones in the eye which have been generated using the ey-FLP; FRT cell lethal system are very small, comprising only a small portion of the eye. The remaining eye is small, highly disorganised and almost completely devoid of bristles. Approximately 20% of flies containing ey-FLP induced clones have extra or missing appendages on the head, including the ocelli, antennae and maxillary palps.

    Homozygous clones in the third larval instar eye disc which have been generated using the ey-FLP; FRT cell lethal system are small, show extensive apoptosis and have an irregular arrangement of photoreceptor clusters.

    Homozygous clones have not been recovered in the adult thorax.

    Caf1short/Caf1med flies expressing Caf1Scer\UAS.cAa under the control of Scer\GAL4Ubi and raised at 18[o]C during the third larval instar stage have disorganised kidney-shaped eyes with abnormalities in the arrangement of rhabdomeres (including loss of small central rhabdomeres) and show homeotic transformation of the arista to leg-like structures that occasionally end in claws. These defects are not seen if the animals are raised at 25[o]C during the third larval instar stage.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhancer of
    Statement
    Reference
    Suppressor of
    Statement
    Reference

    Caf1-55short/Caf1[+] is a suppressor of visible phenotype of Scer\GAL4lz-gal4, sensUAS.cNa

    Caf1-55short/Caf1[+] is a suppressor of visible | dominant phenotype of Pc15

    Phenotype Manifest In
    Enhancer of
    Statement
    Reference
    Suppressor of
    Statement
    Reference

    Caf1-55short/Caf1[+] is a suppressor of eye phenotype of Scer\GAL4lz-gal4, sensUAS.cNa

    Caf1-55short/Caf1[+] is a suppressor of sex comb | ectopic phenotype of Pc15

    Caf1-55short/Caf1[+] is a suppressor of mesothoracic leg phenotype of Pc15

    Caf1-55short/Caf1[+] is a suppressor of metathoracic leg phenotype of Pc15

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The mutant eye phenotype caused by expression of sensScer\UAS.cNa under the control of Scer\GAL4lz-gal4 is dominantly suppressed by Caf1short.

    Only 12.3% of Pc15/Caf1short double heterozygous males have ectopic sex combs on either the second or third leg.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (4)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (4)