FB2024_03 , released June 25, 2024
Allele: Dmel\MycJF01761
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General Information
Symbol
Dmel\MycJF01761
Species
D. melanogaster
Name
FlyBase ID
FBal0219810
Feature type
allele
Associated gene
Dmel\Myc
Associated Insertion(s)
Carried in Construct
P{TRiP.JF01761}
Also Known As
UAS-dmycRNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009.1.15)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009.1.15)
Mutagen
in vitro construct
(Perkins et al., 2009.1.15)
Progenitor genotype
Carried in construct
P{TRiP.JF01761}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.1.15)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF01761
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  cystic kidney disease
      modeled by BicC5
      (Gamberi et al., 2017)
      ameliorates  tauopathy
      modeled by Hsap\MAPTV337M.UAS
      (Pragati et al., 2020)
      ameliorates  frontotemporal dementia
      modeled by Hsap\MAPTV337M.UAS
      (Pragati et al., 2020)
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.cWa
      (Pragati and Sarkar, 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of MycJF01761 RNAi under the control of Scer\GAL4ap.PU does not increase levels of cell death (detected by Casp3 antibody staining) in third instar larval wing discs compared to controls.

      (Li et al., 2015)

      Expression of MycJF01761 in the fat body under the control of Scer\GAL4DcG results in significant hyperglycaemia.

      Expression of MycJF01761 in muscle under the control of Scer\GAL4Mef2.PU results in significant hyperglycaemia.

      (Ugrankar et al., 2015)

      Expression of MycJF01761 under the control of Scer\GAL4bs-1348 results in the truncation of terminal branches in the dorsal and lateral G branches of the larval trachea.

      (Wong et al., 2015)

      Larval fat body cell clones expressing dmJF01761 display fewer digesting autolysosomes than do wild-type cells.

      Fat body cell clones expressing dmJF01761 in well-fed larvae show cell-autonomous impairment of autophagy.

      (Nagy et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Enhancer of
      Suppressor of
      Other
      Phenotype Manifest In
      Enhanced by
      Enhancer of
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The Malpighian tubules deformities characteristic for BicC5 homozygous mutant adults are partially rescued by expression of MycJF01761 under the combined control of Scer\GAL4c42 and Scer\GAL4tsh-c724 drivers: the incidence of cysts is significantly reduced in the terminal and in the proximal tubule, the tubular swelling and the irregular distribution of cell nuclei is also reduced compared to controls.

      (Gamberi et al., 2017)

      The increased level of cell death (detected by Casp3 antibody staining) observed in wing discs of third instar larvae expressing REGKK102083 RNAi under the control of Scer\GAL4ap.PU is partially suppressed by co-expression of MycJF01761 RNAi.

      (Li et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      MycJF01761
      Myc[JF01761]
      (Nagy et al., 2015)
      Myc[i, JF01761]
      (Nagy et al., 2013)
      dmJF01761
      dmycJF01761
      (Pragati et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (18)