FB2024_03 , released June 25, 2024
Allele: Dmel\Caf1-55long
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General Information
Symbol
Dmel\Caf1-55long
Species
D. melanogaster
Name
FlyBase ID
FBal0265620
Feature type
allele
Associated gene
Dmel\Caf1-55
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: G375D.

    (Anderson et al., 2011)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:15,227,177..15,227,177 [+]
    Nucleotide change:

    G15227177A

    Amino acid change:

    G375D | Caf1-55-PA; G374D | Caf1-55-PB

    Reported amino acid change:

    G375D

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Anderson et al., 2011)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Many homozygous larvae survive to the third instar, but die shortly after forming a disorganised pupa.

        Homozygous clones survive well in the eye. Eyes composed mostly of homozygous clones are only slightly disorganised compared to wild type. Some interommatidial bristles are missing or occasionally occur at adjacent vertices.

        (Anderson et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        Caf1[+]/Caf1-55long is a suppressor of visible phenotype of Scer\GAL4lz-gal4, sensUAS.cNa

        (Anderson et al., 2011)

        Caf1[+]/Caf1-55long is a suppressor of visible | dominant phenotype of Pc15

        (Anderson et al., 2011)
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        Caf1[+]/Caf1-55long is a suppressor of eye phenotype of Scer\GAL4lz-gal4, sensUAS.cNa

        (Anderson et al., 2011)

        Caf1[+]/Caf1-55long is a suppressor of sex comb | ectopic phenotype of Pc15

        (Anderson et al., 2011)

        Caf1[+]/Caf1-55long is a suppressor of mesothoracic leg phenotype of Pc15

        (Anderson et al., 2011)

        Caf1[+]/Caf1-55long is a suppressor of metathoracic leg phenotype of Pc15

        (Anderson et al., 2011)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The mutant eye phenotype caused by expression of sensScer\UAS.cNa under the control of Scer\GAL4lz-gal4 is dominantly suppressed by Caf1long.

        Only 30% of Pc13/Caf1long double heterozygous males have ectopic sex combs on either the second or third leg.

        (Anderson et al., 2011)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Caf1-55long
        Caf1long
        (Anderson et al., 2011)
        Caf1p55long
        (Collins and Moon, 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)