FB2024_03 , released June 25, 2024
Allele: Dmel\BicC5
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General Information
Symbol
Dmel\BicC5
Species
D. melanogaster
Name
FlyBase ID
FBal0001139
Feature type
allele
Associated gene
Dmel\BicC
Associated Insertion(s)
Carried in Construct
Also Known As
BicCYC33, Bic-CYC33
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  cystic kidney disease
      CEA
      (Millet-Boureima et al., 2019, Gamberi et al., 2017)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  cystic kidney disease
      is ameliorated by MycJF01762
      (Gamberi et al., 2017)
      is ameliorated by MycJF01761
      (Gamberi et al., 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      BicC5/Df(2L)RA5 adults show reduced survival rate (while BicC5/+ heterozygotes survive normally) and display deformations of their Malpighian tubules (disorganization of the tubular epithelial cells, large, often numerous cysts, extra branching) from an early age. These abnormal enlargements (cysts) are filled with fluid and contain dark crystalline particles. The cyst formation appears to increase over time and by day 30 the mutant flies display multiple cysts in both tubules and prominent deformities of the anterior terminal tubule. BicC5/Df(2L)RA5 mutants survive worse under high-salt diet stress conditions compared to wild-type, although they feed on it normally.

      Cysts are also observed in BicC5 homozygous adults and the tubules appear enlarged with irregular distribution of principal cell nuclei.

      (Gamberi et al., 2017)

      15% of embryos derived from heterozygous female hatch. Of the non-hatching embryos, 60% are bicaudal and 14% have head defects.

      (Castagnetti and Ephrussi, 2003)

      Phenotypically wild type embryos from heterozygous mothers localize vas protein normally throughout embryogenesis. In phenotypically bicaudal embryos the pole cells fail to coalesce into gonads.

      (Lasko and Ashburner, 1990)

      Strong BicC allele.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The Malpighian tubules deformities characteristic for BicC5 homozygous mutant adults are partially rescued by expression of either MycJF01762 or MycJF01761 (leads to weaker rescue) under the combined control of Scer\GAL4c42 and Scer\GAL4tsh-c724 drivers: the incidence of cysts is significantly reduced in the terminal and in the proximal tubule, the tubular swelling and the irregular distribution of cell nuclei is also reduced compared to controls.

      (Gamberi et al., 2017)

      72% of embryos derived from BicC5/aretQB females hatch. 65% of embryos derived from BicC5/+ ; orbmel/+ females hatch. Of the non-hatching embryos, 39% are bicaudal and 52% have head defects. 30% of embryos derived from BicC5/+ ; orbF303/+ females hatch. Of the non-hatching embryos, 62% are bicaudal and 30% have head defects. 87% of embryos derived from BicC5/+ ; orbF343/+ females hatch.

      (Castagnetti and Ephrussi, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      C. Nusslein-Volhard.

      (Roote, 1995.5.4)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (16)