FB2024_03 , released June 25, 2024
Allele: Dmel\sggKK108994
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General Information
Symbol
Dmel\sggKK108994
Species
D. melanogaster
Name
FlyBase ID
FBal0235968
Feature type
allele
Associated gene
Dmel\sgg
Associated Insertion(s)
Carried in Construct
P{KK108994}
Also Known As
sgg RNAi, UAS-GSK3βRNAi, UAS-GSK3β RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK108994}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK108994
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurodegenerative disease
      modeled by Zzzz\CTG84.UAS.Tag:MYC,Tag:FLAG
      (van Eyk et al., 2011)
      ameliorates  tauopathy
      modeled by Hsap\MAPTUAS.cWa
      (Aqsa and Sarkar, 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of sggKK108994 under the control of Scer\GAL4Mef2.PR induces an increase in neurotransmission across the larval neuromuscular junction (muscle 6), as show by the significant decreases in the amplitude of excitatory junctional currents (eEJCs) and in the cumulative amplitude of miniature junctional currents (miniature junctional currents (mEJC)s), as compared to controls

      (Augustin et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Suppressed by
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of sggKK108994 with Zzzz\CTG84.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG under the control of Scer\GAL4GMR.PFa results in eyes of wild-type appearance.

      Co-expression of sggKK108994 with Zzzz\CAG93.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG under the control of Scer\GAL4GMR.PFa does not dramatically alter the exterior appearance of the eye compared with flies expressing Zzzz\CAG93.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG alone.

      Co-expression of sggKK108994 with Zzzz\CAGCAA.94.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG under the control of Scer\GAL4GMR.PFa does not dramatically alter the exterior appearance of the eye compared with flies expressing Zzzz\CAGCAA.94.Scer\UAS.T:Hsap\MYC,T:Zzzz\FLAG alone.

      (van Eyk et al., 2011)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sggKK108994
      Name Synonyms
      Secondary FlyBase IDs
        References (12)