FlyBase Allele Report: Dmel\Snr1[GD4140]

FB2024_03 , released June 25, 2024

FB2024_03 , released June 25, 2024

Allele: Dmel\Snr1^GD4140

General Information

Symbol

Dmel\Snr1^GD4140

Species

D. melanogaster

Name

FlyBase ID

FBal0208565

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

Transgenic product class

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of rhabdoid cancer

CEA with BacA\p35^UAS.cHa

(Xie et al., 2017)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

lethal, with Scer\GAL4^Act5C.PI

(Dietz et al., 2015)

lethal, with Scer\GAL4^en.PU

(Dietz et al., 2015)

lethal, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

partially lethal - majority die, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

some die during pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^MD-638

(Terriente-Félix and de Celis, 2009)

visible, with Scer\GAL4^salm-459.2

(Terriente-Félix and de Celis, 2009)

visible | adult stage, with Scer\GAL4^en.PU

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PH

(Dietz et al., 2015)

posterior crossvein, with Scer\GAL4^en.PU

(Dietz et al., 2015)

wing, with Scer\GAL4^en.PU

(Dietz et al., 2015)

wing blade, with Scer\GAL4^en.PU

(Dietz et al., 2015)

wing blade, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

wing hair | ectopic, with Scer\GAL4^MD-638

(Terriente-Félix and de Celis, 2009)

wing hair | ectopic, with Scer\GAL4^salm-459.2

(Terriente-Félix and de Celis, 2009)

wing margin, with Scer\GAL4^MD-638

(Terriente-Félix and de Celis, 2009)

wing margin, with Scer\GAL4^salm-459.2

(Terriente-Félix and de Celis, 2009)

wing sensillum | ectopic, with Scer\GAL4^MD-638

(Terriente-Félix and de Celis, 2009)

wing sensillum | ectopic, with Scer\GAL4^salm-459.2

(Terriente-Félix and de Celis, 2009)

wing vein, with Scer\GAL4^MD-638

(Terriente-Félix and de Celis, 2009)

wing vein, with Scer\GAL4^salm-459.2

(Terriente-Félix and de Celis, 2009)

Detailed Description

Statement

Reference

Expression of Snr1^GD4140 is larval lethal at 25[o]C when driven by Scer\GAL4^Act5C.PI and pupal lethal Scer\GAL4^nub.PK (leads to unfurled or blisters wings at 18[o]C), Scer\GAL4^en.PU (leads to ectopic venation at posterior crossvein at 18[o]C) or Scer\GAL4^ey.PH (with escapers showing small deformed eyes, a phenotype also displayed by the flies kept at 18[o]C). No overt adult phenotype is observed with the Scer\GAL4^GMR.PF driver.

(Dietz et al., 2015)

Adults expressing Snr1^GD4140 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Depending on the insertion line used, expression under the control of Scer\GAL4^Mef2.PR can result in viable flies or early pupal lethality.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 may result in lethality, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

Expression of Snr1^GD4140 in the wing under the control of Scer\GAL4^salm-459.2 or Scer\GAL4^MD-638 results in the loss of wing veins and wing margin, a reduction in wing size, and ectopic wing hair and sensory organs.

(Terriente-Félix and de Celis, 2009)

External Data

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

4140

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^en.PU, Snr1^GD4140 has visible | adult stage phenotype, enhanceable by Scer\GAL4^en.PU/htt^GD14943

(Dietz et al., 2015)

Other

Statement

Reference

BacA\p35^UAS.cHa, Scer\GAL4^ptc.PU, Snr1^GD4140 has neoplasia | third instar larval stage phenotype

(Xie et al., 2017)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^en.PU, Snr1^GD4140 has wing phenotype, enhanceable by Scer\GAL4^en.PU/htt^GD14943

(Dietz et al., 2015)

Other

Statement

Reference

BacA\p35^UAS.cHa, Scer\GAL4^Act.PU, Snr1^GD4140 has wing disc | somatic clone | third instar larval stage phenotype

(Xie et al., 2017)

BacA\p35^UAS.cHa, Scer\GAL4^ptc.PU, Snr1^GD4140 has wing disc | third instar larval stage phenotype

(Xie et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The adult wing phenotype induced by expression of Snr1^GD4140 under the control of Scer\GAL4^en.PU at 18[o]C is enhanced by co-expression of htt^GD14943.

(Dietz et al., 2015)

Xenogenetic Interactions

Statement

Reference

Co-expression of Snr1^GD4140 and BacA\p35^Scer\UAS.cHa driven by Scer\GAL4^Act.PU in somatic (flip-out) clones or controlled by Scer\GAL4^ptc.PU in the wing disc of third instar larvae leads to increased cell proliferation and massive tissue overgrowth.

(Xie et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

v12645

w¹¹¹⁸; P{GD4140}v12645/TM3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

4140

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Snr1^GD4140

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections