FB2024_03 , released June 25, 2024
Allele: Dmel\TnpoGD33
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General Information
Symbol
Dmel\TnpoGD33
Species
D. melanogaster
Name
FlyBase ID
FBal0208848
Feature type
allele
Associated gene
Dmel\Tnpo
Associated Insertion(s)
Carried in Construct
P{GD33}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD33}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD33
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of TrnGD33 driven by Scer\GAL4GMR.PF results in occasional ommatidial fusion in the dorsal-anterior region of the adult eye.

      (Jäckel et al., 2015)

      Expression via "HHLT-gal4" or Scer\GAL4Hml.Δ or Scer\GAL4dome-PG14 results in loss of progenitor cells in the primary lobes of the larval lymph gland. ("HHLT-gal4" is a combination of Scer\GAL4HCH.Hand and Scer\GAL4Hml.Δ that express in early lymph gland blood cells (hemocytes) and circulating and sessile blood cells, respectively, and incorporates Scer\GAL4Scer\FRT.Rnor\CD2.Act5C to maintain expression in the lymph gland after Scer\GAL4HCH.Hand is down-regulated.)

      (Mondal et al., 2014)

      Expression under the control of Scer\GAL41407 results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.

      Expression under the control of Scer\GAL41407 may result in mild defects in the shape of ganglion mother cells in the larval brain (depending on the insertion line used).

      Expression under the control of Scer\GAL41407 may result in mild defects in the shape of neuroblasts in the larval brain (depending on the insertion line used).

      (Neumüller et al., 2011)

      Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in early pupal lethality or late pupal lethality.

      (Schnorrer et al., 2010)

      Expression under the control of Scer\GAL4pnr-MD237 results in lethality or semi-lethality at the pupal stage, depending on the insertion line used.

      Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 90-100% of the Scer\GAL4pnr-MD237-expressing area of the notum.

      (Mummery-Widmer et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of TrnGD33 enhances the severe eye defects resulting from expression of either Hsap\FUSScer\UAS.cJa.T:Ivir\HA1 or Hsap\FUSP525L.Scer\UAS.cJa.T:Ivir\HA1 driven by Scer\GAL4GMR.PF, as evident from the appearance of black lesions; it also enhances the modest eye defects resulting from the expression of Hsap\FUSR495X.Scer\UAS.T:Ivir\HA1 driven by Scer\GAL4GMR.PF.

      The co-expression of Hsap\TNPO1Scer\UAS.cJa strongly ameliorates the severe eye defects resulting from the combined expression of Hsap\FUSScer\UAS.cJa.T:Ivir\HA1 and TrnGD33, driven by Scer\GAL4GMR.PF, as compared to the expression of a control UAS-regulated transgene.

      (Jäckel et al., 2015)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 2 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Neuroblasts Screen Database (Knoblich Lab) - A database for RNAi phenotypes in larval neural stem cells
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TnpoGD33
      TrnGD33
      Name Synonyms
      Secondary FlyBase IDs
        References (12)