Cul-5^EY21463/Df(3R)3450 larvae show a significant increase in bouton number and branching (counted from muscles 6 and 7 of abdominal segment A2), compared to controls.

Egg chambers from Cul-5^EY21463 females show defects including: absent nurse cells, degraded nurse cells.

Homozygous Cul-5^EY21463 mothers produce mostly collapsed eggs. Some of these mutant embryos develop aberrantly. Those that are morphologically normal show a reduction in the number of primordial germ cells compared with wild-type.

34% of Cul-5^EY21463 ovarioles in 1-2 day old flies contain at least one follicle with more than the normal 16 germ cells.

Many of the Cul-5^EY21463 ovarioles that contain a tumorous follicle also exhibit additional phenotypes, including egg chambers with fewer than 16 germ cells, egg chambers with a layer of somatic cells extending through the germ cell area, and germaria that are devoid of germ cells. The majority of the germ cells observed in Cul-5^EY21463 follicles have large, polyploid nuclei.

The tumorous follicle phenotype seen in Cul-5^EY21463 homozygotes does not become significantly more penetrant with age. However in 10 day old flies some egg chambers constitute a disorganised array of germ cells of differing sizes intermingled with somatic cells. The nuclear morphology of the cells in these follicles is not pycnotic.

A small proportion of the tumorous follicles seen in Cul-5^EY21463 mutants contain 2-3 randomly located oocytes, rather than the one posteriorly located oocyte that is seen in wild type. The disorganised egg chambers seen in 10 day old mutants also contain additional oocytes compared to controls. The majority of Cul-5^EY21463 egg chambers that have fewer than 16 cells contain a single oocyte.

Some Cul-5^EY21463 germaria contain large clusters of synchronously dividing germ cells that are not seen in controls. As in wild type no germ cell division occurs distal to the germarium.

Cul-5^EY21463 tumorous follicles frequently contain more than the 4 ring canals that are found in wild type and fusomes that span more than the usual 16 germ cells.

The number of germ cells seen in a tumorous Cul-5^EY21463 follicle is often not divisible by 16, indicating that the extra cells are not derived solely from an extra mitotic division.

The posterior germarium in Cul-5^EY21463 mutant flies often contains disorganised aggregates of germ cells rather than the organised groups of 16 cells that are observed in wild type flies.

Tumorous follicles in Cul-5^EY21463 mutants contain an extra set of differentiated polar cells compared to wild type.

Follicles containing more than 16 germ cells are present in the ovarioles of 1-2 day old Cul-5^EY21463/Cul-5^EY00051 flies.

Homozygous Cul-5^EY21463 mutants develop normally and do not display any overt morphological defects.

Cul5^EY21463, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

Cul5^EY21463 is a non-enhancer of abnormal neuroanatomy phenotype of Cul2^EY09124

Cul5^EY21463 has NMJ bouton | larval stage | increased number phenotype, non-enhanceable by Cul2^EY09124

Cul5^EY21463 has egg chamber phenotype, non-enhanceable by Cul2^EY09124

Cul5^EY21463, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

Cul5^EY21463 is a non-enhancer of NMJ bouton | larval stage | increased number phenotype of Cul2^EY09124

Cul5^EY21463 is a non-enhancer of egg chamber phenotype of Cul2^EY09124